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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Heavy metal sorption and desorption capacity of soils containing endogenous contaminants 显示文摘 | COVELO E F VEGA F A ANDRADE M L | 2007 | Journal of Hazardous Materials2007，143，： | 1 |
| 3 | Proteomic anal- ysis of the cambial region in juvenile Eucalyptus grandis at three ages 显示文摘 | Celedon P A F de Andrade A Meireles K G X | 2007 | Proteomics2007，7，13： | 1 |
| 4 | Incorporation of V, Zn and Pb into the crystalline phases of Portland clinker 显示文摘 | ANDRADE F R D MARINGOLO V KIHARA Y | 2003 | Cem Concr Res2003，33，1： | 1 |
| 5 | Simultaneous mandibular and maxillary distraction in hemifacial microsomia in adults:avoiding occlusal disasters显示文摘 | Ortiz Monasterio F Molina F Andrade L | 1997 | Plast Reeonstr Surg1997，100，4： | 1 |
| 6 | Natural occurrence of abscisic acid in heather honey and floral nectar显示文摘 | Ferreres F Andrade P Franeisco A | 1996 | J Agric FoodChem1996，44，： | 1 |
| 7 | Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of routine macrophages 显示文摘 | Cerea F Andrade F Franea A | 2011 | J Med Microbiol2011，60，12： | 1 |
| 8 | Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication 显示文摘 | SOARES J A LEITE F G ANDRADE L G | 2009 | J Virol2009，83，13： | 1 |
| 9 | Arbutin-2'-sulphonyl from the infusion of llex theezans leaves 显示文摘 | ANDRADE F D P PIACENTE S PIZZA C | 2004 | Fitoterapia2004，，78： | 1 |
| 10 | Successful preservation of fertility subsequent to a complete pathologic response of a squamous cell carcinama of the uterine cervix treated with primary systemic chemotherapy显示文摘 | Andrade J M Marana H R Mangieri L F | 2000 | Gynecol Oncol2000，77，1： | 1 |
| 11 | Purification process of stevioside using zeolites and membranes显示文摘 | SILVA F V BERGAMASCO R ANDRADE C M G | 2007 | International Journal of Chemical Reactor Engineering2007，5，1： | 1 |
| 12 | Editorial Comment to Chronic bacterial seminal vesiculitis as a potential disease entity in men with chronic prostatitis 显示文摘 | Andrade Rocha F T | 2015 | International Journal of Urology2015，22，5： | 1 |
| 13 | Apollonian networks:simultaneously scale-free,small world,euclidean,space filling, and with matching Graphs显示文摘 | Andrade Jr J S Herrmann H J Andrade R F S | 2005 | Physical Review Letters2005，94，： | 1 |
| 14 | A novel model for posttransplant obliterative airway disease reveals angiogenesis from the pulmonary circulation 显示文摘 | Dutly A E Andrade C F Verkaik R | 2005 | Am J Transplant2005，5，2： | 1 |
| 15 | Clarification and purification of aqueous Stevia extract using membrane separation process 显示文摘 | REIS M H M SILVA F V ANDRADE C M G | 2009 | Journal of Food Process Engineering2009，32，3： | 1 |
| 16 | Cover cracking as a function of bar corrosion : Part 2-numberical model 显示文摘 | Molina F J Alonso C Andrade C | 1993 | Materials and Struc- tures1993，163，26： | 1 |
| 17 | Competitive sorption and desorption of heavy metals by individual soil components显示文摘 | Covelo E F Vega F A Andrade M L | 2007 | Journal of Hazardous Materials2007，140，1： | 1 |
| 18 | A sensitive flow analysis system for the fluorimetric determination of low levels of formaldehyde in alcoholic beverages显示文摘 | OLIVEIRA D F S SOUSA E ANDRADE D J | 2007 | Talanta2007，73，3： | 1 |
| 19 | The early responses of VEGF and its receptors during acute lung injury:implication of VEGF in alveolar epithelial cell survival显示文摘 | Mura M Him B Andrade C F | 2006 | Critical Care2006，10，5： | 1 |
| 20 | Equilibrium studies for the sorption of chromium and nickel from aqueous solutions using raw rice bran显示文摘 | OLIVEIRA E A MONTANHER S F ANDRADE A D | 2005 | Process Biochem2005，40，： | 1 |
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