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| 1 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 2 | Therapy of gastric mucosa associated lymphoid tissue lymphoma显示文摘Gastric mucosa associated lymphoid tissue (MALT) lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success. | Andrea Morgner Renate Schmelz Christian Thiede Manfred Stolte Stephan Miehlke | 2007 | World Journal of Gastroenterology2007，13，26： | 14 |
| 3 | Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial显示文摘 | Ahmed Madisch Stephan Miehlke Otto Eichele Jenny Mrwa Birgit Bethke Eberhard Kuhlisch Elke B?stlein Georg Wilhelms Andrea Morgner Bernd Wigginghaus Manfred Stolte | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
| 4 | Differing degree and distribution of gastritis in Helicobacter pylori-associated diseases显示文摘 | Alexander Meining M. Stolte Rudolf Hatz Norbert Lehn Stephan Miehlke Andrea Morgner Ekkehard Bayerd?rffer | 1997 | Virchows Archiv1997，，1： | 1 |
| 5 | Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial显示文摘 | Ahmed Madisch Stephan Miehlke Otto Eichele Jenny Mrwa Birgit Bethke Eberhard Kuhlisch Elke B?stlein Georg Wilhelms Andrea Morgner Bernd Wigginghaus Manfred Stolte | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
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