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| 1 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | The Treatment of Intertrochanteric Fractures: Results Using an Intramedullary Nail With Integrated Cephalocervical Screws and Linear Compression显示文摘 | Andreas H Ruecker M Rupprecht M Gruber M Gebauer F Barvencik D Briem J M Rueger | 2009 | Journal of Orthopaedic Trauma2009，，1： | 2 |
| 5 | Application of optical-fiber temperature logging-An example in a sedinentary environment 显示文摘 | Andrea Forster Schrotter J Merriam D F | 1997 | Geophysics1997，62，4： | 1 |
| 6 | Reviews of Effects of RF Fields on Various Aspects of Human Health: Introduction显示文摘 | CHOU C K D'ANDREA J A | 2003 | Bioelectromagnetics2003，6，1： | 1 |
| 7 | Lifestyle Physical Activity Interventions: History, Short- and Long-term Effects, and Recommendations显示文摘 | Andrea L D Ross E A John M J | 1998 | American Journal of Preventive Medicine1998，15，4： | 1 |
| 8 | Relationship of energy settings and impedance in different anatomic areas using a radiofrequency device显示文摘 | LACK E B RACHEL J D D'ANDREA L | 2005 | Dermatol Surg2005，31，12： | 1 |
| 9 | Thermally Stable Blends of Fischer Tropsch and LCO Diesel Fuel Components显示文摘 | Dennis J John D Andrea N | 2004 | Energy&Fuels2004，18，： | 1 |
| 10 | The soybean's on behalf thanks the path analysis显示文摘 | Andrea J D | 1998 | FEBS Lettes1998，436，： | 1 |
| 11 | Mixed metal cyanide complexes derived from the CpCo(CN)3^- anion显示文摘 | Donald J D Andrea L P | 2004 | Inorganica Chemica Acta2004，357，5： | 1 |
| 12 | Targeted intra-operative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding显示文摘 | BELLETTI B VAIDYA J S D'ANDREA S | 2008 | Clin Cancer Res2008，14，5： | 1 |
| 13 | Can sedimentary leaf waxesrecord D/H ratios of continental precipitation?Field,model,andexperimental assessments显示文摘 | Hou J Z D'Andrea W J Huang Y S | 2008 | Geochimica et Cosmochimica Acta2008，72，14： | 1 |
| 14 | Impoundment failure seepage analyses 显示文摘 | Hagerty D J Andrea Curini | 2004 | Environmental & Engineering Geoscience2004，，1： | 1 |
| 15 | Localization of roteinase-aetivated receptors 1 and 2 in human mast cells: indica- tions foran amplified mast cell degranulation cascade显示文摘 | D' Andrea MR Rogahn C J Andrade-Gordon P | 2000 | Biotech Histochem2000，75，2： | 1 |
| 16 | Long chain alkenones in Greenland lake sediments: Low 813C values and exceptional abundance 显示文摘 | William J D' Andrea Huang Yongsong | 2005 | Organic Geochemistry2005，36，： | 1 |
| 17 | The Role of Topical Retinoids in theTreatment of photoaging显示文摘 | Alexander J Stratigos Andreas D | 2005 | Drugs2005，65，8： | 1 |
| 18 | Alkenone producers inferred from well-preserved 18S rDNA in Greenland lake sediments 显示文摘 | William J D'Andrea Melissa Lage Jennifer B H Martiny | 2006 | Journal of Geophysical Research2006，111，： | 1 |
| 19 | Climate change and recent waler level variability in Patagonian proglacial lakes, Argentina 显示文摘 | Andrea I P Karina L L Pedro J D | 2008 | Global and Planetary Change2008，63，4： | 1 |
| 20 | Absorption of quercetin- 3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter显示文摘 | Andrea J D Jennifer M G DuPont M S | 2003 | Biochem Pharmaeol2003，65，： | 1 |
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