|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 3 | An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression显示文摘 | Jerome Barbier Xin Chen Gabriel Sanchez Muyan Cai Marion Helsmoortel Takuma Higuchi Pierre Giraud Xavier Contreras Gangjun Yuan Zihao Feng Rima Nait-Saidi Olivier Deas Lisa Bluy Jean-Gabriel Judde Sylvie Rouquier William Ritchie Shuji Sakamoto Dan Xie Rosemary Kiernan | 2018 | Cell Research2018，28，5： | 3 |
| 4 | Biomarkers for colitis-associated colorectal cancer显示文摘Patients with extensive ulcerative colitis(UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. Using a wide range of molecular techniques- including cutting-edge OMICS technologies- recent studies have identified clinically relevant biomarker candidates from a variety of biosamples, including colonic biopsies, blood, stool, and urine. While the challenge remains to validate these candidate biomarkers in multi-center studies and with larger patient cohorts, it is certain that accurate biomarkers of colitis-associated neoplasia would improve clinical management of neoplastic risk in UC patients. This review highlights the ongoing avenues of research in biomarker development for colitis-associated colorectal cancer. | Ru Chen Lisa A Lai Teresa A Brentnall Sheng Pan | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 5 | A phase II trial of second‐line axitinib following prior antiangiogenic therapy in advanced hepatocellular carcinoma显示文摘 | Mairéad G. McNamara Lisa W. Le Anne M. Horgan Alex Aspinall Kelly W. Burak Neesha Dhani Eric Chen Mehrdad Sinaei Glen Lo Tae Kyoung Kim Patrik Rogalla Oliver F. Bathe Jennifer J. Knox | 2015 | Cancer2015，，10： | 2 |
| 6 | Immortalized mouse dental papilla mesenchymal cells preserve odontoblastic phenotype and respond to bone morphogenetic protein 2显示文摘 | Feng Wang Li-An Wu Wentong Li Yuan Yang Feng Guo Qingping Gao Hui-Hsiu Chuang Lisa Shoff Wei Wang Shuo Chen | 2013 | In Vitro Cellular & Developmental Biology - Animal2013，，： | 1 |
| 7 | Association of Aspirin Dose and Vorapaxar Safety and Efficacy in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome (From the TRACER Trial)显示文摘 | Kenneth W. Mahaffey Zhen Huang Lars Wallentin Robert F. Storey Lisa K. Jennings Pierluigi Tricoci Harvey D. White Paul W. Armstrong Philip E. Aylward David J. Moliterno Frans Van de Werf Edmond Chen Sergio Leonardi Tyrus Rorick Claes Held John Strony Robe | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 8 | The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotrophin activity in pregnant macaques显示文摘 | Chen J G Lisa S L Andrew G | 2003 | Toxicology2003，186，12： | 1 |
| 9 | Design of a nonlinear disturbance observer 显示文摘 | LISA Pathfinder drag-free control Classical and Quantum Gravity Chen X K Komada S Fukuda T | 2000 | IEEE Transactions on Industrial Electronics2000，47，2： | 1 |
| 10 | Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients显示文摘 | Zhenwu Lin John P. Hegarty Wei Yu Jon A. Cappel Xi Chen Pieter W. Faber Yunhua Wang Lisa S. Poritz Jian-Bing Fan Walter A. Koltun | 2012 | Digestive Diseases and Sciences2012，，： | 1 |
| 11 | The role of stem cells in the treatment of diabetic foot ulcers显示文摘 | Sheila N. Blumberg Alexandra Berger Lisa Hwang Irena Pastar Stephen M. Warren Weiliam Chen | 2011 | Diabetes Research and Clinical Practice2011，，1： | 1 |
| 12 | Efficacy and Safety of Metronidazole for Pulmonary Multidrug-Resistant Tuberculosis显示文摘 | Matthew W. Carroll Doosoo Jeon James M. Mountz Jong Doo Lee Yeon Joo Jeong Nadeem Zia Myungsun Lee Jongseok Lee Laura E. Via Soyoung Lee Seok-Yong Eum Sung-Joong Lee Lisa C. Goldfeder Ying Cai Boyoung Jin Youngran Kim Taegwon Oh Ray Y. Chen Lori E. Dodd W | 2013 | Antimicrobial Agents and Chemotherapy2013，，8： | 1 |
| 13 | A novel fast image encryption scheme based on 3D chaotic baker maps 显示文摘 | Mao Y B Chen G R Lisa S G | 2004 | lnternational Journal of Bifurcation and Chaos2004，14，10： | 1 |
| 14 | Prevalence of Germline PTEN, BMPR1A, SMAD4, STK11, and ENG Mutations in Patients With Moderate-Load Colorectal Polyps显示文摘 | Joanne Ngeow Brandie Heald Lisa A. Rybicki Mohammed S. Orloff Jin Lian Chen Xiuli Liu Lisa Yerian Joseph Willis Heli J. Lehtonen Rainer Lehtonen Jessica L. Mester Jessica Moline Carol A. Burke James Church Lauri A. Aaltonen Charis Eng | 2013 | Gastroenterology2013，，7： | 1 |
| 15 | Optimizing partners’ choice in IS/IT outsourcing projects: The strategic decision of fuzzy VIKOR显示文摘 | Lisa Y. Chen Tien-Chin Wang | 2008 | International Journal of Production Economics2008，，1： | 1 |
| 16 | Optimizing partners' choice in IS/IT outsourcing projects: The strategic decision of fuzzy VIKOR显示文摘 | Lisa Y Chen Tien-Chin Wang | 2009 | Int J Production Economics2009，120，9： | 1 |
| 17 | Efficacy and Safety of Hyaluronan Treatment in Combination Therapy With Home Exercise for Knee Osteoarthritis Pain显示文摘 | Todd P. Stitik Marcia F. Blacksin Doreen M. Stiskal Jong H. Kim Patrick M. Foye Lisa Schoenherr Eun-Seok Choi Boqing Chen Howard J. Saunders Scott F. Nadler | 2007 | Archives of Physical Medicine and Rehabilitation2007，，： | 1 |
| 18 | Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1显示文摘 | Wei Yu Zhenwu Lin John Hegarty Xi Chen Ashley Kelly Yunhua Wang Lisa Poritz Walter Koltun | 2012 | Inflammation2012，，3： | 1 |
| 19 | 显示文摘 | Lisa P Chen | 1998 | Macromolecules1998，31，16： | 1 |
| 20 | Live virus vaccines based on a yellow fever vaccine backbone: Standardized template with key considerations for a risk/benefit assessment显示文摘 | Thomas P. Monath Stephen J. Seligman James S. Robertson Bruno Guy Edward B. Hayes Richard C. Condit Jean Louis Excler Lisa Marie Mac Baevin Carbery Robert T. Chen | 2014 | Vaccine2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员