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| 1 | Role of the complement cascade in cerebral aneurysm formation,growth,and rupture显示文摘Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑understood.Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture.In this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm pathogenesis.The studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm wall.The results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm wall.In the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies. | Blake E.S.Taylor Geoff Appelboom Robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 2 |
| 2 | Socialization Tactics, Proactive Behavior, and Newcomer Learning: Integrating Socialization Models 显示文摘 | BLAKE E ASHFORTH DAVID M SLUSS AIAN M Saks | 2007 | Journal of Voca- tional Behavior2007，70，： | 1 |
| 3 | HER-3 Overexpression Is Prognostic of Reduced Breast Cancer Survival: A Study of 4046 Patients显示文摘 | Connie G. Chiu Hamid Masoudi Samuel Leung David K. Voduc Blake Gilks David G. Huntsman Sam M. Wiseman | 2010 | Annals of Surgery2010，，6： | 1 |
| 4 | Evaluating the efficacy of statins and ACE-inhibitors in reducing gastrointestinal toxicity in patients receiving radiotherapy for pelvic malignancies显示文摘 | Linda J. Wedlake Foteini Silia Barbara Benton Amyn Lalji Karen Thomas David P. Dearnaley Peter Blake Diana Tait Vincent S. Khoo H. Jervoise N. Andreyev | 2012 | European Journal of Cancer2012，，14： | 1 |
| 5 | A two-facter model for stochastic mortality with parameter uncertainty,theory and calibration显示文摘 | David Blake Kevin Dowd | 2006 | The Journal of Risk and Insurance2006，73，4： | 1 |
| 6 | The impact of wealth on consumption and retirement behaviour in the UK显示文摘 | David Blake | 2004 | Applied Financial Economics2004，，8： | 1 |
| 7 | The development of a Clinician-Administered PTSD Scale显示文摘 | Dudley David Blake Frank W. Weathers Linda M. Nagy Danny G. Kaloupek Fred D. Gusman Dennis S. Charney Terence M. Keane | 1995 | Journal of Traumatic Stress1995，，1： | 1 |
| 8 | Cyclin D1 as a Diagnostic Immunomarker for Endometrial Stromal Sarcoma With YWHAE-FAM22 Rearrangement显示文摘 | Cheng-Han Lee Rola H. Ali Marjan Rouzbahman Adrian Marino-Enriquez Meijun Zhu Xiangqian Guo Alayne L. Brunner Sarah Chiang Samuel Leung Nataliya Nelnyk David G. Huntsman C. Blake Gilks Torsten O. Nielsen Paola Dal Cin Matt van de Rijn Esther Oliva Jonatha | 2012 | The American Journal of Surgical Pathology2012，，10： | 1 |
| 9 | YWHAE-FAM22 endometrial stromal sarcoma: diagnosis by reverse transcription–polymerase chain reaction in formalin-fixed, paraffin embedded tumor显示文摘 | Anna Isphording Rola H. Ali Julie Irving Angela Goytain Nataliya Nelnyk Lien N. Hoang C. Blake Gilks David G. Huntsman Torsten O. Nielsen Marisa R. Nucci Cheng-Han Lee | 2012 | Human Pathology2012，，： | 1 |
| 10 | Socializa- tion tactics, proactive behavior, and newcomer learning: Integra-ting socialization models 显示文摘 | Blake E Ashforth David M Sluss Alan M Saks | 2007 | Journal of Vocational Behavior2007，，70： | 1 |
