|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 2 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 3 | Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies显示文摘 | Frank Kroschinsky Matthias Weise Thomas Illmer Mathias Haenel Martin Bornhaeuser Gert Hoeffken Gerhard Ehninger Ulrich Schuler | 2002 | Intensive Care Medicine2002，，9： | 1 |
| 4 | Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer显示文摘 | Mareike Florek Michael Haase Anne-Marie Marzesco Daniel Freund Gerhard Ehninger Wieland B. Huttner Denis Corbeil | 2005 | Cell and Tissue Research2005，，1： | 1 |
| 5 | Gene and haplotype frequencies for the loci HLA-A,HLA-B,and HLA-DR based on over 13,000 German blood donors显示文摘 | Carlheinz R Muller Gerhard Ehninger | 2003 | Hum Immunol2003，64，： | 1 |
| 6 | Clonal Heterogeneity As Detected by Metaphase Karyotyping Is an Indicator of Poor Prognosis in Acute Myeloid Leukemia显示文摘 | Tilmann Bochtler Friedrich St?lzel Christoph E. Heilig Christina Kunz Brigitte Mohr Anna Jauch Johannes W.G. Janssen Michael Kramer Axel Benner Martin Bornh?user Anthony D. Ho Gerhard Ehninger Markus Schaich Alwin Kr?mer | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 7 | Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and ?5/5q?显示文摘 | Jan M. Middeke Dietrich Beelen Michael Stadler Gudrun G?hring Brigitte Schlegelberger Herrad Baurmann Gesine Bug Frauke Bellos Brigitte Mohr Stefanie Buchholz Rainer Schwerdtfeger Hans Martin Ute Hegenbart Gerhard Ehninger Martin Bornh?user Johannes Schet | 2012 | Blood2012，，12： | 1 |
| 8 | Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation显示文摘 | Claudia Ortlepp Christine Steudel Caroline Heiderich Sina Koch Angela Jacobi Martin Ryser Sebastian Brenner Martin Bornh?user Benedikt Brors Wolf-Karsten Hofmann Gerhard Ehninger Christian Thiede | 2013 | Experimental Hematology2013，，5： | 1 |
| 9 | Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells显示文摘 | Friedrich St?lzel Christine Steudel Uta Oelschl?gel Brigitte Mohr Sina Koch Gerhard Ehninger Christian Thiede | 2010 | Annals of Hematology2010，，： | 1 |
| 10 | Expression profiling of gastric cancer samples by oligonucleotide microarray analysis reveals low degree of intra-tumor variability显示文摘AIM: Gene expression profiling provides an unique opportunity to gain insight into the development of different types of gastric cancer. Tumor sample heterogeneity is thought to decrease the sensitivity and tumor specificity of microarray analysis. Thus, microdissection and preamplification of RNA is frequently performed. However, this technique may also induce considerable changes to the expression profile. To assess the effect of gastric tumor heterogeneity on expression profiling results, we measured the variation in gene expression within the same gastric cancer sample by performing a gene chip analysis with two RNA preparations extracted from the same tumor specimen.METHODS: Tumor samples from six intestinal T2 gastric tumors were dissected under liquid nitrogen and RNA was prepared from two separate tumor fragments. Each extraction was individually processed and hybridized to an Affymetrix U133A gene chip covering approximately 18 000 human gene transcripts. Expression profiles were analyzed using Microarray Suite 5.0 (Affymetrix) and GeneSpring 6.0 (Silicon Genetics).RESULTS: All gastric cancers showed little variance in expression profiles between different regions of the same tumor sample. In this case, gene chips displayed mean pair wise correlation coefficients of 0.94±0.02 (mean±SD),compared to values of 0.61±0.1 for different tumor samples. Expression of the variance between the two expression profiles as a percentage of 'total change'(Affymetrix) revealed a remarkably low average value of 1.18±0.78 for comparing fragments of the same tumor sample.In contrast, comparison of fragments from different tumors revealed a percentage of 24.4±4.5.CONCLUSION: Our study indicates a low degree of expression profile variability within gastric tumor samples isolated from one patient. These data suggest that tumor tissue heterogeneity is not a dominant source of error for microarray analysis of larger tumor samples, making total RNA extraction an appropriate strategy for performing gene chip expression profiling of gastric cancer. | Karolin Trautmann Christine Steudel Dana Grossmann Daniela Aust Gerhard Ehninger Stephan Miehike Christian Thiede | 2005 | World Journal of Gastroenterology2005，11，38： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员