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| 1 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 2 | A Chaos Sparrow Search Algorithm with Logarithmic Spiral and Adaptive Step for Engineering Problems显示文摘The sparrow search algorithm(SSA)is a newly proposed meta-heuristic optimization algorithm based on the sparrowforaging principle.Similar to other meta-heuristic algorithms,SSA has problems such as slowconvergence speed and difficulty in jumping out of the local optimum.In order to overcome these shortcomings,a chaotic sparrow search algorithm based on logarithmic spiral strategy and adaptive step strategy(CLSSA)is proposed in this paper.Firstly,in order to balance the exploration and exploitation ability of the algorithm,chaotic mapping is introduced to adjust the main parameters of SSA.Secondly,in order to improve the diversity of the population and enhance the search of the surrounding space,the logarithmic spiral strategy is introduced to improve the sparrow search mechanism.Finally,the adaptive step strategy is introduced to better control the process of algorithm exploitation and exploration.The best chaotic map is determined by different test functions,and the CLSSA with the best chaotic map is applied to solve 23 benchmark functions and 3 classical engineering problems.The simulation results show that the iterative map is the best chaotic map,and CLSSA is efficient and useful for engineering problems,which is better than all comparison algorithms. | Andi Tang Huan Zhou Tong Han Lei Xie | 2022 | Computer Modeling in Engineering & Sciences2022，，1： | 5 |
| 3 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 4 | ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis显示文摘The development of nanomedicines provides new opportunities for the treatment of atherosclerosis(AS)due to their great advantages such as the improved drug solubility,enhanced bioavailability and reduced side effects.Despite these advantages,nanomedicines are still facing some challenges.The problems remain in the short circulation life,lack of specific targeting and poor drug release controllability.In order to overcome the shortages of conventional nanomedicines,the combination of biomimetic strategy with smart nanoagents has been proposed.In light with the high reactive oxygen species(ROS)level in AS microenvironment and the fact that macrophages play a critical role in the pathogenesis of AS,we fabricated ROS-responsive biomimetic nanoparticles(NPs),which camouflaged macrophage membrane(MM)on ROS-responsive NPs loaded with rapamycin(RNPs)for potential application in AS therapy.The resulting ROSresponsive biomimetic NPs(MM/RNPs)exhibited favorable hydrodynamic size with negative surface charge,retained the functional proteins from MM,and showed ROS-responsive drug release.Because of the biomimetic camouflaging on surface,MM/RNPs could effectively escape from macrophages uptake and target to inflammatory endothelial cells.Meanwhile,MM/RNPs could inhibit the proliferation of macrophages and smooth muscle cells in vitro.Furthermore,the MM-coated NPs were found to be nontoxic in both cytotoxicity assay and in vivo toxicity evaluation.Consequently,these results demonstrated that MM/RNPs could be a potential candidate of drug delivery system for safe and effective anti-AS applications. | Dan Tang Yi Wang Andy Wijaya Boyan Liu Ali Maruf Jinxuan Wang Jianxiong Xu Xiaoling Liao Wei Wu Guixue Wang | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Vision-guided ocular growth in a mutant chicken model with diminished visual acuity显示文摘 | Eric R. Ritchey Christopher Zelinka Junhua Tang Jun Liu Kimberly A. Code Simon Petersen-Jones Andy J. Fischer | 2012 | Experimental Eye Research2012，，： | 1 |
| 7 | Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases显示文摘 | John R Somoza Robert J Skene Bradley A Katz Clifford Mol Joseph D Ho Andy J Jennings Christine Luong Andrew Arvai Joseph J Buggy Ellen Chi Jie Tang Bi-Ching Sang Erik Verner Robert Wynands Ellen M Leahy Douglas R Dougan Gyorgy Snell Marc Navre Mark W Knut | 2004 | Structure2004，，7： | 1 |
| 8 | 基于bq76925+MSP430G2xx2的3至6节电池管理系统显示文摘bq76925是一款适用于3~6节串联电池应用的专用模拟前端(AFE),其所提供的3个模拟输出可帮助微控制器轻松监控电池电压、电流以及温度。电池电压可针对VCOUT引脚进行电平转换、缩放和多路复用。电池电流可通过与电池组串联的传感电阻器进行监控。传感电阻器的电压可放大驱动至VIOUT引脚。VTB引脚可提供开关偏置,用于激励支持温度测量的热敏电阻器网络。 | Richard Tang Andy He | 2015 | 今日电子2015，0，1： | 0 |
| 9 | Coupling physics in machine learning to investigate the solution behavior of binary Mg alloys显示文摘The solution behavior of a second element in the primary phase(α(Mg))is important in the design of high-performance alloys.In this work,three sets of features have been collected:a)interaction features of solutes and Mg obtained from first-principles calculation,b)intrinsic physical properties of the pure elements and c)structural features.Based on the maximum solid solubility values,the solution behavior of elements inα(Mg)are classified into four types,e.g.,miscible,soluble,sparingly-soluble and slightly-soluble.The machine learning approach,including random forest and decision tree algorithm methods,is performed and it has been found that four features,e.g.,formation energy,electronegativity,non-bonded atomic radius,and work function,can together determine the classification of the solution behavior of an element inα(Mg).The mathematical correlations,as well as the physical relationships among the selected features have been analyzed.This model can also be applied to other systems following minor modifications of the defined features,if required. | Tao Chen Qian Gao Yuan Yuan Tingyu Li Qian Xi Tingting Liu Aitao Tang Andy Watson Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，10： | 0 |
