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| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 3 | Customer Rentention,Loyalty,and Satisfaction in the German Mobile Cellular Telecommunications market显示文摘 | Gerpott Torsten Wolfgang Rams Andreas Schindler | | 0，，： | 1 |
| 4 | Validation of Landslide Susceptibility Maps; Examples and Applications from a Case Study in Northern Spain显示文摘 | Juan Remondo Alberto González José Ramón Díaz De Terán Antonio Cendrero Andrea Fabbri Chang-Jo F. Chung | 2003 | Natural Hazards2003，，3： | 1 |
| 5 | Customer retention,loyalty and satisfaction in the German mobile cellular telecommunications market显示文摘 | Gerpott Torsten J Rams Wolfgang Schindler Andreas | 2001 | Telecommunications Policy2001，25，： | 1 |
| 6 | Comparative assessment of CO2capture technologies for carbon-intensive industrial processes显示文摘 | Kuramochi Takeshi Ramírez Andrea Turkenburg Wim | 2012 | Progress in Energy and Combustion Science2012，38，： | 1 |
| 7 | Customer retention, loyalty, and satisfaction in the German mobile cellular telecommunications market 显示文摘 | Torsten J Gerpott Wolfgang Rams Andreas Schindler | 2001 | Telecommunications Policy2001，25，： | 1 |
| 8 | Determining semantic similarity among entity classes from different ontologies 显示文摘 | Andrea RaM Egenhofer MJ | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，2： | 1 |
| 9 | The porous media model for the hydraulic system of a conifer tree: Linking sap flux data to transpiration rate显示文摘 | Yao-Li Chuang Ram Oren Andrea L. Bertozzi Nathan Phillips Gabriel G. Katul | 2005 | Ecological Modelling2005，，3： | 1 |
| 10 | Customer retention, loyalty, and satisfaction in the German mobile cellular telecommunications market 显示文摘 | Torsten J Gerpott Wolfgang Rams Andreas Schindler | 2001 | Telecommunications Policy2001，，25： | 1 |
| 11 | A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial显示文摘 | Rob Pieters Martin Schrappe Paola De Lorenzo Ian Hann Giulio De Rossi Maria Felice Liisa Hovi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Stary Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea | 2007 | The Lancet2007，，9583： | 1 |
| 12 | Customer retention, loyalty, and satisfaction in the German mobile cellular telecommunications market显示文摘 | Torsten J Gerpott Wolfgang Rams Andreas Schindler | 2001 | Telecommunications Policy2001，，4： | 1 |
| 13 | Beyond species loss: the extinction of ecological interactions in a changing world显示文摘 | Alfonso Valiente‐Banuet Marcelo A. Aizen Julio M. Alcántara Juan Arroyo Andrea Cocucci Mauro Galetti María B. García Daniel García José M. Gómez Pedro Jordano Rodrigo Medel Luis Navarro José R. Obeso Ramona Oviedo Nelson Ramírez Pedro J. Rey Anna Traveset | 2015 | Funct Ecol2015，，： | 1 |
| 14 | An inter-laboratory study of DNA-based identity,parentage and species testing in animal forensic genetics显示文摘The probative value of animal forensic genetic evidence relies on laboratory accuracy and reliability.Inter-laboratory comparisons allow laboratories to evaluate their performance on specific tests and analyses and to continue to monitor their output.The International Society for Animal Genetics(ISAG)administered animal forensic comparison tests(AFCTs)in 2016 and 2018 to assess the limitations and capabilities of laboratories offering forensic identification,parentage and species determination services.The AFCTs revealed that analyses of low DNA template concentrations(≤300 pg/μL)constitute a significant challenge that has prevented many laboratories from reporting correct identification and parentage results.Moreover,a lack of familiarity with species testing protocols,interpretation guidelines and representative databases prevented over a quarter of the participating laboratories from submitting correct species determination results.Several laboratories showed improvement in their genotyping