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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Arbutin-2'-sulphonyl from the infusion of llex theezans leaves 显示文摘 | ANDRADE F D P PIACENTE S PIZZA C | 2004 | Fitoterapia2004，，78： | 1 |
| 3 | Purification process of stevioside using zeolites and membranes显示文摘 | SILVA F V BERGAMASCO R ANDRADE C M G | 2007 | International Journal of Chemical Reactor Engineering2007，5，1： | 1 |
| 4 | A novel model for posttransplant obliterative airway disease reveals angiogenesis from the pulmonary circulation 显示文摘 | Dutly A E Andrade C F Verkaik R | 2005 | Am J Transplant2005，5，2： | 1 |
| 5 | Clarification and purification of aqueous Stevia extract using membrane separation process 显示文摘 | REIS M H M SILVA F V ANDRADE C M G | 2009 | Journal of Food Process Engineering2009，32，3： | 1 |
| 6 | Cover cracking as a function of bar corrosion : Part 2-numberical model 显示文摘 | Molina F J Alonso C Andrade C | 1993 | Materials and Struc- tures1993，163，26： | 1 |
| 7 | The early responses of VEGF and its receptors during acute lung injury:implication of VEGF in alveolar epithelial cell survival显示文摘 | Mura M Him B Andrade C F | 2006 | Critical Care2006，10，5： | 1 |
| 8 | Synthesis of aNiFe204 catalyst for the preferential oxidation of carbon monoxide (PROX)显示文摘 | SANTOS P T A COSTA A C F M KIMINAMI R H G A ANDRADE H M C LIRA H L GAMA L | 2009 | Journal of Alloy and Compounds2009，483，12： | 1 |
| 9 | Analysis of tool wear, surface roughness and cutting power in the turning process of compact graphite irons with different titanium content显示文摘 | DO N R DINIZ A E ANDRADE C L F | 2010 | Journal of the Brazilian society of mechanical sciences and engineering2010，32，3： | 1 |
| 10 | Antiulcerogenic activity of Alchornea castaneaefolia:Effects on somatostatin,gastrin and prostaglandin显示文摘 | Hiruma-Lima C A Calvo T B Rodrigues C M Andrade F D Souza-Brito A R M | 2006 | Journal of Ethnopharmacology2006，104，1： | 1 |
| 11 | A socioeconomic and natural vulnerability index for oil spills in an Amazonian harbor: a case study using GIS and remote sensing显示文摘 | DE ANDRADE M M N SZLAFSZTEIN C F SOUZA-FIL- HOP W M | 2010 | Journal of Environmental Man- agement2010，91，10： | 1 |
| 12 | Effects of transport time and rest period on the quality of electrically stimulated male cattle carcasses显示文摘 | FERREIRA G B ANDRADE C L COSTA F | 2006 | Meat Science2006，74，3： | 1 |
| 13 | Seed number as a funclion of growtih: A comparative study in soybean, sun flower and maiz显示文摘 | Vega C R C Andrade F H Sadras V O | 2001 | Crop Sci2001，41，： | 1 |
| 14 | Arbutin-2-sulphony from the infusion of Ilex theezans leaves显示文摘 | Andrade F D Piacents S Pizza C | 2004 | Fitoterapia2004，75，78： | 1 |
| 15 | Transcription of PR3 and Related Myelopoiesis Genes in Peripheral Blood Mononuclear Cells in Active Wegeners Granulomatosis显示文摘 | Cheadle C Berger AE Andrade F | 2010 | Arthritis Rheumatism2010，62，6： | 1 |
| 16 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin显示文摘 | Celeghini E C de Arruda R P de Andrade A F Nascimento J Raphael C F Rodrigues P H | | 0，，： | 1 |
| 17 | The role of free radicals in sepsis development显示文摘 | Andrades ME Ritter C Dal-Pizzol F | 2009 | Front Biosci (Elite Ed)2009，1，1： | 1 |
| 18 | Stem water storage and diurnal patterns of water use in tropical forest canopy trees 显示文摘 | Goldstein G Andrade J L Meinzer F C | 1998 | Plant Cell Environ1998，21，4： | 1 |
| 19 | Fibrous histiocytomas : histopathologic review of 95 cases 显示文摘 | Canelas M M Cardoso J C Andrade P F | 2010 | An Bras Dermatol2010，85，2： | 1 |
| 20 | DNA microarray analysis of gene expression in alveolar epithelial cellsin response to TNF-ct, LPS, and cyclic stretch 显示文摘 | Santos B Han C Andrade F | 2004 | Physiol Genomics2004，19，5： | 1 |
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