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| 1 | Acupuncture-moxibustion in treating irritable bowel syndrome: How does it work?显示文摘Irritable bowel syndrome(IBS)is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits.It has drawn great attention because of its high prevalence,reoccurring symptoms,and severe influence on patients’lives.Many clinical studies have demonstrated the efficacy of acupuncturemoxibustion in treating IBS.Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS,and the adoption of modern techniques has achieved some progress.This article reviews the latest advances among actionmechanism studies from the perspectives of gastrointestinal motility,visceral hypersensitivity,the braingut axis,the neuroendocrine system,and the immune system.It is shown that acupuncture-moxibustion can effectively regulate the above items,and thus,this treatment should have a high efficacy in the treatment of IBS.This article also identifies existing problems in current mechanism research and raises several ideas for future studies.Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS. | Xiao-Peng Ma Jue Hong Cai-Ping An Dan Zhang Yan Huang Huan-Gan Wu Cui-Hong Zhang Sian Meeuwsen | 2014 | World Journal of Gastroenterology2014，20，20： | 30 |
| 2 | Endothelial progenitor cells in cardiovascular diseases显示文摘Endothelial dysfunction has been associated with the development of atherosclerosis and cardiovascular diseases. Adult endothelial progenitor cells(EPCs) are derived from hematopoietic stem cells and are capable of forming new blood vessels through a process of vas-culogenesis. There are studies which report correlations between circulating EPCs and cardiovascular risk fac-tors. There are also studies on how pharmacotherapies may influence levels of circulating EPCs. In this review, we discuss the potential role of endothelial progenitor cells as both diagnostic and prognostic biomarkers. In addition, we look at the interaction between cardio-vascular pharmacotherapies and endothelial progenitor cells. We also discuss how EPCs can be used directly and indirectly as a therapeutic agent. Finally, we evalu-ate the challenges facing EPC research and how these may be overcome. | Poay Sian Sabrina Lee Kian Keong Poh | 2014 | World Journal of Stem Cells2014，6，3： | 22 |
| 3 | 潮汕地区农村中学生自行车伤害与相关因素的研究显示文摘目的探讨潮汕农村地区中学生自行车伤害的流行病学特征及其相关因素之间的关系,为进一步进行干预研究提供基础资料。方法采用分层整群抽样方法和自填式问卷调查,对该地区6个学校3544名中学生进行自行车伤害发生情况、骑乘自行车时的危险行为、学生及其家庭基本情况等进行调查。结果潮汕地区农村中学自行车伤害发生率为11.0%,男生高于女生,15岁中学生高于其他年龄组中学生;不同年级、性别、是否住宿和不同学校的中学生自行车伤害发生率差异均有统计学意义。84.6%的中学生上学的主要交通工具是自行车;选择不同交通方式上下学的中学生因自行车导致的伤害发生率有差异。有乘骑自行车危险行为者易发生自行车伤害(P<0.01),其中单手离把撑伞和骑车带人的行为最多,分别为1600人(69.7%)和973人(42.4%)。结论潮汕农村中学生骑乘自行车上学普遍,自行车伤害发生率高,与性别、年龄和家庭经济有关;在骑乘自行车时存在较多危险行为,提示预防和降低儿童青少年交通伤害的发生应采取针对性的措施。 | 叶燕如 李丽萍 卢耀贵 高杨 Sian Griffiths | 2009 | 中华疾病控制杂志2009，13，5： | 6 |
