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| 1 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 2 | Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases:A review显示文摘Inflammatory bowel diseases(IBD)include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated.The intestinal microbiome has been studied as a causal component,with certain microbiotic alterations having been observed in subtypes of IBD.Physical exercise is a modulator of the intestinal microbiome,causing shifts in its composition that are partially corrective of those observed in IBD;furthermore,physical exercise may be beneficial in patients with certain IBD subtypes.This review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity’s clinical effects on patients with IBD. | Tilemachos Koutouratsas Anastassios Philippou George Kolios Michael Koutsilieris Maria Gazouli | 2021 | World Journal of Gastroenterology2021，27，30： | 4 |
| 3 | Vitamin D and diabetes显示文摘 | Anastassios G. Pittas Bess Dawson-Hughes | 2010 | Journal of Steroid Biochemistry and Molecular Biology2010，，1： | 3 |
| 4 | Association between Serum Osteocalcin and Markers of Metabolic Phenotype显示文摘 | Anastassios G. Pittas Susan S. Harris Myrto Eliades Paul Stark Bess Dawson-Hughes | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，3： | 1 |
| 5 | The role of nerve growth factor in the prophylaxis and treatment of dia- betic foot ulcers 显示文摘 | Elisavet K Tiaka Nikolaos Papanas Anastassios C Manolakis | 2011 | Int J Bum Trauma2011，，1： | 1 |
| 6 | Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site显示文摘 | Anastassios C Papageorgiou1 K Ravi Acharyal Robert Shapiro | | 0，，： | 1 |
| 7 | α2-Heremans-schmid glycoprotein(fetuin A)downregulation and its utility in inflammatory bowel disease显示文摘AIM To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein(AHSG/fetuin A) and potential associations with disease and patient characteristics.METHODS AHSG serum levels were determined in treatment-na?ve newly-diagnosed patients, 96 with ulcerative colitis(UC), 84 with Crohn's disease (CD), 62 with diarrheapredominant or mixed irritable bowel syndrome (IBS, D- and M- types) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA).All patients were followed for a minimum period of 3 years at the Gastroenterology Department of the University Hospital of Larissa, Greece. C-reactive protein(CRP), anti-glycan antibodies, anti-Saccharomyces cerevisiae mannan antibodies Ig G, anti-mannobioside carbohydrate antibodies Ig G, anti-laminariobioside carbohydrate antibodies Ig G and anti-chitobioside carbohydrate antibodies Ig A were also determined via immunonephelometry and ELISA, respectively.RESULTS The mean ± SE of serum AHSG, following adjustment for confounders, was 0.32 ± 0.02 g/L in IBD, 0.32 ± 0.03 g/L in CD and 0.34 ± 0.03 g/L in UC patients, significantly lower than in IBS patients(0.7 ± 0.018 g/L) and HC (0.71 ± 0.02 g/L) (P < 0.0001, in all cases). AHSG levels were comparable between the CD and UC groups. Based on AHSG levels IBD patients could be distinguished from HC with about 90% sensitivity and specificity. Further adjusted analysis verified the inverse association between AHSG and penetrating, as well as stricturing CD (partial correlation coefficient: -0.45 and -0.33, respectively) (P < 0.05). After adjusting for confounding factors, inverse correlations between AHSG and CRP and the need for anti-TNFα therapy or surgery, were found (partial correlation coefficients:-0.31,-0.33,-0.41, respectively, P < 0.05, in all cases). Finally, IBD individuals who were seropositive, for at least one marker, had AHSG levels