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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 3 | 有氧运动联合阻抗运动对难治性高血压患者动态血压的降低作用更为持久:一项随机交叉试验显示文摘该研究比较有氧运动、阻抗运动及联合运动对难治性高血压(refractory hypertension,RH)和非难治性高血压(NON-RH)患者血压的短期影响。方法:招募患者20例(RH 10例和NON-RH 10例),随机进行三种运动训练或对照训练。试验训练结束后监测24h动态血压。结果:RH患者在有氧运动、阻抗运动及联合运动后动态血压降低。联合运动后日间和夜间动态血压均降低。有氧运动对日间血压的影响更为显著,而阻抗运动降低夜间血压的幅度较大。仅阻抗运动降低NON-RH患者的收缩压,三种运动均可降低舒张压。 | 袁源(摘译) 练桂丽(审校) Pires NF Coelho-Júnior HJ Gambassi BB deFaria APC Ritter AMV de Andrade Barboza C Ferreira-Melo SE Rodrigues B Júnior HM | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 4 | Is MIPO in humeral shaftfractures really safe?Postoperative ultrasonographic evaluation显示文摘 | Livani B Belangero W Andrade K | 2009 | Int Orthop2009，33，6： | 1 |
| 5 | DNA microarray anal-ysis of gene expression in alveolar epithelial cells in response toTNFalpha, LPS, and cyclic stretch显示文摘 | dos Santos CC Han B Andrade CF | 2004 | Physiol Genomics2004，19，3： | 1 |
| 6 | Preliminary study offlavonols in port wine grape varieties 显示文摘 | ANDRADE P B MENDES G FALCO V | 2001 | Food Chem2001，73，4： | 1 |
| 7 | Comparison of six-minute walk test in children with moderate/ severe asthma with reference values for healthy children显示文摘 | ANDRADE L B SILV A R G SALGADO T L B | 2014 | Jomal de Pediatria2014，90，3： | 1 |
| 8 | Growth of Thiobacillus ferrooxidans on solidmedium:Effects of some surface-active agents on colony formation显示文摘 | Mukai J K Andrade C B | 1992 | J Gen Apple Microbiol1992，38，： | 1 |
| 9 | Video-assisted thoracoscopic surgery is more favorable than thoracotomy for resection of clinical stageⅠnon-small cell lung cancer显示文摘 | Whitson B A Andrade R S Boettcher A | 2007 | Ann Thorae Surg2007，83，6： | 1 |
| 10 | Review of procedures involving sep- aration and preeoncentration for the determination of cadmium using spectrometric techniques 显示文摘 | Ferreira Srgio L C de Andrade Jailson B Korn Maria das Gracas A | 2007 | Journal of Hazardous Materials2007，145，3： | 1 |
| 11 | The early responses of VEGF and its receptors during acute lung injury:implication of VEGF in alveolar epithelial cell survival显示文摘 | Mura M Him B Andrade C F | 2006 | Critical Care2006，10，5： | 1 |
| 12 | HLA class Ⅱ genotype influences the type of liver injury in drug induced idiosyncratic liver disease显示文摘 | Andrade B Lucena MI Alonso A | 2004 | Hepatology2004，39，6： | 1 |
| 13 | Antiulcerogenic activity of Alchornea castaneaefolia:Effects on somatostatin,gastrin and prostaglandin显示文摘 | Hiruma-Lima C A Calvo T B Rodrigues C M Andrade F D Souza-Brito A R M | 2006 | Journal of Ethnopharmacology2006，104，1： | 1 |
| 14 | Video-assisted thoracoscopic surgery is more favorable than shoraeotomy for resection of clinical stage I non-small cell lung cancer显示文摘 | Whitson B A Andrade R S Boettcher A | 2007 | Ann Thorae Surg2007，83，6： | 1 |
| 15 | Efficient Organic Electrophosphorescent White Light Emitting Device with a Triple Doped Emissive Layer显示文摘 | D'ANDRADE B W HOLMES R J FORREST S R | 2004 | Adv Mater2004，16，7： | 1 |
| 16 | Tools for genetic manipulation of the plant growth- promoting bacterium Azospirillum arnazonense 显示文摘 | Sant' Anna F H Andrade D S Trentini D B | 2011 | BMC Microbiology2011，11，： | 1 |
| 17 | Group B streptococcus GAPDH is released upon cell lysis,associates with bacterial surface,and induces apoptosis in murine macrophages显示文摘 | OLIVEIRA L MADUREIRA P ANDRADE E B | 2012 | PLo S One2012，7，29： | 1 |
| 18 | Changes in epi- phytic bacterial communities of intertidal seaweeds modulated by host,temporality, and copper enrichment显示文摘 | Hengst M B Andrade S Gonzalez B | 2010 | Microbial Ecology2010，60，2： | 1 |
| 19 | Effects of transport time and rest period on the quality of electrically stimulated male cattle carcasses显示文摘 | FERREIRA G B ANDRADE C L COSTA F | 2006 | Meat Science2006，74，3： | 1 |
| 20 | Scintillation mechanism of Tb3+doped Ba Y2F8显示文摘 | Ana C S de Mello Adriano B Andrade | 2010 | Optical Materials2010，32，： | 1 |
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