| 4 | 农村地区中学生自行车伤害危险因素病例对照研究显示文摘目的探讨农村地区中学生自行车伤害发生的危险因素,为农村地区中学生自行车伤害的预防控制工作提供科学依据。方法采用分层整群抽样方法,应用自填式问卷调查方式,对潮汕两英镇地区6所中学的3 708名中学生的自行车伤害发生情况进行调查。对筛选出的502例伤害病例,根据同学校、同年级、同性别的原则,在骑乘自行车上下学而未发生自行车伤害的学生中,按照1∶3匹配,采用病例对照研究方法进行相关因素的Logistic回归分析。结果骑车者搭扶其他车辆(OR=1.603,95%CI=1.174~2.189)、骑车者骑车带人(OR=1.395,95%CI=1.119~1.746)、乘坐自行车时搭扶其他车辆(OR=1.776,95%CI=1.356~2.327)、乘坐自行车时与骑车者打闹(OR=1.594,95%CI=1.202~2.117)、父亲在外工作或经商(OR=1.500,95%CI=1.194~1.885)、家庭人均年收入低于5 000元(OR=3.320,95%CI=1.979~5.570)为农村地区中学生自行车伤害发生的危险因素。而家庭人均年收入高于5 000元(OR=0.257,95%CI=0.076~0.719)为保护因素。结论中学生自身不良的骑车行为、父亲在外和家庭经济水平低是影响农村地区中学生自行车伤害的危险因素。 | 冀艳虎 李丽萍 卢耀贵 张铭志 高杨 Griffiths Sian | 2012 | 中华疾病控制杂志2012，16，2： | 6 |
| 5 | The genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume显示文摘Medicago polymorpha is a nutritious and palatable forage and vegetable plant that also fixes nitrogen.Here,we reveal the chromosome-scale genome sequence of M.polymorpha using an integrated approach including Illumina,PacBio and Hi-C technologies.We combined PacBio full-length RNA-seq,metabolomic analysis,structural anatomy analysis and related physiological indexes to elucidate the important agronomic traits of M.polymorpha for forage and vegetable usage.The assembled M.polymorpha genome consisted of 457.53Mb with a long scaffold N50 of 57.72Mb,and 92.92%(441.83Mb)of the assembly was assigned to seven pseudochromosomes.Comparative genomic analysis revealed that expansion and contraction of the photosynthesis and lignin biosynthetic gene families,respectively,led to enhancement of nutritious compounds and reduced lignin biosynthesis in M.polymorpha.In addition,we found that several positively selected nitrogen metabolism-related genes were responsible for crude protein biosynthesis.Notably,the metabolomic results revealed that a large number of flavonoids,vitamins,alkaloids,and terpenoids were enriched in M.polymorpha.These results imply that the decreased lignin content but relatively high nutrient content of M.polymorpha enhance its edibility and nutritional value as a forage and vegetable.Our genomic data provide a genetic basis that will accelerate functional genomic and breeding research on M.polymorpha as well as other Medicago and legume plants. | Jiawen Cui Zhaogeng Lu Tianyi Wang Gang Chen Salma Mostafa Hailong Ren Sian Liu Chunxiang Fu Li Wang Yingfang Zhu Jinkai Lu Xiang Chen Zhenwu Wei Biao Jin | 2021 | Horticulture Research2021，8，1： | 6 |
| 6 | 社区多重慢病与健康管理显示文摘环境、人口、及经济转型带来的慢性非传染性疾病已经成为许多国家的头号健康威胁。多重病的患病率近年来稳步上升,与年龄增长密切相关,同时也与医疗服务因素及生活方式相关。多重慢病患者有更大的卫生保健需求。国际经验已经表明了初级卫生保健的巨大作用。加强初级保健下的社区健康管理可以带来更适宜、更有成效及更低成本的护理。面对来自于慢性疾病及多重病的新兴公共卫生问题,更需要加强多学科医疗保健服务模式下的社区健康管理。 | 王皓翔 王家骥 黄仰山 黄至生 Sian M GRIFFITHS Stewart W MERCER | 2015 | 医师在线2015，1，1： | 5 |
| 7 | Elderly healthcare service at the community health centers in the Pearl River Delta region,China显示文摘Objective:The recent population census showed China had officially become a graying society.In the meantime,China also faces a growing burden of non-communicable diseases.Since 2009,a series of policies have been implemented to enhance primary care at the community level.This study describes the elderly care services provided in the differently organized community health centers(CHCs).Methods:It covered 13 CHCs of six cities located within the Pearl River Delta(PRD)region.In-depth interviews were conducted