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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | Critical analysis of feeding jejunostomy following resection of upper gastrointestinal malignancies显示文摘AIM To assess nutritional recovery,particularly regarding feeding jejunostomy tube(FJT)utilization,following upper gastrointestinal resection for malignancy. METHODS A retrospective review was performed of a prospectively-maintained database of adult patients who underwent esophagectomy or gastrectomy(subtotal or total)for cancer with curative intent,from January 2001 to June 2014. Patient demographics,the approach to esophagectomy,the extent of gastrectomy,FJT placement and utilization at discharge,administration of parenteral nutrition(PN),and complications were evaluated. All patients were followed for at least ninety days or until death.RESULTS The 287 patients underwent upper GI resection,comprised of 182 esophagectomy(n=107 transhiatal,58.7%; n=56 Ivor-Lewis,30.7%)and 105 gastrectomy [n=63 subtotal(SG),60.0%; n=42 total(TG),40.0%]. 181 of 182 esophagectomy patients underwent FJT,compared with 47 of 105 gastrectomy patients(99.5% vs 44.8%,P < 0.0001),of whom most had undergone TG(n=39,92.9% vs n=8 SG,12.9%,P < 0.0001). Median length of stay was similar between esophagectomy and gastrectomy groups(14.7 d vs 17.1 d,P=0.076). Upon discharge,87 esophagectomy patients(48.1%)were taking enteral feeds,with 53(29.3%)fully and 34(18.8%)partially dependent. Meanwhile,20 of 39 TG patients(51.3%)were either fully(n=3,7.7%)or partially(n=17,43.6%)dependent on tube feeds,compared with 5 of 8 SG patients(10.6%),all of whom were partially dependent. Gastrectomy patients were significantly less likely to be fully dependent on tube feeds at discharge compared to esophagectomy patients(6.4% vs 29.3%,P=0.0006). PN was administered despite FJT placement more often following gastrectomy than esophagectomy(n=11,23.4% vs n=7,3.9%,P=0.0001). FJT-specific complications requiring reoperation within 30 d of resection occurred more commonly in the gastrectomy group(n=6),all after TG,compared to 1 esophagectomy patient(12.8% vs 0.6%,P=0.0003). Six of 7 patients(85.7%)who experienced tube-related complications required PN.CONCLUSION Nutritional recovery following esophagectomy and gastrectomy is distinct. Operations are associated with unique complication profiles. Nutritional supplementation alternative to jejunostomy should be considered in particular scenarios. | Andrew M Blakely Saad Ajmal Rachel E Sargent Thomas T Ng Thomas J Miner | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 4 |
| 3 | 'GrabCut'显示文摘 | Carsten Rother Vladimir Kolmogorov Andrew Blake | 2004 | ACM Transactions on Graphics (TOG)2004，，3： | 3 |
| 4 | Poisson image editing显示文摘 | Patrick Pérez Michel Gangnet Andrew Blake | 2003 | ACM Transactions on Graphics (TOG)2003，，3： | 2 |
| 5 | Real-time human pose recognition in parts from single depth images显示文摘 | Jamie Shotton Toby Sharp Alex Kipman Andrew Fitzgibbon Mark Finocchio Andrew Blake Mat Cook Richard Moore | 2013 | Communications of the ACM2013，，1： | 2 |
| 6 | Data Fusion for Visual Tracking with Particles 显示文摘 | Partick Perez Jaco Verrnaak Andrew Blake | 2004 | Proceedings of the IEEE (S0018-9219)2004，92，3： | 1 |
| 7 | Contour Tracking by Stochastic Propagation of Conditional Density显示文摘 | Michael Isard Andrew Blake | 1996 | European Conference on Computer Vision Cambridge1996，，4： | 1 |
| 8 | Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference显示文摘 | Andrews N Loomis S Blake R | 2001 | Psychopharmacology2001，157，4： | 1 |
| 9 | A two-facter model for stochastic mortality with parameter uncertainty,theory and calibration显示文摘 | David Blake Kevin Dowd | 2006 | The Journal of Risk and Insurance2006，73，4： | 1 |
| 10 | 'GrabCut'显示文摘 | Carsten Rother Vladimir Kolmogorov Andrew Blake | 2004 | ACM Transactions on Graphics (TOG)2004，，： | 1 |
| 11 | Poisson Image Editing显示文摘 | Patrick Peres Michel Gangnet Andrew Blake | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 12 | Effect of gabapentinlike compounds on development and maintenance of morphine-induced conditioned place preference显示文摘 | Andrews N Loomis S Blake R | 2001 | Psychopharmacology2001，157，： | 1 |
| 13 | Condensation-conditional density propagation for visual tracking显示文摘 | Isard Michael Blake Andrew | 1998 | Int J Computer Vision1998，29，1： | 1 |
| 14 | The moderating effects of equity sensitivity on the relationship between organizational justice and organizational citizenship behaviors显示文摘 | Blakely GL Andrews MC Moorman RH | | 0，，02： | 1 |
| 15 | Multiscale categorical object recognition using contour fragments显示文摘 | Jamie Shotton Andrew Blake | 2008 | IEEE Transaction on Pattern Analysis and Machine Intelligence2008，30，7： | 1 |
| 16 | CONDENSATION--Conditional Density Propagation for Visual Tracking 显示文摘 | Isard Michael Blake Andrew | 1998 | International Journal of Computer Vision1998，29，1： | 1 |
| 17 | CONDENSATION—Conditional Density Propagation for Visual Tracking显示文摘 | Michael Isard Andrew Blake | 1998 | International Journal of Computer Vision1998，，1： | 1 |
| 18 | Political Journalism Represented by Headline News: Canadian Public and Commercial Media Compared显示文摘 | Blake Andrew | 2013 | Canadian Journal of Political Science2013，，2： | 1 |
| 19 | A Probabilistic Exclusion Principle for Tracking Multiple Objects显示文摘 | John MacCormick Andrew Blake | 2000 | International Journal of Computer Vision2000，，1： | 1 |
| 20 | Condensation-conditional density propagation for visual tracking显示文摘 | MICHAEL ISARD ANDREW BLAKE | 1998 | International Journal of Computer Vision1998，29，1： | 1 |
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