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| 1 | Effect of percutaneous endoscopic gastrostomy on gastroesophageal reflux in mechanically-ventilated patients显示文摘瞄准:在机械地通气的病人在胃的食道的倒流(GER ) 上调查经皮的内视镜的胃造口术(木钉) 的效果。方法:在未来的、使随机化的、控制研究有周期性或坚持的联系通风机的肺病(VAP ) 和 GER >
的 36 个病人 6% 被划分成木钉组(n = 16 ) 或非木钉组(n = 20 ) 。11 通气了没有倒流的病人(GER <
3%) 用作控制组。食道的 pH-metry 被执行由在基线“渡过”方法,在木钉以后的 2 和 7 d。病人们严格地被跟随在上面为胃的滋养的残余的半侧卧的位置和控制。结果:median (范围)的重要减少倒流从 7.8 在木钉组被观察( 6.2 - 15.6 )在到 2.7 的基线( 0 - 10.4 )在 d 上 7 post-gastrostomy ( P <
0.01 ),当倒流从 9 增加了时( 6.2 - 22 )到 10.8 ( 6.3 - 36.6 )( P <
0.01 )在非木钉组。在 GER (%) 和 nasogastric 试管的停留之间的重要关联被检测(r = 0.56, P <
0.01 ) 。结论:胃造口术什么时候与滋养的胃的残余的半侧卧的位置和缺席结合了,在通气病人减少胃的食道的倒流。 | Emmanuel E Douzinas Andreas Tsapalos Antonios Dimitrakopoulos Evanthia Diamanti-Kandarakis Alexandros D Rapidis Charis Roussos | 2006 | World Journal of Gastroenterology2006，12，1： | 15 |
| 2 | Advances in hepatitis C therapy: What is the current state-what come's next?显示文摘Chronic hepatitis C virus(HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease.It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin.However,treatment of HCV has undergone a revolutionary change in recent years.The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents(DAA).Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure.High rates of sustained virological response(SVR) rates can be achieved with these novel drugs.Even in difficult to treat populations such as patients with liver cirrhosis,HCV-human immunodeficiency virus co-infections,after liver transplantion,or with chronic kidney disease comparable high rates of SVR can be achieved.The anticipated 2nd generation DAAs are strikingly effective in patients so far classified as difficult to treat including decompensated liver cirrhosis or posttransplant patients.These 2nd generations DAAs will have higher resistance barriers,higher antiviral effects and a pan-genotypic spectrum.This review highlights the current state of the art of antiviral treatment in hepatitis Cand gives an outlook for upcoming therapies. | Steffen Zopf Andreas E Kremer Markus F Neurath Juergen Siebler | 2016 | World Journal of Hepatology2016，8，3： | 7 |
| 3 | 油膜轴承变形和压力分析显示文摘轧机油膜轴承最新试验结果表明,实测油膜厚度比计算机模型预测值大3~5倍。这意味着,油膜厚度增加是由于锥套和衬套变形的结果,这种变形会导致锥套和衬套压力场扩大,进而导致油膜厚度增加。如果油膜厚度真的比预想的高3~5倍,则不但可以充分利用轴承固有的安全系数,而且还可以提高轴承的最大运行负荷。为确认试验结果,DanOil油膜轴承工程师构建了因液体动压场变化而导致的锥套变形模型,然后将这种变形用于复杂的计算机轴承模拟程序,来计算新的压力场。对压力场和锥套变形进行重复迭代计算,直到计算结果收敛为止。介绍了这一分析方法和计算结果。 | Thomas E Simmons Andrea Contarini Nonino Gianni 苏宏蕾 | 2009 | 钢铁2009，44，3： | 7 |
| 4 | Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro显示文摘瞄准:调查 cyclosporine 的效果 A (CsA )(MMF ) , FK-506,和 mycophenolate mofetil 和 40-0-[2-hydroxyethyl ] 人的肝内的增长上的 rapamycin (RAD ) 胆汁的上皮细胞(BEC ) 在试管内。方法:BEC 与免疫从六个人的肝织物标本被孤立磁性的分离方法并且与 CsA, FK-506, RAD,和 MMF 在试管内的不同集中对待。房间的增长被 MTT 试金分别地在 24 和 48 h 术后疗法测量。变化的单程的分析被用来分析结果。在 BEC 的 CK 19 的表示被流动血细胞计数和西方的污点监视。结果:BEC 的六根线被建立。他们为 4-18 wk 在试管内幸存。流动血细胞计数分析证明这些房间总是表示了 CK19。CsA, FK-506, RAD,和 MMF 以一种剂量依赖者方式禁止了 BEC 的增长。禁止 BEC (P<0.05 ) 的增长的 CsA, FK-506, RAD,和 MMF 的最低集中分别地是 500, 100, 0.25,和 100 mug/L。然而,由 BEC 的 CK19 的表示没被改变。结论:CsA, FK-506, RAD,和 MMF 在人的肝内 BEC 在试管内上有 antiproliferative 效果,当 RAD 有最强壮的生长禁止的效果时。他们在 transplant 病人的肝新生和胆汁管损害上的可能的效果应该进一步被调查。 | Chao Liu Thomas Schreiter Andrea Frilling Uta Dahmen Christoph E Broelsch Guido Gerken Ulrich Treichel | 2005 | World Journal of Gastroenterology2005，11，48： | 7 |
