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| 1 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 2 | Portal vein thrombosis in cirrhotic patients-it is always the small pieces that make the big picture显示文摘Portal vein thrombosis(PVT) is a frequent and serious complication in patients with liver cirrhosis(LC). Recently, a new classification of PVT was proposed, although the functional component was not completed included. The status of liver disease(compensated/decompensated) should be added to this classification. Reduced portal flow velocity and the acquired hypercoagulable status associated with LC are the main risk factors for PVT development, although endothelial dysfunction may play an important role that needs to be further evaluated. The European Association for the Study of the Liver and the American Association for the Study of Liver Disease recommend that the anticoagulant treatment should be consider in cirrhotic patients with PVT. Low molecular weight heparin and vitamin K antagonists proved their efficacy and relatively safety in PVT treatment, although in addition to recanalization rates, more complex endpoints such as mortality and decompensation rate should be evaluated. The new oral anticoagulant therapies offers the advantage of oral administration in the absence of laboratory monitoring, however, there are a few reports regarding their use in cirrhotic patients, most of them referring to compensated isolated cases. Transjugular intrahepatic portosystemic shunt could be an alternative if thrombosis progresses despite anticoagulatant therapy and/or when PVT is associated with portal hypertension complications. The aim of this editorial is to discuss the different aspects of pathophysiology, clinical relevance, diagnosis and management of PVT in patients with LC. | Irina Girleanu Anca Trifan Carol Stanciu Cǎtǎlin Sfarti | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 3 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 4 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 5 | Biodistribution of phosphodiester and phosphorothioate siRNA 显示文摘 | BRAASCH DA ZAIN P ANCA C | 2004 | Bioorg Med Chem Lett2004，14，12： | 1 |
| 6 | Image cytometry:an aid for cytological diagnosis of pleural effusions显示文摘 | Osterheld MC Liette C Anca M | 2005 | Diagn Cytopathol2005，，3： | 1 |
| 7 | A peroxidase gene promoter induced by phytopathogens and Methyl Jasmonate in transgenic plant显示文摘 | Mark D C Anne L R Anca G R | 1997 | Molecular Plant-Microbe Interactions1997，10，： | 1 |
| 8 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 9 | Image cytometry:an aid for cytological diagnosis of pleural effusions显示文摘 | Osterheld MC Liette C Anca M | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 10 | Image cytometry:an aid for cyto-logical diagnosis of pleural effusions显示文摘 | Osterheld MC Liette C Anca M | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 11 | hnage cytometry : an aid for cytolngical diagnosis of pleural effusions 显示文摘 | Osterheld M C Liette C Anca M | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 12 | Image cytometry:an aid for cytological diagnosis of pleural effusions显示文摘 | Osterheld MC Liette C Anca M | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 13 | Image eytometry: an aid for cytological diagnosis of pleural effusions 显示文摘 | Osterheld MC Liette C Anca M | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 14 | MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment显示文摘 | Dorhoi Anca Iannaccone Marco Farinacci Maura Fa? Kellen C Schreiber J?rg Moura-Alves Pedro Nouailles Geraldine Mollenkopf Hans-Joachim Oberbeck-M?ller Dagmar J?rg Sabine Heinemann Ellen Hahnke Karin L?we Delia Del Nonno Franca Goletti Delia | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 15 | AGEs and glucose levels modulate type Ⅰ and Ⅲ procollagen mRNA synthesis in dermal fibroblasts cells culture显示文摘 | Andreea SI Marieta C Anca D | 2008 | Exp Diabetes Res2008，2008，： | 1 |
| 16 | AGEs and glucoselevels modulate type I and III procollagen mRNA synthesis in dermalfibroblasts cells culture显示文摘 | ANDREEA S I MARIETA C ANCA D | 2008 | Experimental Diabetes Research2008，2008，： | 1 |
| 17 | Image cytometry: an aid for cytological diagnosis of pleural effusions 显示文摘 | OSTERHELD MC LIETTE C ANCA M | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 18 | Progress in the field of conducting polymers for tissue engineering applications显示文摘 | Anca D B Luminita C Ioan C | 2011 | J Biol Appl2011，26，7： | 1 |
| 19 | The role of chemo - radiotherapy in the management of locally advanced carcinoma of the vulva显示文摘 | Lisa T Anca C Ansink | 2011 | A- merican journal of clinical oncology2011，34，： | 1 |
| 20 | Weekly systemic cisplatin plus locoregional hyperthermia: An effective treatment for patients with recurrent cervical carcinoma in a previously irradiated area显示文摘 | Martine F Ronald DW Anca C | 2007 | Int J Hyperthermia2007，23，44： | 1 |
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