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| 1 | Nano-Graphene Oxide for Cellular Imaging and Drug Delivery显示文摘Two-dimensional graphene offers interesting electronic,thermal,and mechanical properties that are currently being explored for advanced electronics,membranes,and composites.Here we synthesize and explore the biological applications of nano-graphene oxide(NGO),i.e.,single-layer graphene oxide sheets down to a few nanometers in lateral width.We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments.We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration.The NGO sheets are found to be photoluminescent in the visible and infrared regions.The intrinsic photoluminescence(PL)of NGO is used for live cell imaging in the near-infrared(NIR)with little background.We found that simple physisorption viaπ-stacking can be used for loading doxorubicin,a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro.Owing to its small size,intrinsic optical properties,large specifi c surface area,low cost,and useful non-covalent interactions with aromatic drug molecules,NGO is a promising new material for biological and medical applications. | Xiaoming Sun Zhuang Liu Kevin Welsher Joshua Tucker Robinson Andrew Goodwin Sasa Zaric Hongjie Dai | 2008 | Nano Research2008，1，3： | 118 |
| 2 | Classical epithelial-mesenchymal transition(EMT)and alternative cell death process-driven blebbishield metastaticwitch(BMW)pathways to cancer metastasis显示文摘Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards mortality.Therapies that aim to induce cell death in metastatic cells require a more detailed understanding of the metastasis for better mitigation.Towards this goal,we discuss the details of two distinct but overlapping pathways of metastasis:a classical reversible epithelial-to-mesenchymal transition(hybrid-EMT)-driven transport pathway and an alternative cell death process-driven blebbishield metastatic-witch(BMW)transport pathway involving reversible cell death process.The knowledge about the EMT and BMW pathways is important for the therapy of metastatic cancers as these pathways confer drug resistance coupled to immune evasion/suppression.We initiallydiscuss the EMT pathway and compare it with the BMW pathway in the contexts of coordinated oncogenic,metabolic,immunologic,and cell biological events that drive metastasis.In particular,we discuss how the cell death environment involving apoptosis,ferroptosis,necroptosis,and NETosis in BMW or EMT pathways recruits immune cells,fuses with it,migrates,permeabilizes vasculature,and settles at distant sites to establish metastasis.Finally,we discuss the therapeutic targets that are common to both EMT and BMW pathways. | Goodwin G.Jinesh Andrew S.Broh | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 4 |
| 3 | Performance of broilers in cages显示文摘 | Andrews L D Goodwin T L | 1973 | Poult Sci1973，52，： | 1 |
| 4 | Passing on tacit knowledge in anaesthesia : a qualitative study 显示文摘 | CATHERINE POPE ANDREW SMITH DAWN GOODWIN MAG- GIE MORT | 2003 | Medical Education2003，，37： | 1 |
| 5 | Performance of broilers in cages显示文摘 | Andrews L D Goodwin T L | 1973 | Poult Sci1973，52，： | 1 |
| 6 | Performance of broilers in cages显示文摘 | Andrews L D Goodwin T L | 1973 | Poult Sci1973，52，： | 1 |
| 7 | Performance of broilers in cages 显示文摘 | Andrews L D Goodwin T L | 1973 | Poult Sci1973，52，： | 1 |
| 8 | Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes显示文摘 | Denis Azzopardi Brenda Strohm Neil Marlow Peter Brocklehurst Aniko Deierl Oya Eddama Julia Goodwin Henry L. Halliday Edmund Juszczak Olga Kapellou Malcolm Levene Louise Linsell Omar Omar Marianne Thoresen Nora Tusor Andrew Whitelaw A. David Edwards | 2014 | The New England Journal of Medicine2014，，： | 1 |
| 9 | C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma显示文摘SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts. | Goodwin G.Jinesh Marian T.Smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao Michelle A.Reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Brohl | 2024 | Genes & Diseases2024，11，1： | 0 |
| 10 | 《SHOCK》2019年第3期新观点显示文摘2019年3月期的《休克》杂志将临床和基础科学研究有力结合,填补了创伤、脓毒症和炎症领域的重要知识空白。该期共16篇文章,重点讨论凝血疾病、输血、生物标志物、内皮功能、巨噬细胞极化和细胞治疗。这些文章的作者们给大家带来了精彩的研究成果。纤维蛋白溶解关闭是创伤死亡率增加的一个独立危险因素。第一篇文章来自务实优秀的最优血小板和血浆比率(PROPPR)研究小组,是一篇关于创伤后血栓弹力图(TEG)纤维蛋白溶解关闭的继发性研究。 | Hongkuan Fan Andrew J. Goodwin 朱浙祥(译) | 2019 | 实用休克杂志(中英文)2019，3，2： | 0 |
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