| 5 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 6 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 7 | Lipoma induced jejunojejunal intussusception显示文摘Intussusception in adults is rare. The clinical picture of intussusception in adults is subtle and the diagnosis is,therefore,elusive. The presence of a structural abnor- mality in the great majority of the adult cases mandates high clinical suspicion. Gastrointestinal lipomas are rare benign tumors and intussusception due to a gastrointes- tinal lipoma constitutes an infrequent clinical entity. The present report describes a case of jejunojejunal intus- susception in an adult with a history of severe episodes of hematochezia and colicky upper abdominal pain. The diagnosis was suspected preoperatively but computed tomography scan could not rule out malignancy. Explor- atory laparotomy revealed jejunojejunal intussusception secondary to a lipoma which was successfully treated with segmental intestinal resection. | Andreas Manouras Emmanuel E Lagoudianakis Dimitrios Dardamanis Dimitrios K Tsekouras Haridimos Markogiannakis Michael Genetzakis Nikolaos Pararas Artemisia Papadima Christos Triantafillou Vagelogiannis Katergiannakis | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 8 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 9 | Immunological roulette: Luck or something more? Considering the connections between host and environment in TB显示文摘Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research objective.From the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad luck.Here,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated systems.Most infected individuals who progress to disease have apparently good immune responses,but these responses are,at times,compromised by either local or systemic environmental factors.Obvious disease promoting processes,such as tissue-damaging granulomata,usually manifest in the lung,but illness is systemic.This apparent dichotomy between local and systemic reflects a clear need to define the factors that promote progression to active disease within the context of the body as a physiological whole.We discuss aspects of the host environment that can impact expression of immunity,including the microbiome,glucocorticoid-mediated regulation,catecholamines and interaction between the gut,liver and lung.We suggest the importance of integrating precision medicine into our analyses of experimental outcomes such that apparently conflicting results are not contentious,but rather reflect the impact of these subtle relationships with our environment and microbiota. | John E Pearl Mrinal Das Andrea M Cooper | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 10 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 11 | Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data显示文摘 | Andreas Hackethal Doerthe Brueggmann Michael K Bohlmann Folker E Franke Hans-Rudolf Tinneberg Karsten Münstedt | 2008 | Lancet Oncology2008，，12： | 2 |
| 12 | CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘 | Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse | 2012 | Eur J Immunol2012，，12： | 2 |
