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| 1 | Screening for Gastric Cancer and Surveillance of Premalignant Lesions: a Systematic Review of Cost‐Effectiveness Studies显示文摘 | Miguel Areia Rita Carvalho Ana Teresa Cadime Francisco Rocha Gon?alves Mário Dinis‐Ribeiro | 2013 | Helicobacter2013，，5： | 3 |
| 2 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 3 | Organic speciation of aerosols from wildfires in central Portugal during summer 2009显示文摘 | Ana Vicente Célia Alves Cristina Monteiro Teresa Nunes Fátima Mirante Mário Cerqueira Ana Calvo Casimiro Pio | 2012 | Atmospheric Environment2012，，： | 1 |
| 4 | Measurement of trace gases and organic compounds in the smoke plume from a wildfire in Penedono (central Portugal)显示文摘 | Ana Vicente Célia Alves Cristina Monteiro Teresa Nunes Fátima Mirante Margarita Evtyugina Mário Cerqueira Casimiro Pio | 2011 | Atmospheric Environment2011，，29： | 1 |
| 5 | Three Dimensional Computerized Orthographic Surgical Treatment Planning 显示文摘 | Pa~cia VM Alves Ana M Bolognese | 2006 | Clinics in Plastic Surgery (S0889-5406)2006，130，6： | 1 |
| 6 | In vivo growth inhibition of sarcoma 180 by latex proteins from Calotropis procera显示文摘 | Jefferson S. Oliveira Letícia V. Costa-Lotufo Daniel P. Bezerra Nylane M. N. Alencar José Delano B. Marinho-Filho Ingrid Samantha T. Figueiredo Manoel O. Moraes Claudia Pessoa Ana Paula N. N. Alves Márcio V. Ramos | 2010 | Naunyn - Schmiedeberg’s Archives of Pharmacology2010，，2： | 1 |
| 7 | Autoimmune gastritis presenting as iron deficiency anemia in childhood显示文摘AIM: To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting of unexplained iron deficiency anemia investigation.METHODS: A descriptive, observational study including pediatric patients with a diagnosis of autoimmune gastritis(positive parietal cell antibody and gastric corpus atrophy) established in a 6 year period(2006-2011) in the setting of refractory iron deficiency anemia(refractoriness to oral iron therapy for at least 6 mo and requirement for intravenous iron therapy) investigation, after exclusion of other potentially contributing causes of anemia. Helicobacter pylori(H. pylori) infection and anti-secretory therapy were also excluded. Data were retrospectively collected from clinical files, including: demographic data(age, gender, and ethnic background), past medical history, gastrointestinal symptoms, familial history, laboratorial evaluation(Hb, serum ferritin, serum gastrin, pepsinogen Ⅰ/ pepsinogen Ⅱ, B12 vitamin, intrinsic factor autoantibodies, thyroid autoantibodies, and anti-transglutaminase antibodies), and endoscopic and histological findings(HE, Periodic Acid-Schiff/Alcian blue, gastrin, chromogranin A and immunochemistry analysis for CD3, CD20 and CD68). Descriptive statistical analysis was performed(mean, median, and standard deviation).RESULTS: We report a case-series concerning 3 girls and 2 boys with a mean age of 13.6 ± 2.8 years(3 Caucasian and 2 African). One girl had type Ⅰ diabetes. Familial history was positive in 4/5 cases, respectively for autoimmune thyroiditis(2/5), sarcoidosis(1/5) and multiple myeloma(1/5). Laboratorial evaluation on admission included: Hb: 9.5 ± 0.7 g/d L; serum ferritin: 4.0 ± 0.9 ng/m L; serum gastrin: 393 ± 286 pg/m L; low pepsinogen Ⅰ/ pepsinogen Ⅱ ratio in 1/5 patients; normal vitamin B12 levels(analyzed in 3 patients). Endoscopy findings included: duodenal nodularity(2/5) and gastric fold softening(2/5), and histological evaluation showed corpus atrophic gastritis with lymphocytic infiltration(5/5), patchy oxyntic gland mononuclear cell infiltration(5/5), intestinal and/or pseudo-pyloric metaplasia in corpus mucosa(4/5), and enterochromaffin cell hyperplasia(4/5). Immunochemistry for gastrin on corpus biopsies was negative in all cases. Duodenal histology was normal. All biopsies were negative for H. pylori(Giemsa staining and cultural examination). CONCLUSION: We highlight autoimmune gastritis as a diagnosis to be considered when investigating refractory iron deficiency anemia in children, particularly in the setting of a personal/familial history of autoimmune disease, as well as the diagnostic contribution of a careful immunohistological evaluation. | Cristina Gon?alves Maria Emília Oliveira Ana M Palha Anabela Ferr?o Anabela Morais Ana Isabel Lopes | 2014 | World Journal of Gastroenterology2014，20，42： | 1 |
| 8 | Treatment of a pesticide-containing wastewater using combined biological and solar-driven AOPs at pilot scale显示文摘 | Francisca C. Moreira Vítor J.P. Vilar Ana C.C. Ferreira Felipe R.A. dos Santos Márcia Dezotti M.A. Sousa C. Gon?alves Rui A.R. Boaventura M.F. Alpendurada | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 9 | Oral intake throughout the patients’ lives after palliative metallic stent placement for malignant gastroduodenal obstruction: a retrospective multicentre study显示文摘 | Jorge M. Canena Ana C. Lagos Inês N. Marques Sara D. Patrocínio Miguel G. Tomé Manuel A. Liberato Carlos M. Rom?o António P. Coutinho Pedro M. Veiga Beatriz C. Neves Hélder D. Além José A. Gon?alves | 2012 | European Journal of Gastroenterology & Hepatology2012，，7： | 1 |
| 10 | IL1B and IL1RN polymorphic genes and Helicobacter pylori cag A strains decrease the risk of reflux esophagitis显示文摘 | Dulciene Maria Magalh?es Queiroz Juliana Becattini Guerra Gifone Aguiar Rocha Andreia Maria Camargos Rocha Adriana Santos Adriana Gon?alves de Oliveira M?nica Maria Demas álvares Cabral Ana Margarida Miguel Ferreira Nogueira Celso Affonso de Oliveira | 2004 | Gastroenterology2004，，1： | 1 |
| 11 | Quantifying process equivalence based on ob- served behavior 显示文摘 | Ana Karla Alves de Medeiros Wil M P van der Aalst Wei- jters A J M M | 2008 | Data & Knowledge Engineering2008，64，1： | 1 |
