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| 1 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Expression of a novel high-molecular-weight glutenin subunit gene in transgenic wheat显示文摘 | Blechl A E Anderson O D | 1996 | Nat Biotechnol1996，14，： | 2 |
| 4 | Challenges in the diagnosis of intestinal neuronal dysplasia type B:A look beyond the number of ganglion cells显示文摘Intestinal neuronal dysplasia type B(IND-B)is a controversial condition among gastrointestinal neuromuscular disorders.Constipation is its most common clinical manifestation in patients.Despite intense scientific research,there are still knowledge gaps regarding the diagnostic criteria for IND-B in the histopathological analysis of rectal biopsies.The guidelines published in the past three decades have directed diagnostic criteria for quantifying the number of ganglion cells in the nervous plexus of the enteric nervous system.However,it is very complex to distinguish numerically what is pathological from what is normal,mainly because of the difficulty in determining a reliable control group composed of healthy children without intestinal symptoms.Thus,a series of immunohistochemical markers have been proposed to assist in the histopathological analysis of the enteric nervous system.Several of these markers facilitate the identification of other structures of the enteric nervous system,in addition to ganglion cells.These structures may be related to the etiopathogenesis of IND-B and represent new possibilities for the histopathological diagnosis of this disease,providing a view beyond the number of ganglion cells.This review critically discusses the aspects related to the disease definitions and diagnostic criteria of this organic cause of constipation. | Simone Antunes Terra Anderson Cesar Gonçalves Pedro Luiz Toledo de Arruda Lourenção Maria Aparecida Marchesan Rodrigues | 2021 | World Journal of Gastroenterology2021，27，44： | 2 |
| 5 | Bose-Einstein condensation in a gas of sodium atoms显示文摘 | DAVIES K B MEWES M O ANDERSON M R | 1995 | Phys Rev Lett1995，75，22： | 2 |
| 6 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 7 | Stress corrosion theory of crack propagation with applications to geophysics显示文摘 | ANDERSON O L | 1977 | Reviews of Geophysics and Space Physics1977，159，1： | 1 |
| 8 | The characterization and comparative analysis of high-molecular-weight glutenin genes from genomes A and B of a hexaploid bread wheat显示文摘 | Anderson O D Greene F C | 1989 | Theor Appl Genet1989，77，： | 1 |
| 9 | Anharmonicity and the equation of state for gold显示文摘 | Anderson O L Isaak D G Yamamoto S | 1989 | J Appl Phys1989，65，： | 1 |
| 10 | Rheumatoid arthritis:review of psychological factors related to etiology,effects,and treatment显示文摘 | Anderson K O Bradley L A Young L D | 1985 | Psychol Bull1985，98，2： | 1 |
| 11 | The dependence of the δT upon compression at extreme conditions显示文摘 | ANDERSON O L ISAAK D G | 1993 | Phys Chem Solids1993，54，： | 1 |
| 12 | Improved standing-wave-type sloshing absorber显示文摘 | Anderson J G Semereigil S E Turan O F | 2000 | Journal of Sound and Vibration2000，235，4： | 1 |
| 13 | Flow of a heated ferrofluid over a stretching sheet in the presence of a magnetic dipole 显示文摘 | Anderson H I Valnes O A | 1998 | Acta Mechanica1998，128，12： | 1 |
| 14 | Character- ization,dynamics, and ecological impacts of harmful Cochlodini- um polykrikoides blooms on eastern Long Island, NY USA 显示文摘 | GOBLER C J BERRY D L ANDERSON O R | 2008 | Harmful Algae2008，7，： | 1 |
| 15 | A simplified method for calculating the Debye temperature from elastic constants显示文摘 | ANDERSON O L | 1963 | Journal of Physics and Chemistry of Solids1963，24，7： | 1 |
| 16 | On the logic of the decomposition of statistical series into separate components显示文摘 | Anderson O | | 0，，03： | 1 |
| 17 | An improved standing-wave-type sloshing absorber 显示文摘 | ANDERSON J SEMERCIGIL S TURAN O | 2000 | Journal of Sound and Vibration2000，235，4： | 1 |
| 18 | Vectorial electron injection into transparent semiconductor membranes and electric field effects on the dynamics of light - induced charge separation 显示文摘 | Brian O'Regan Jacques Moser Marc Anderson | 1990 | J Phys Chem1990，94，： | 1 |
| 19 | Trace but not delay fear conditioning requires attention and the anterior cingulate cortex显示文摘 | Han C J O'Tuathaigh C M Anderson D J | 2003 | Proc Natl Acad Sci USA2003，100，13： | 1 |
| 20 | The Thermo-Calc databank system显示文摘 | SUNDMAN B JANSSON B ANDERSON J O | 1985 | CALPHAD1985，9，2： | 1 |
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