accuracy over time.However,the use of forensically validated standards,such as a standard forensic short tandem repeat(STR)kit,preferably with an allelic ladder,and stricter guidelines for STR typing,may have prevented some common issues from occurring,such as genotyping inaccuracies,missing data,elevated stutter products and loading errors.The AFCTs underscore the importance of conducting routine forensic comparison tests to allow laboratories to compare results from each other.Laboratories should keep improving their scientific and technical capabilities and continuously evaluate their personnel’s proficiency in critical techniques such as low copy number(LCN)analysis and species testing.Although this is the first time that the ISAG has conducted comparison tests for forensic testing,findings from these AFCTs may serve as the foundation for continuous improvements of the overall quality of animal forensic genetic testing. | Sreetharan Kanthaswamy Torsten Brendel Luis Cancela Denise A.Andrade de Oliveira Bertram Brenig Carmen Cons Julian A.Crespi Markéta Dajbychová Andreas Feldl Tomohito Itoh Vincenzo Landi Amparo Martinez Malgorzata Natonek-Wisniewska Robert F.Oldt Anna Radko Oscar Ramírez Clementina Rodellar Manuel Ruiz-Girón David Schikorski María Elena Turba Guillermo Giovambatista | 2022 | Forensic Sciences Research2022，7，4： | 0 |
| 15 | From conventional two-stage hepatectomy to ALPPS:Fifteen years of experience in a hepatobiliary surgery unit显示文摘Background:Hepatectomy in patients with large tumor load may result in postoperative liver failure and associated complications due to excessive liver parenchyma removal.Conventional two-stage hepatectomy(TSH)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique are possible solutions to this problem.Colorectal liver metastases(CRLM)is the most frequent indication,and there is a need to assess outcomes for both techniques to improve surgical and long-term oncological outcomes in these patients.Methods:A single-center retrospective study was designed to compare TSH with ALPPS in patients with initially unresectable bilateral liver tumors between January 2005 and January 2020.ALPPS was performed from January 2012 onwards as the technique of choice.Long-term overall survival(OS)and disease-free survival(DFS)were evaluated as primary outcome in CRLM patients.Postoperative morbidity,mortality and liver growth in all patients were also evaluated.Results:A total of 38 staged hepatectomies were performed:17 TSH and 21 ALPPS.Complete resection rate was 76.5%(n=13)in the TSH group and 85.7%(n=18)in the ALPPS group(P=0.426).Overall major morbidity(Clavien-Dindo≥3 a)(stage 1+stage 2)was 41.2%(n=7)in TSH and 33.3%(n=7)in ALPPS patients(P=0.389),and perioperative 90-day mortalities were 11.8%(n=2)vs.19.0%(n=4)in each group,respectively(P=0.654).Intention-to-treat OS rates at 1 and 5 years in CRLM patients for TSH(n=15)were 80%and 33%,and for ALPPS(n=17)76%and 35%,respectively.DFS rates at 1 and 5 years were 36%and 27%in the TSH group vs.33%and 27%in the ALPPS group,respectively.Conclusions:ALPPS is an effective alternative to TSH in bilateral affecting liver tumors,allowing higher resection rate,but patients must be carefully selected.In CRLM patients similar long-term OS and DFS can be achieved with both techniques. | Javier Maupoey Ibáñez Eva María MontalváOrón Andrea BoscàRobledo Alonso Camacho Ramírez Ana Hernando Sanz Pablo Granero Castro Alberto Alegre Delgado Rafael López-Andújar | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，6： | 0 |
| 16 | 婴儿急性淋巴细胞白血病治疗方案(Interfant-99):一项多中心随机临床试验及观察研究显示文摘背景急性淋巴细胞白血病(ALL)极少见于1岁以内的婴儿,一旦患病其预后将比年长幼儿更差。本项国际研究旨在观察一种新的兼具ALL与急性髓系白血病(AML)治疗要素的混合治疗方案的应用效果,并确定可能影响婴儿预后的因素。本研究同时还进行了一项随机临床试验,以确定晚期强化治疗的,临床价值。