with a total of 59 health administrators,CHC managers,and CHC doctors regarding elderly care.Results:The study found that accessibility of healthcare for elders has been improved due to the development of health insurance schemes as well as preferential policy to encourage the CHC utilization by the elderly.All the CHCs provide health examinations and chronic disease management to the permanent elderly within their catchment district.However,some preventative care such as fall prevention,immunization and mental health management are not provided.Conclusion:Key barriers include low capacity of health service providers in the CHCs,and a lack of government investment in CHCs.Our report provides an empirical evidence for the health care reform in China. | NAN YANG XIAOLIN WEI HAITAO LI ZHENZHEN ZHANG JAMIE RODAS SAMUEL YS WONG MARTIN CS WONG YANG GAO JIAJI WANG DONALD KT LI JINLING TANG SIAN GRIFFITHS | 2013 | Family Medicine and Community Health2013，1，1： | 5 |
| 8 | Comparison of reflux esophagitis and its complications between African Americans and non-Hispanic whites显示文摘AIM: To determine the effect of ethnicity on the severity of reflux esophagitis (RE) and its complications. METHODS: A retrospective search of the endoscopy database at the University of Florida Health Science Center/Jacksonville for all cases of reflux esophagitis and its complications from January 1 to March 31, 2001 was performed. Inclusion criteria were endoscopic evidence of esophagitis using the LA classif ication, reflux related complications and self-reported ethnicity. The data obtained included esophagitis grade, presence of a hiatal hernia, esophageal ulcer, stricture and Barrett's esophagus, and endoscopy indication. RESULTS: The search identified 259 patients with RE or its complications, of which 171 were non-Hispanic whites and 88 were African Americans. The mean ages and male/female ratios were similar in the two groups. RE grade, esophageal ulcer, stricture and hiatal hernia frequency were likewise similar in the groups. Barrett's esophagus was present more often in non-Hispanic whites than in African Americans (15.8% vs 4.5%; P < 0.01). Heartburn was a more frequent indication for endoscopy in non-Hispanic whites with erosive esophagitis than in African Americans (28.1% vs 7.9%; P < 0.001). CONCLUSION: Distribution of RE grade and frequency of reflux-related esophageal ulcer, stricture andhiatal hernia are similar in non-Hispanic whites and African Americans. Heartburn was more frequently and nausea/vomiting less frequently reported as the primary endoscopic indication in non-Hispanic whites compared with African Americans with erosive esophagitis or its complications. African Americans have a decreased prevalence of Barrett's esophagus compared with non-Hispanic whites. | Kenneth J Vega Sian Chisholm M Mazen Jamal | 2009 | World Journal of Gastroenterology2009，15，23： | 4 |