| 13 | Type 1 diabetes and celiac disease:The effects of gluten free diet on metabolic control显示文摘Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different studies.After a diagnosis of celiac disease is confirmed by small bowel biopsy,patients are advised to commence a gluten-free diet(GFD).This dietary restriction may be particularly difficult for the child with diabetes,but in Europe(and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD products.Treatment with a GFD in symptomatic patients has been shown to improve the symptoms,signs and complications of celiac disease.However,the effects of a GFD on diabetic control are less well established.Initial reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption,but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac disease.There are other studies reporting no effect,improved control and an improvement of hypoglycemic episodes.Moreover,in this review we wish to focus on low glycemic index foods,often suggested in people with type 1 diabetes,since they might reduce postprandial glycemic excursion and enhance longterm glycemic control.In contrast,GFD may be rich in high glycemic index foods that can increase the risk of obesity,insulin resistance and cardiovascular disease,worsening the metabolic control of the child with diabetes.Hence,it is important to evaluate the impact of a GFD on metabolic control,growth and nutritional status in children with type 1 diabetes. | Andrea E Scaramuzza Cecilia Mantegazza Alessandra Bosetti Gian Vincenzo Zuccotti | 2013 | World Journal of Diabetes2013，4，4： | 2 |
| 14 | 迟发性性腺功能减退症与骨化二醇的关系显示文摘男性迟发性性腺功能减退症是指具有血清睾酮(T)水平降低和典型临床症状的综合征。而血清睾酮浓度是否总能真实反应Leydig细胞的功能目前仍不确定。轻度睾丸改变只有通过检测额外的生化标记物如黄体生成素(LH)和25.羟维生素D才能确诊。这些标记物可以帮助诊断称之为“亚临床”型的性腺功能减退(血清睾酮正常,LH升高)。性腺功能减退患者通常由于睾丸中CYP2Rt羟化酶受损而具有较低水平的25.羟维生素D。然而,目前仍无证据阐释维生素D3亦或骨化二醇是治疗此类病人的最佳选择。因此我们分析了26位具有典型性腺功能减退患者(总T[TT]〈12nmol 1^-1,LH≥8IU 1^-1)及46位亚临床型性腺功能减退患者(TT≥12nmol 1^-1,LH≥8IU 1^-1)以及低25-羟维生素D患者(〈50nmol 1^-1)。其中20名患者接受每周5000IU的维生素D3治疗,46名患者接受每周4000IU的骨化二醇治疗。治疗3个月后,患者25-羟维生素D及甲状旁腺激素升高。在两组患者中(原发型16人,亚临床型30人)补充骨化二醇可以显著提高25-羟维生素D水平并显著降低甲状旁腺激素水平,而补充维生素D3的患者,其25-羟维生素D和甲状旁腺激素水平并无明显变化。本研究首次阐述服用骨化二醇而非维生素D3,可以提高男性迟发性性腺功能减退患者25-羟维生素D水平。 | Carlo Foresta Aldo E Calogero Francesco Lombardo Andrea Lenzi Alberto Ferlin | 2015 | Asian Journal of Andrology2015，17，2： | 2 |
| 15 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 16 | Mean platelet volume: a useful marker of inflammatory bowel disease activity显示文摘 | Andreas N Kapsoritakis Michael I Koukourakis Aekaterini Sfiridaki Spiros P Potamianos Maria G Kosmadaki Ioannis E Koutroubakis Elias A Kouroumalis | 2001 | The American Journal of Gastroenterology2001，，3： | 2 |
| 17 | Association of Helicobacter Pylori Infection and Colon Cancer显示文摘 | Alexandros Strofilas Emmanuel E Lagoudianakis Charalambos Seretis Apostolos Pappas Nikolaos Koronakis Dimitrios Keramidaris Ilias Koukoutsis Ioannis Chrysikos Ioannis Manouras Andreas Manouras | 2012 | Journal of Clinical Medicine Research2012，，3： | 2 |
| 18 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 19 | Realizing the hydrogen future: the International energy agency's efforts to advance hydrogen energy technologies显示文摘 | Carolyn C E Gary S Andreas L | 2003 | Int J Hydrogen Energy2003，28，： | 1 |
| 20 | Impact of osmotic/matric stress and heat shock on environmental tolerance induction of bacterial biocontrol agents against Fusarium vetticillioides显示文摘 | Melina S Andrea N Miriam E | 2010 | Research in Microbiology2010，，161： | 1 |
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