falling within the two lower quartiles (OR = 2.86, 95%CI: 1.5-5.44, P < 0.001) while those with at least two serological markers positive exhibited AHSG concentrations within the lowest quartile (OR = 5.03, 95%CI: 2.07-12.21, P < 0.001), after adjusting for age, sex and smoking.CONCLUSION AHSG can be used to distinguish between IBD and IBS patients or HC while at the same time 'predicting' complicated disease behavior, need for therapy escalation and surgery. Moreover, AHSG may offer new insights into the pathogenesis of IBD, since it is involved in key processes. | Anastassios C Manolakis Gregory Christodoulidis Andreas N Kapsoritakis Panagiotis Georgoulias Elisavet K Tiaka Kostas Oikonomou Varvara J Spyros P Potamianos | 2017 | World Journal of Gastroenterology2017，23，3： | 1 |
| 8 | The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis显示文摘 | Anastassios G. Pittas Joseph Lau Frank B. Hu Bess Dawson-Hughes | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，6： | 1 |
| 9 | Readressing the Role of Toll - Like Receptor - 4 Alleles in Inflammatory Bowel Disease: Colitis, Smoking, and Seroreactivity显示文摘 | Anastassios C. Manolakis Andreas N. Kapsoritakis Anastasia Kapsoritaki Elisavet K. Tiaka Konstantinos A. Oikonomou Vassilis Lotis Dimitra Vamvakopoulou Ioanna Davidi Nikolaos Vamvakopoulos Spyros P. Potamianos | 2013 | Digestive Diseases and Sciences2013，，2： | 1 |
| 10 | The development impact of solar cookers: A review of solar cooking impact research in South Africa 显示文摘 | Wentzela Marlett Pouris Anastassios | 2007 | Energy Policy2007，35，3： | 1 |
| 11 | Vitamin D and diabetes显示文摘 | Joanna M Anastassios G P | 2014 | Endocrinol J Metab ClinNorth Am2014，43，1： | 1 |
| 12 | Effects of a 70% biodie-sel blend on the fuel injection system operation duringsteady-state and transient performance of a commonrail diesel engine显示文摘 | Dimitrios T Anastassios S | 2012 | Energy Conversion and Man-agement ?2012，60，： | 1 |
| 13 | MicroRNAs Control Intestinal Epithelial Differentiation, Architecture, and Barrier Function显示文摘 | Lindsay B. McKenna Jonathan Schug Anastassios Vourekas Jaime B. McKenna Nuria C. Bramswig Joshua R. Friedman Klaus H. Kaestner | 2010 | Gastroenterology2010，，5： | 1 |
| 14 | The development impact of solar cookers:Areview of solar cooking impact research in South Africa显示文摘 | Marlett Wentzel Anastassios Pouris | 2007 | Energy Policy2007，35，3： | 1 |
| 15 | Positive Emotions as Generators of Therapeutic Change显示文摘 | Fitzpatrick Marilyn R Stalikas Anastassios | 2008 | Journal of Psychotherapy Integration2008，18，2： | 1 |
| 16 | Meningioangiomatosis with predominantly cellular pattern显示文摘 | Anastassios VKoutsopoulos AndreasYannopoulos Efstathios NStathopoulos AthanasiosEvangeliou John GPanayiotides MariaKafousi AntonisKrasoudakis EvagelosMarkakis George SDelides | 2003 | Neuropathology2003，，2： | 1 |
| 17 | Effect of climatic conditions on the design optimization of heat pump systems for space heating and cooling显示文摘 | OLYMPIA ZOGOU ANASTASSIOS STAMATELOS | 1998 | Energy Convers1998，39，7： | 1 |
| 18 | Effects of a 70% biodiesel blend on the fuel injection system operation during steady-state and transient performance of a common rail diesel engine显示文摘 | DIMITRIOS T ANASTASSIOS S | 2012 | Energy Conversion and Manage2012，60，4： | 1 |
| 19 | Vitamin D and diabetes显示文摘 | Joanna M Anastassios GP | 2014 | Endocrinol Metab Clin North Am2014，43，1： | 1 |
| 20 | Following the leader: bacterial protein export through the Sec pathway显示文摘 | Anastassios Economou | 1999 | Trends in Microbiology1999，，8： | 1 |
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