| 10 | Water–solid contact electrification and catalysis adjusted by surface functional groups显示文摘Chemical functional groups on solid surfaces greatly influence contact electrification(CE)at water–solid interfaces.Previous studies of their effects mainly swapped materials or bonded related molecules to a substrate,introducing other factors of influence.This work aims at unambiguously demonstrating the role of functional groups in water-polymer CE.We study the contribution of functional groups,by using ion coupled plasma etching to modify a high-density polyethylene(HDPE)film,a polymer with a naturally quasi-null charge transfer ability.Fluoride(HDPE–F)and hydroxyl(HDPE–OH)functional groups are generated and endowed HDPE with charge withdrawing ability.HDPE–F withdraws 2.5–2.7 times more charges than HDPE–OH.Concurrently,the surface charges accumulated generate electrostatic forces,altering the droplets motion.This phenomenon provides another approach to study CE,helping to evaluate the contribution of electrons to solid–liquid CE.Finally,employing HDPE–F to perform contact-electro-catalysis shows its activity is 2.4 times higher than that of commercial fluorinated films. | Yusen Su Andy Berbille Zhong Lin Wang Wei Tang | 2024 | Nano Research2024，17，4： | 0 |
| 11 | Integrated genomic and transcriptomic analysis reveals genes associated with plant height of foxtail millet显示文摘Foxtail millet(Setaria italica)is an important C4 model crop;however,due to its high-density planting and high stature,lodging at the filling stage resulted in a serious reduction in yield and quality.Therefore,it is imperative to identify and deploy the genes controlling foxtail millet plant height.In this study,we used a semi-dwarf line 263A and an elite high-stalk breeding variety,Chuang 29 to construct an F2 population to identify dwarf genes.We performed transcriptome analysis(RNA-seq)using internode tissues sampled at three jointing stages of 263A and Chuang 29,as well as bulk segregant analysis(BSA)on their F2 population.A total of 8918 differentially expressed genes(DEGs)were obtained from RNA-seq analysis,and GO analysis showed that DEGs were enriched in functions such as‘‘gibberellin metabolic process”and‘‘oxidoreductase activity”,which have previously been shown to be associated with plant height.A total 593 mutated genes were screened by BSA-seq method.One hundred and seventy-six out of the 593 mutated genes showed differential expression levels between the two parental lines,and seven genes not only showed differential expression in two or three internode tissues but also showed high genomic variation in coding regions,which indicated they play a crucial role in plant height determination.Among them,we found a gibberellin biosynthesis related GA20 oxidase gene(Seita.5G404900),which had a single-base at the third exon,leading to the frameshift mutation at 263A.Cleaved amplified polymorphic sequence assay and association analysis proved the single-base in Seita.5G404900 co-segregated with dwarf phenotype in two independent F2 populations planted in entirely different environments.Taken together,the candidate genes identified in this study will help to elucidate the genetic basis of foxtail millet plant height,and the molecular marker will be useful for marker-assisted dwarf breeding. | Mengyuan Zhu Qiang He Mingjie Lyu Tiantian Shi Qian Gao Hui Zhi Huan Wang Guanqing Jia Sha Tang Xiliu Cheng Rui Wanga Andi Xu Haigang Wang Zhijun Qiao Jun Liu Xianmin Diao Ying Gao | 2023 | The Crop Journal2023，11，2： | 0 |
| 12 | Ultrafast laser-scanning time-stretch imaging at visible wavelengths显示文摘Optical time-stretch imaging enables the continuous capture of non-repetitive events in real time at a line-scan rate of tens of MHz—a distinct advantage for the ultrafast dynamics monitoring and high-throughput screening that are widely needed in biological microscopy.However,its potential is limited by the technical challenge of achieving significant pulse stretching(that is,high temporal dispersion)and low optical loss,which are the critical factors influencing imaging quality,in the visible spectrum demanded in many of these applications.We present a new pulse-stretching technique,termed free-space angular-chirpenhanced delay(FACED),with three distinguishing features absent in the prevailing dispersive-fiber-based implementations:(1)it generates substantial,reconfigurable temporal dispersion in free space(41 ns nm^(−1))with low intrinsic loss(o6 dB)at visible wavelengths;(2)its wavelength-invariant pulse-stretching operation introduces a new paradigm in time-stretch imaging,which can now be implemented both with and without spectral encoding;and(3)pulse stretching in FACED inherently provides an ultrafast all-optical laser-beam scanning mechanism at a line-scan rate of tens of MHz.Using FACED,we demonstrate not only ultrafast laser-scanning time-stretch imaging with superior bright-field image quality compared with previous work but also,for the first time,MHz fluorescence and colorized time-stretch microscopy.Our results show that this technique could enable a wider scope of applications in high-speed and high-throughput biological microscopy that were once out of reach. | Jiang-Lai Wu Yi-Qing Xu Jing-Jiang Xu Xiao-Ming Wei Antony CS Chan Anson HL Tang Andy KS Lau Bob MF Chung Ho Cheung Shum Edmund Y Lam Kenneth KY Wong Kevin K Tsia | 2016 | Light(Science & Applications)2016，5，1： | 0 |
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