方法本研究包括来自22个国家的17个研究组,分别于1999-2005年选取年龄为0~12个月的ALL婴儿。根据前期泼尼松治疗7d后外周血的反应,对患儿进行风险分层,然后给予以ALL标准疗法为基础的混合治疗,该疗法亦包含某些AML治疗要素。在维持期之前,将完全缓解的一组患儿随机分为标准治疗组和应用高剂量阿糖胞苷及甲氨蝶呤的高强度化疗组。主要结局指标为初选治疗组的无事件生存率(EFS)与随机治疗组的无病存活率(DFS)。数据处理以意向治疗分析为基础。该试验在ClinicalTrials.gov网站上的注册号为NCT 00015873,在controlled—trials.com网站上注册号为ISRCTN24251487。
结果共计482例患婴接受混合治疗,其中260例(58%)完全缓解,中位随访期为38个月(极差1~78),4年EFS达47.0%(si=2.6,95%CI41.9%~52.1%)。诱导治疗5周后445例获完全缓解,入选随机分组191例,其中晚期强化治疗组95例,对照组96例。在中位数为42个月(极差1~73)的随访期后,治疗组无病存活60例,对照组57例。2组间4年DFS无显著差异[治疗组为60.9%(sx^-=5.2)VS对照组为57.0%;P=0.81]。在强化治疗期,71例随机治疗组患婴反馈有毒性统计数据,其中感染35例(49%)、黏膜炎21例(30%)、肝脏毒性反应22例(33%)、神经毒性2例(3%)。反映预后不佳的独立因素包括:各种M比(混合系白血病)基因重排、极高的白细胞计数、年龄〈6个月、前期泼尼松治疗反应差。
结论与多数报道相比,ALL婴儿(特别是那些对泼尼松反应差的患儿)接受混合治疗后可获得较好的EFS。但晚期强化化疗的效果并不明显。 | Rob Pieters Martin Schrappe Paola De Lorenzo lan Hann Giulio De Rossi Maria Felice Liisa Houi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Story Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea Biondi Ajay Vora Maria Grazia Valsecchi 王顺涛(译) | 2008 | 世界临床医学2008，2，1： | 0 |
| 17 | Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome显示文摘Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy response.Tumor endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in vivo.Here,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes. | Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp Charles Gwellem Anchang Richard Demmler Yanmin Lyu Steffen Uebe Arif Bülent Ekici Carol Immanuel Geppert Arndt Hartmann Christian Flierl Katja Petter Tobias Gass Simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera Simone Schellerer Michael Stürzl | 2023 | Cancer Communications2023，43，11： | 0 |
| 18 | Renal function assessment in atrial fibrillation:Usefulness of chronic kidney disease epidemiology collaboration vs reexpressed 4 variable modification of diet in renal disease显示文摘AIM: To compare the performance of the re-expressed Modification of Diet in Renal Disease equation vs the new Chronic Kidney Disease Epidemiology Collaboration equation in patients with non-valvular atrial fibrillation.METHODS: We studied 911 consecutive patients with non-valvular atrial fibrillation on vitamin-K antagonist. The performance of the re-expressed Modification of Diet in Renal Disease equation vs the new Chronic Kidney Disease Epidemiology Collaboration equation in patients with non-valvular atrial fibrillation with respect to either a composite endpoint of major bleeding, thromboembolic events and all-cause mortality or each individual component of the composite endpoint was assessed using continuous and categorical ≥ 60, 59-30, and < 30 m L/min per 1.73 m2 estimated glomerular filtration rate.RESULTS: During 10 ± 3 mo, the composite endpoint occurred in 98(10.8%) patients: 30 patients developed major bleeding, 18 had thromboembolic events, and 60 died. The new equation provided lower prevalence of renal dysfunction < 60 m L/min per 1.73 m2(32.9%),compared with the re-expressed equation(34.1%). Estimated glomerular filtration rate from both equations was independent predictor of composite endpoint(HR = 0.98 and 0.97 for the re-expressed and the new equation, respectively; P < 0.0001) and all-cause mortality(HR = 0.98 for both equations, P < 0.01). Strong association with thromboembolic events was observed only when estimated glomerular filtration rate was < 30 m L/min per 1.73 m2: HR is 5.1 for the re-expressed equation, and HR = 5.0 for the new equation. No significant association with major bleeding was observed for both equations.CONCLUSION: The new equation reduced the prevalence of renal dysfunction. Both equations performed similarly in predicting major adverse outcomes. | Rami Riziq-Yousef Abumuaileq Emad Abu-Assi Andrea López-López Sergio Raposeiras-Roubin Moisés Rodríguez-Manero Luis Martínez-Sande Francisco Javier García-Seara Xesus Alberte Fernandez-López Jose Ramón González-Juanatey | 2015 | World Journal of Cardiology2015，7，10： | 0 |
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