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13篇 您的检索式：作者名="Ana MP"

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		题名	作者	年代	出处	被引量
	1	hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis.	Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos	2016	World Journal of Gastroenterology2016，22，6：	7
	2	Preoperative chemotherapy for colorectal liver metasases:impact on hepatic histology and postoperative outcome显示文摘	Timothy MP Kelly O Ana LG	2007	Gastrointest Surg2007，11，7：	1
	3	Bovine whey proteins-overview on their main biological properties显示文摘	Ana R Madureira Cláudia I Pereira Ana MP Gomes	2007	Food Research International2007，40，10：	1
	4	Perinatal results following the prenatal ultrasound diagnosis of single umbilical artery显示文摘	Cristina MP Ana G Ines T	2005	Acta Obstet Gyneeol seand2005，84，11：	1
	5	Microstructural and drug release properties of oven - dried and of slowly or fast frozen freeze - dried MCC - Carbopol pellets显示文摘	Ana GC Consuelo S Ramon MP	2007	European Journal of Pharmaceutics and Biopharma- ceutics2007，67，1：	1
	6	The Pediatric Quality of Life InventoryTM (PedsQLTM) family impact module reliability and validity of the Brazilian version显示文摘	Ana CS Saul MP Isabela AP	2008	Health and Quality of Life Outcomes2008，6，：	1
	7	Perinatal results following the prenatal ultrsound diagnosis of single umbillcal artery显示文摘	Cristina MP Ana G Inés T		0，，11：	1
	8	Preoperative chemotherapy for colorectal liver metasases: impact on hepatic histology and postoperative outcome 显示文摘	Timothy MP Kelly O Ana LG	2007	J Gastrointest Surg2007，11，7：	1
	9	Application of chitosan emulsion as a coating on kraft paper显示文摘	Reis Arlete B Yoshida Cristiana Mp Reis Ana Paula C	2011	Polymer International2011，60，6：	1
	10	The noni fruit:A review of agricultural research nutritional and therapeutic properties显示文摘	Yanine CB Fabrice V Ana MP	2006	J Food Compost Anal2006，19，7：	1
	11	Perinatal results following the prenatal ultrasound diagnosis of single umbilical artery显示文摘	Cristina MP Ana G Ines T	2005	Acta Obstet Gynecol Scand2005，84，11：	1
	12	Perinatal results following the prenatal ultrasound diagnosis of single umbilical artery显示文摘	Cristina MP Ana G Ines T	2005	Acta Obstet Gynecol Scand2005，84，：	1
	13	Perinatal results following the prenatal ultrasound diagnosis of single umbilical artery显示文摘	Cristina MP Ana G In6s T	2005	Acta Obstet Gynecol Scand2005，84，11：	1

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