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| 1 | Helicobacter pylori and autoimmune disease:Cause or bystander显示文摘Helicobacter pylori(H.pylori)is the main cause of chronic gastritis and a major risk factor for gastric cancer.This pathogen has also been considered a potential trigger of gastric autoimmunity,and in particular of autoimmune gastritis.However,a considerable number of reports have attempted to link H.pylori infection with the development of extra-gastrointestinal autoimmune disorders,affecting organs not immediately relevant to the stomach.This review discusses the current evidence in support or against the role of H.pylori as a potential trigger of autoimmune rheumatic and skin diseases,as well as organ specific autoimmune diseases.We discuss epidemiological,serological,immunological and experimental evidence associating this pathogen with autoimmune diseases.Although over one hundred autoimmune diseases have been investigated in relation to H.pylori,we discuss a select number of papers with a larger literature base,and include Sj grens syndrome,rheumatoid arthritis,systemic lupus erythematosus,vasculitides,autoimmune skin conditions,idiopathic thrombocytopenic purpura,autoimmune thyroid disease,multiple sclerosis,neuromyelitis optica and autoimmune liver diseases.Specific mention is given to those studies reporting an association of anti-H.pylori antibodies with the presence of autoimmune disease-specific clinical parameters,as well as those failing to find such associations.We also provide helpful hints for future research. | Daniel S Smyk Andreas L Koutsoumpas Maria G Myt-ilinaiou Eirini I Rigopoulou Lazaros I Sakkas Dimitrios P Bogdanos | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 2 | Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography显示文摘BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese subjects.AIM To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography Consensus.RESULTS Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular filtration rate(HR 0.98, 95%CI 0.96-0.99; P= 0.023), peak metabolic equivalents(HR 0.83, 95%CI 0.70–0.99, P = 0.034) and moderate mitral regurgitation(HR 5.02, 95%CI 1.42–17.75, P = 0.012).CONCLUSION Subclinical atherosclerosis defined by CP predicts AE in obese patients with negative EE. These patients could benefit from aggressive prevention measures. | Rafael Vidal-Perez Raúl Franco-Gutiérrez Alberto J Pérez-Pérez Virginia Franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María Testa-Fernández Carlos González-Juanatey | 2019 | World Journal of Cardiology2019，11，1： | 7 |
| 3 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 4 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 5 | A poly- morphism in the VKORC1 gene is associated with an interindivid- ual variability in the dose anticoagulant effect of warfarin 显示文摘 | D'ANDREA G D'AMBROSIO R L DI PEMA P | 2005 | Blood2005，1，5： | 1 |
| 6 | Cloning and characterisation of GPD2,a second gene encoding sn-glycerol 3-phosphate dehydrogenase (NAD^+) in Saccharomyces cerevisiae,and its comparison to GPD1显示文摘 | Eriksson P AndreA L Ansell R | 1995 | Mol Microbiol1995，17，1： | 1 |
| 7 | Minimal processing of a Granny Smith apple puree by microwave heating显示文摘 | PIERRE A P ANDREAS L MARIBEL A | 2009 | Innovative Food Science and Emerging Technologies2009，10，4： | 1 |
| 8 | Pseudomonas aeruginosa bloodstream infections: risk factors and treatment outcome related to the expression of the PER-1 extended-spectrum beta-lactamase显示文摘 | Andrea E Francesco L Beatrice P | 2006 | BMC Infect Dis2006，6，1： | 1 |
| 9 | In vivo RNA interference-mediated ablation of MDR1 and P-glycoprotein显示文摘 | Andrea P Noam Z Julin L | 2005 | Clin Cancer Res2005，15，6： | 1 |
| 10 | A bulk turbulent air sea flux algorithm for high-wind, spray conditions 显示文摘 | Andreas E L Persson P O G Hare J E | 2008 | J Phys Oceanogr2008，38，： | 1 |
| 11 | Sensing Behavior of Tetrakis (4-Sulfonatophenyl) Porphyrin Thin Films显示文摘 | Giovanna D L Gianmichele P Andrea R | 2006 | Chem Mater2006，18，8： | 1 |
| 12 | Mixed metal cyanide complexes derived from the CpCo(CN)3^- anion显示文摘 | Donald J D Andrea L P | 2004 | Inorganica Chemica Acta2004，357，5： | 1 |
| 13 | Routine workflow for use of urine strips and urine flow cytometer UF-100 in the hospital laboratory显示文摘 | Andreas L Reinhard Z Friedrich P | 1999 | Clin Chem1999，45，： | 1 |
| 14 | Routine workflow for use of urine slrips and urine flow cytometer UF-100 in the hospital laboralory显示文摘 | Andreas L Reirlhard Z Friedrichi P | 1999 | Clin Chem1999，45，： | 1 |
| 15 | Controlled release of doxorubicin loaded within magnetic thermo-responsive nanocarriers under magnetic and thermal actuation in a microfluidic channel显示文摘 | Manuel P L Andrea T Andreas R | 2012 | ACS Nano2012，6，10： | 1 |
| 16 | A new model for predicting acute mucosal toxicity in head-and-neck cancer patients undergoing radiotherapy with altered schedules显示文摘 | Strigari L Pedicini P D’Andrea M | 2012 | Int J Radiat Oncol Biol Phys2012，83，5： | 1 |
| 17 | Chloroform fumigation and the release of soil nitrogen: A rapid direct extraction method to measure microbial biomass nitrogen in soil显示文摘 | Brookes P C Andrea L Pruden G | 1985 | Soil Biology and Biochemistry1985，17，6： | 1 |
| 18 | Real-time motion detection based on SW/HW-codesign for walking rescue robots显示文摘 | JOHNY P ANDREAS L CLAUS C | 2013 | Journal of Real-Time Image Processing2013，8，4： | 1 |
| 19 | Climate change and recent waler level variability in Patagonian proglacial lakes, Argentina 显示文摘 | Andrea I P Karina L L Pedro J D | 2008 | Global and Planetary Change2008，63，4： | 1 |
| 20 | Chloroform fumigation and the release of soil nitrogen: A rapid direct extraction method to measure microbial biomass nitrogen in soil显示文摘 | Brookes P C Andrea L Pruden G | 1985 | Soil Biology and Biochemistry1985，17，6： | 1 |
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