| 12 | Hepatic adenomatosis in glycogen storage disease:Radio-pathological correlation显示文摘Glycogen storage disease type I(GSD type I),also known as von Gierke disease,is an autosomal recessive disorder of the glycogen metabolism pathway,caused by a deficiency of glucose-6-phosphatase(GSD type Ia)or glucose-6-phosphate translocase(GSD type Ib)[1]. | João M Louro Ana M Alves JoséR Brandão Manuela França | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，6： | 0 |
| 13 | Evolution of costs of cancer drugs in a Portuguese hospital显示文摘AIM:To analyze the costs of cancer drugs administered in a Portuguese Hospital compared with the Karolinska Institute study.METHODS:To evaluate spending on cancer drugs, we retrospectively analyzed data on the overall costs of cancer drugs, obtained at the Department of Medical Oncology of the Centro Hospitalar de Entre Douro e Vouga, between 2004 and 2010. In this comparative study we selected only drugs belonging to the following groups:chemotherapy, targeted therapy, immunotherapy and endocrine therapy. The selected drugs were further grouped according to their market placement year:≤ 1998, 1999 to 2002, 2003 to 2005, and 2006 to 2010. Drugs used as supportive therapy and bisphosphonates were excluded.RESULTS:The overall costs of cancer drugs increased gradually between 2004 and 2008(from €1911947 to €3666284), with an increase in the number of patients treated during this period. The expenditure decreased in 2009(€3438155) and increased again in 2010(€3673116), but the costs increment was not the same as in previous years. Chemotherapy and targeted therapy were responsible for most of the expenditure. Drugs placed on the national market before 1999 accounted for more than 50% of the expenditure up to 2007. From 2008, these drugs represented less than 50% of the total expenditure. Cancer drugs placed between 1999 and 2002 accounted for 25%-35% of the costs in all the years studied, while drugs placed between 2003 and 2005 accounted for less than 30%. Drugs placed between 2006 and 2010 were responsible for less than 10% of the expenditure.CONCLUSION:In this study, older drugs were responsible for most of the expenditure up to 2007, which is in agreement with the Karolinska study. | Vania Peixoto Ana Luísa Faria Márcia Gon?alves Joana Macedo Sónia Rego Emilio Macías Aldiro Magano Márcia Loureiro António Araújo | 2014 | World Journal of Clinical Oncology2014，5，2： | 0 |
| 14 | In vitro performance and in vivo fertility of antibiotic-free preserved boar semen stored at 5℃显示文摘Background: Hypothermic preservation of boar semen is considered a potential method for omitting antibiotics from insemination doses, thereby contributing to the global antibiotic resistance defence strategy. The main challenges are chilling injury to spermatozoa and bacterial growth during semen storage leading to reduced fertility.Objectives: To examine chilling injury and the number and type of bacteria in boar semen stored at 5 ℃ in the absence of antibiotics, and to assess the applicability of hypothermic semen storage under field conditions.Material and methods: Boar ejaculates were extended with AndroStar~? Premium, stored at 17 ℃ with and at 5 ℃ without antibiotics and tested for functional sperm parameters by flow cytometry. Raw semen and extended samples were investigated bacteriologically. Fertility was evaluated after once-daily inseminations of 194 sows in a field study.Results: Lethal sperm damage assessed by motility and membrane integrity was low throughout storage in both experimental groups. Sublethal chilling effects based on the decrease of viable spermatozoa with low membrane fluidity were higher(P < 0.05) up until 72 h in sperm stored at 5 ℃ compared to 17 ℃ but did not differ after 144 h.After 72 h, incubation in capacitating medium for 60 min induced a similar decrease in viable sperm with high mitochondria membrane potential and low cytosolic calcium in both groups. In semen stored at 5 ℃, bacteria counts were below 103 CFU/mL and the bacteria spectrum was similar to that of raw semen. In 88% of 34 boars,cooled semen fulfilled the requirements for insemination. Fertility was high and did not differ(P > 0.05) between sow groups inseminated with semen stored antibiotic-free at 5 ℃ and semen stored at 17 ℃ with antibiotics.Conclusion: Despite subtle chilling effects and low bacterial numbers, antibiotic-free hypothermic storage of boar semen offers the possibility to reduce the use of antibiotics in pig insemination. However, strict sanitary guidelines must be maintained and further evidence of efficiency under field conditions is considered desirable. | Helen Jäkel Kathi Scheinpflug Kristin Mühldorfer Rafael Gianluppi Matheus Schardong Lucca Ana Paula Gonçalves Mellagi Fernando Pandolfo Bortolozzo Dagmar Waberski | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 0 |
| 15 | Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity显示文摘T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of antigens.Glycosylation is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/functions.Although these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to disease.Here,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic alterations.After restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1CreMgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and infection.We further demonstrated that a single N-glycan antenna(modeled in Rag1CreMgat2fl/fl mice)is the sine-qua-non condition to ensure normal development.In conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility. | Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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