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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 3 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 4 | Detrital sedimentary rock classification and nomenclature for use in new zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，： | 1 |
| 5 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | olk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 6 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | | 0，，04： | 1 |
| 7 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 8 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 9 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 10 | Treatment of experimental pancreatic cancer by doxorubicin-, mitoxantrone-, and irinotecan-drug eluting beads显示文摘 | Vugar Yagublu Natavan Caliskan Andrew L. Lewis Ralf Jesenofsky Lala Gasimova J. -Matthias L?hr Michael Keese | 2013 | Pancreatology2013，，1： | 1 |
| 11 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | FOLK R L ANDREWS P B LEWIS D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 12 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | FOLK R L ANDREWS P B LEWIS D W | 1970 | Journal of Geology and Geophysiea1970，13，： | 1 |
| 13 | Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes显示文摘 | Rubio-Cabezas Oscar Minton Jayne A L Caswell Richard Shield Julian P Deiss Dorothee Sumnik Zdenek Cayssials Amely Herr Mathias Loew Anja Lewis Vaughan Ellard Sian Hattersley Andrew T | 2009 | Diabetes Care2009，，1： | 1 |
| 14 | Detrital sedimen- tary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 15 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 16 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | FOLK R L ANDREWS P B LEWIS D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，： | 1 |
| 17 | Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin显示文摘 | Ergül Eyol Annemarie Boleij Rachel R. Taylor Andrew L. Lewis Martin R. Berger | 2008 | Clinical & Experimental Metastasis2008，，3： | 1 |
| 18 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 19 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | | 0，，： | 1 |
| 20 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，： | 1 |
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