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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Trucking industry demand for urban shared use freight terminals显示文摘 | Amelia C Regan Thomas F Golob | 2005 | Transportation2005，32，： | 1 |
| 3 | Novel Approaches for Preventing or Limiting Events (Naples) II Trial : Impact of a Single High Loading Dose of Atorvastatin on Periprocedural Myocardial Infarction 显示文摘 | Carlo B Gahriella V Amelia F | 2009 | J AmColl Cardiol2009，54，23： | 1 |
| 4 | Mir-15 and mir-16 induce apoptosis by targeting Bcl-2 显示文摘 | AMELIA C GEORGE A C MULLER F | 2005 | Proc Natl Acad Sci USA2005，102，13： | 1 |
| 5 | Impact of asingle High Loading Dosa of Atorvastatin on Periprocedural Myocardial Infarction显示文摘 | Carlo B Gabriella V Amelia F | 2009 | J Am Col Cardio2009，54，23： | 1 |
| 6 | Impacts of Infor- mation Technology on Personal Travel and Commercial Vehicle Operations: Research Challenges and Opportunities显示文摘 | Thomas F G Amelia C R | 2001 | Transporta- tion Research Part C2001，9，2： | 1 |
| 7 | miR-15 and miR-16 induce apoptosis by targeting BCL2 显示文摘 | Amelia C George AC Muller F | 2005 | Proc Natl Acad Sci2005，102，13： | 1 |
| 8 | The perceived usefulness of different sources of traffic information to trucking operations 显示文摘 | THOMAS F G AMELIA C R | 2002 | Transportation Research Part E2002，38，2： | 1 |
| 9 | Impact of a single high loading-dosa of atorvastatin on periprocedural myocardial infarction显示文摘 | Carlo B Gabriella V Amelia F | | 0，，23： | 1 |
| 10 | Neonatal Hear-ing Screening : Failures, hearing loss and risk indicators显示文摘 | Raquel M O Marisa F A Amelia M N | 2011 | Braz J Otorhinolaryngol2011，，6： | 1 |
| 11 | Trucking industry adoption of information technology: A multivariate discrete choice model显示文摘 | Thomas F Golob A Amelia C | 2002 | Transportation Research Part C2002，10，： | 1 |
| 12 | Impact of a single high loading dosa of atorvastatin on periprocedural myocardia| In- farction显示文摘 | CARLO B GABRIELLA V AMELIA F | 2009 | J Am Coil Cardiol2009，54，23： | 1 |
| 13 | Impact of a single High Load- ing Dosa of Atorvastatin on Periprocedural Myocardial Infarction 显示文摘 | Carlo B Gabriella V Amelia F | 2009 | J Am Coll Cardiol2009，54，23： | 1 |
| 14 | MR imaging of at- lantoaxial joint in early rheumatoid arthritis 显示文摘 | Magarelli N Simone F Amelia R | 2010 | Radioi Med2010，115，： | 1 |
| 15 | Regan Tragic congestion and trucking managers' use of automated routing and scheduling 显示文摘 | Thomas F Golob Amelia C | 2003 | Transportation Research PartE2003，39，： | 1 |
| 16 | Detection of testostereone and estrogen receptors in the post-menopausal endometrium 显示文摘 | Maia H Jr Amelia M Paulo F | 2001 | Maturitas2001，38，5： | 1 |
| 17 | Impacts of highway congestion on freight operations: perceptions of trucking industry managers 显示文摘 | Thomas F G Amelia C R | 2001 | Transportation Research Part A:Policy and Pracfice2001，35，7： | 1 |
| 18 | miR-15 and miR-16 induce apoptosis by targeting BCL2显示文摘 | Amelia C George AC Muller F | 2005 | PNAS2005，102，13： | 1 |
| 19 | Impacts of information technology on personal travel and commercial vehicle operations:research challenges and opportunities显示文摘 | Thomas F Golob Amelia C Regan | 2011 | Implications of New Information Technology2011，4，9： | 1 |
| 20 | Lactic acid bacterial diversity in the traditional Mexican fermented dough pozol as determined by 16S rDNA sequence analysis 显示文摘 | ADELFO E CARMEN W AMELIA F | 2001 | Int J Food Microbiol2001，64，： | 1 |
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