| 11 | FOXL2 Is a Sensitive and Specific Marker for Sex Cord-Stromal Tumors of the Ovary显示文摘 | Osama M. Al-Agha Hassan F. Huwait Christine Chow Winnie Yang Janine Senz Steve E. Kalloger David G. Huntsman Robert H. Young C. Blake Gilks | 2011 | The American Journal of Surgical Pathology2011，，： | 1 |
| 12 | Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People显示文摘 | Diana G Redwood Elvin D Asay Ian D Blake Pamela E Sacco Claudia M Christensen Frank D Sacco James J Tiesinga Mary E Devens Steven R Alberts Douglas W Mahoney Tracy C Yab Patrick H Foote Thomas C Smyrk Ellen M Provost David A Ahlquist | 2016 | Mayo Clinic Proceedings2016，，： | 1 |
| 13 | Proposed Mekong Dam Scheme in Chi- na Threatens Millions in Downstream Countries显示文摘 | David Blake | 2001 | World Rivers Review2001，16，3： | 1 |
| 14 | 采用分析方法、毒理学和风险评估研究评估多环芳烃:以石油泄漏后海产品安全为案例显示文摘[背景]多环芳香烃(PAHs)是一种大量蔓延的环境化学物质。它们可通过自然和人为过程产生,通常存在于有机介质(包括石油)中。有几种PAHs是有毒的,其中一些还表现出致癌活性。PAHs以含有两个及以上苯环的一系列化学结构为特征,根据它们的来源,可以通过氧化、氮化和烷基化表现出多种侧链修饰。[目的]讨论当代分析方法日益增加的能力,其不仅可以分辨PAHs中不同的化学结构,而且可以识别它们在环境介质中的浓度。本文以深水地平线事故后海产品污染为例,确定由于个别PAHs的分析灵敏度增加而在PAHs风险评估过程中出现的一些问题,并描述其中许多化合物的毒理学文献缺乏的现状。[讨论]PAHs,包括种类繁多的经化学修饰或取代的PAHs,是自然产生的,如果人群暴露于有害水平就可能会遭受健康风险。然而,目前的毒性评估并没有跟上现代分析方法及其对于被替代的PAHs不断增加的检测能力。因此,尽管我们可以在海产品和其他媒介中检测这些化合物,但并没有足够的关于这些化合物的潜在毒性信息,无法将它们用于人类健康风险评估和特征描述。[结论]今后的研究工作应该尝试从战略上填补这一毒理学知识欠缺,从而更好地进行环境介质或食物中关于PAHs的人体健康风险评估。这对于石油泄漏之后的影响尤为重要。 | Jeffrey Wickliffe Edward Overton Scott Frickel Jessi Howard Mark Wilson Bridget Simon Stephen Echsner Daniel Nguyen David Gauthe Diane Blake Charles Miller Cornelis Elferink Shakeel Ansari Harshica Ferno Edward Trapido Andrew Kane 张晶 汪源 金泰廙 | 2014 | 环境与职业医学2014，31，6： | 1 |
| 15 | Creamatocrit Analysis of Human Milk Overestimates Fat and Energy Content When Compared to a Human Milk Analyzer Using Mid-infrared Spectroscopy显示文摘 | Edward F. O’Neill Paula G. Radmacher Blake Sparks David H. Adamkin | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，5： | 1 |
| 16 | MULTIPLE PARAMETER RADIATION INJURY ASSESSMENT USING A NONHUMAN PRIMATE RADIATION MODEL—BIODOSIMETRY APPLICATIONS显示文摘 | William F. Blakely Natalia I. Ossetrova Mark H. Whitnall David J. Sandgren Vadim I. Krivokrysenko Alexander Shakhov Elena Feinstein | 2010 | Health Physics2010，，2： | 1 |
| 17 | Currency value moderates equity preference among young children显示文摘 | Peter R. Blake David G. Rand | 2010 | Evolution and Human Behavior2010，，3： | 1 |
| 18 | Lead Sulfide Nanocrystal: Conducting Polymer Solar Cells 显示文摘 | Watt A A R David Blake Jamie H Warner el al | 2005 | Jounal of Physics D:Applied Physics2005，38，12： | 1 |
| 19 | Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models显示文摘 | Cheng-Han Lee Hui Xue Margaret Sutcliffe Peter W. Gout David G. Huntsman Dianne M. Miller C. Blake Gilks Y.Z. Wang | 2004 | Gynecologic Oncology2004，，1： | 1 |
| 20 | Influence of Race on Death and Ischemic Complications in Patients With Non–ST-Elevation Acute Coronary Syndromes Despite Modern, Protocol-Guided Treatment显示文摘 | Marc S. Sabatine Gavin J. Blake Mark H. Drazner David A. Morrow Benjamin M. Scirica Sabina A. Murphy Carolyn H. McCabe William S. Weintraub C Michael Gibson Christopher P. Cannon | 2005 | Circulation2005，，： | 1 |
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