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| 1 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Improved strategy for presumptive identification of methanogens using16S riboprinting显示文摘 | Andre D G Wright C P | 2003 | Journal of Microbiological Methods2003，，55： | 1 |
| 5 | Expression of the receptor protein tyrosine kinase myk-1/htk in normal andmalignant mammary epithelium 显示文摘 | Berclaz G Andres AC Albrecht D | 1996 | Biochem Biophys ResCommun1996，226，3： | 1 |
| 6 | A new and rapid colorimetric determination of acetylcholinesterase activity 显示文摘 | Ellman G L Courtney K D Andres V | 1961 | Biochemical Pharmacology1961，7，： | 1 |
| 7 | A new and rapid colorimetric determination of acetylcholinesterase activity显示文摘 | Ellman G L Courtney K D Andres Jr V | 1961 | Biochem Pharmacol1961，7，2： | 1 |
| 8 | A comparison of Northern Hemisphere winds using SuperDARN meteor trail and MF radar wind measurements显示文摘 | Hussey G C Meek C E André D | 2000 | Journal of Geophysical Research: Atmospheres (1984–2012)2000，105，18： | 1 |
| 9 | A new and rapid colorimetric determination of acetylcholine esterase activity显示文摘 | Ellman G L Courtney K D Andres V | 1961 | Biochemical Pharmacology1961，7，2： | 1 |
| 10 | Analysis of 13000 unique citrus clusters associated with fruit quality ,production and salinity tolerance显示文摘 | TEROL J CONESA A COLMENERO J CERCOS M TADEO F AGUSTI J ALOS E ANDRES F SOLER G BRUMOS J IGLESIAS D GOTZ S LEGAZ F ARGOIUT X COURTOIS B OLLITRAULT P DOSSART C WINCKER P MORILLON R TALON M | 2007 | BMC Genomics2007，8，： | 1 |
| 11 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 12 | A new and rapid colorimetric determination of an acetylcholinesterase activity 显示文摘 | ELLMAN G L COURTNEY K D ANDRES V J | 1961 | Biochemical Pharmacology1961，7，： | 1 |
| 13 | Inflammatory cells andchemokines sustain FGF2-induced angiogenesis 显示文摘 | Presta M Andres G Leali D | 2009 | EurCytokine Netw2009，20，2： | 1 |
| 14 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 15 | A new and rapid colorimetric determination of ace- tylcholinesterase activity 显示文摘 | ELLMAN G L COURTNEY K D ANDRES V | 1961 | Biochem Pharmacol1961，7，2： | 1 |
| 16 | Prognostic significance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: Systematic review and meta-analysis显示文摘 | Dániel Aradi András Komócsi András Vorobcsuk Orsolya Rideg Margit T?kés-Füzesi Tamás Magyarlaki Iván Gábor Horváth Victor L. Serebruany | 2010 | American Heart Journal2010，，3： | 1 |
| 17 | A new and rapid colorimetric determination of acetylcholinesterase activity显示文摘 | Ellman G L Courtney K D Andres Jr V | 1961 | Biochem Pharmacol1961，7，2： | 1 |
| 18 | A new and rapid colorimetric determination of acetylcholinesterase activity显示文摘 | Ellman G L Courtney D Andres V | 1961 | Biochem Pharmacol1961，7，： | 1 |
| 19 | A linked - modeling framework to estimate maize production risk associated with ENSO related climate variability in Argentina显示文摘 | Andres Ferreyra R Podesta G P Messina C D | 2001 | Agricultural and Forest Meteorology2001，107，3： | 1 |
| 20 | A new and rapid colorimetric determination of acetylcholinesterases activity 显示文摘 | Ellman G L Courtney K D Andres V Jr | 1961 | Biochemical Pharmacology1961，7，： | 1 |
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