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| 1 | Endoscopic ultrasound sedation in the United Kingdom: Is life without propofol tolerable?显示文摘There is compelling evidence to support the quality,cost effectiveness and safety profile of non-anesthesiologist-administered propofol for endoscopic ultrasound (EUS). However in the United Kingdom, it is recommended that the administration and monitoring of propofol sedation for endoscopic procedures should be the responsibility of a dedicated and appropriately trained anaesthetist only. The majority of United Kingdom EUS procedures are performed with opiate and benzodiazepine sedation rather than anaesthetist led propofol lists due to anaesthetist resource availability. We sought to prospectively determine the tolerability and safety of EUS with benzodiazepine and opiate sedation in single United Kingdom centre. Two hundred consecutive patients undergoing either EUS or oesophago-gastroduodenoscopy (OGD) with conscious sedation were prospectively recruited with a 1:1 enrolment ratio. Patients completed questionnaires pre and post procedure detailing anticipated and actual pain experienced on a 1-10 visual analogue scale. Demographics, procedure duration, sedation doses and willingness to repeat the procedure were also recorded. EUS procedures lasted significantly longer than OGDs(15 min vs 6 min, P < 0.0001), however, there was no difference in anticipated pain scores between the groups(EUS 3.37/10 vs OGD 3.47/10, P = 0.46). Pain scores indicated EUS was better tolerated than OGD(1.16/10 vs 1.88/10, P = 0.03) although higher doses of sedation were used for EUS procedures. There were no complications identified in either group. We feel our study demonstrates that the tolerability of EUS with opiate and benzodiazepine sedation is acceptable. | Jennifer Anne Campbell Andrew James Irvine Andrew Derek Hopper | 2017 | World Journal of Gastroenterology2017，23，3： | 2 |
| 2 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 4 | Colny-stimulating factor-1(CSF-1) delivers a proatherogenic signal to human macrophages显示文摘 | Irvine KM Andrews MR Fernande-Roio MA | 2009 | J Leukoc Biol2009，85，2： | 1 |
| 5 | Water sources accessed by arid zone riparian trees in highly saline environments, Australia显示文摘 | Justin F. Costelloe Emily Payne Ian E. Woodrow Elizabeth C. Irvine Andrew W. Western Fred W. Leaney | 2008 | Oecologia2008，，1： | 1 |
| 6 | Synthesis of multifunctional hydroxyethyl tetrazoles 显示文摘 | Andrew Chafin David J Irvin Mark H Mason | 2008 | Tetrahedron Letters2008，49，： | 1 |
| 7 | A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries 显示文摘 | Andrews KL Irvine JC Tare M | 2009 | Br J Pharmacol2009，157，： | 1 |
| 8 | 森林 郑州中心显示文摘中原地区是华夏文明的摇篮。6世纪末,位于此地的郑州古城逐渐成为重要城市之一。如今的郑州快速崛起,成为河南省的政治与经济中心,不懈地试图在未来图景中重塑昔日形象。由如恩设计的郑州中心大楼位于城市一处待开发区域。在这座城市中,文化遗产与现代化发展之间充斥着各样的矛盾。郑州的历史古迹,如城墙和要塞塔楼,其建造形式和材料与这片土地密切相关。而如今的郑州规划了新的城市中心,并用大片的玻璃塔楼群向天空示意,轻盈透亮并自带反射的外观仿佛在骄傲地宣告它们作为现代性标志的存在。随着郑州开始对全新身份的追寻. | 郭锡恩 胡如珊 张堇盈 王典 唐晓棠 宋和贞 Andrew Irvin 贾城 杨秉鑫 杨佩琛 Malgorzata Mutkowska Bemanlo Taliani 李秋橙 Lara de Pedro 陈相宇 马瑞君 陈洋扬 苏禹竹 张妍 顾嘉诚 Erin Chen Lisa Chen 杨新越 谢博宇 周原仰 郑丽丽 辛海鸥 洪明月 | 2023 | 城市环境设计2023，，2： | 0 |
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