| 9 | 农村儿童自行车道路交通伤害发生原因的定性研究显示文摘目的 探讨农村地区儿童自行车伤害发生的原因及其相关人群的态度.方法 采用焦点小组访谈的定性研究方法,围绕自行车伤害发生的原因及态度等问题,对广东省两地区农村103名调查对象共14个专题小组进行访谈.研究人员经过统一培训,调查对象包括学生、家长和教师三类人群.对访谈的全部内容进行录音,并应用QSR NVivo 8.0软件对访谈内容进行辅助分析.结果 访谈对象认为不遵守交通规则、骑车不专心和车速太快是导致儿童发生自行车伤害的主要原因;相对重要性分别为1.00、0.80和0.78.学生、家长及教师三组人群均从主观及客观原因两方面分析了儿童发生自行车伤害的原因,但不同人群对伤害发生的各种原因存在不同的观点,三组人群中认为骑车速度快(在学生组访谈中出现14频次,家长组8频次)和不遵守交通规则(教师组出现14频次)为主观原因;而路况差是客观原因(出现23频次).结论 广东省两地区农村不同人群对儿童自行车伤害的认识普遍不高,应加强农村儿童道路伤害预防的健康教育,提高农民的道路安全意识. | 叶燕如 李丽萍 卢耀贵 张铭志 高杨 Griffiths Sian | 2010 | 中华流行病学杂志2010，31，10： | 3 |
| 10 | Gap between evidence and physicians' knowledge and practice regarding hypertension and its drug treatment: a survey in a Chinese city显示文摘背景基于证据的药进入了它的秒十年。怎么准备了临床医生,在特别地在开发乡村遗体练习它不清楚。因此,我们在中国在城市的医院里进行了医生的这调查在 China.Methods 为心血管的疾病的主要预防关于 antihypertensive 药决定在研究证据和医生的知识和实践之间的差距的尺寸由面对面会见的生气部分调查在中国在 20 所第三级的综合医院被进行在 2005 。 444 位医生的一个总数(主要心脏病专家)在内部药,在过去的 12 个月内对待至少一个高血压的病人的人,在他们高血压的心血管的风险的感觉上为会见被邀请, antihypertensive 药的利益的大小,全面风险途径上的知识,使用的首要的药,药治疗在上面被推荐的风险,和 468 位合格医生中的 444 个全部的基于证据的 medicine.Results A 上的知识是 suc 他们估计有 8.4% 的实际 5 年的心血管的风险的一个高血压的人将有 40% 的 5 年的心血管的风险(95% CI:38% ~ 42%) 如果没对待,并且在 20% 从药治疗有绝对风险减小和相对风险减小(95% CI。18% ~ 22%) 并且 39%(95% CI:37% ~ 42%) 分别地,作为与 3.3% 相比并且在研究证据显示出的 33%respectively。平均,医生将在需要到 368 的对待(NNT ) 的一个数字推荐药治疗或更小,作为与为用普通高血压的中国人的药治疗的 50 的实际 NNT 相比。百分之 55 (95% CI:50% ~ 59%) 从未专心地他们使用了国家高血压指南。多数仍然由忽略另外的风险因素或全面风险独自首先基于血压开了药并且 78%(95 %C/ 。76% ~ 83%) 使用象钙隧道 blockers 和血管收缩素变换酶(王牌) 那样的新昂贵的药禁止者同样首要的处理。(到 18% 的 95%CI:9%) 仅仅, 13% 能正确地解释 NNT。百分之 43 (95% CI:39% ~ 48%) 不知道使随机化的控制审判是科学地在为评估反高血压的 drugs.Ninety 的有效性的另外的学习图案之中最严密 -- 百分之二(95% CI:90% ~ 94%) 当与审判对比为证据看待反高血压的药的有效性时,不知道他们能由寻找系统的评论开始。百分之 96 (95% CI:94% ~ 98%) 不知道 Cochrane 图书馆是调查医生显著地过高估计的系统的 reviews.Conclusions 的重要来源高血压的心血管的风险和药治疗的利益来临。他们在比为西方的人口建议的截止甚至低的心血管的风险推荐了药处理,它将使许多成为为药处理合格的更多的人。尽管更旧的更便宜的可能在许多病人是更适当的,他们也趋于开新昂贵的药。他们在基于证据的药的基础上显示出不恰当的知识。 | WANG Wei-zhong TANG Jin-ling HU Yong-hua AN Jian-gang WANG Yan-ling REN Zho-he ZHANG Hong Sian Griffiths | 2011 | Chinese Medical Journal2011，，8： | 3 |
| 11 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 12 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 13 | ApoEε4等位基因与阿尔茨海默氏病的关系显示文摘从分子遗传学和分子生物学角度述评了载脂蛋白Eε4 (ApoEε4 )等位基因与阿尔茨海默氏病(AD)及相关疾病关系的研究成果。指出ApoEε4是AD的危险因素之一 ,ApoEε4阳性个体比阴性个体患晚发AD的危险性约高 3倍 ,但ApoEε4远不是AD的诊断指标或预测标志。在具有记忆损害的老人中 ,ApoEε4至少可确认为是痴呆的一种因素。ApoEε2可能是区别Lewybody病和晚发AD的遗传因素之一。ApoEε4和脑血管病对血管性痴呆 (VD)可能具有协同作用。 | 田金洲 杨承芝 袁致祥 Judy Haworth Sian MacGowan Gordon Wilcock | 1999 | 北京中医药大学学报1999，22，5： | 2 |
| 14 | NETNEP SPECIAL ISSUE ‘Changing the landscape for nursing and healthcare education: Evidence-based innovation, policy and practice’显示文摘 | Sian E. Maslin-Prothero | 2013 | Nurse Education Today2013，，7： | 1 |
| 15 | Water reuse at the UK’s Millennium Dome显示文摘 | Alan Smith Ju Khow Sian Hills | 2000 | 2000 (118)2000，，118： | 1 |
| 16 | Functional characterization of The spontaneously transformed human umbilical vein endothelial cell line ECV304: use in an in vitro model of angiogenesis显示文摘 | SIAN E Hughes | 1996 | Experimental cell Research1996，225，1： | 1 |
| 17 | ACE gene polymorphism as a prognostic indicator in patients with Type 2 diabetes and established renal disease显示文摘 | Fava Stephen Ellard Sian Azzopardi Joseph | 2001 | Diabetes Care2001，24，12： | 1 |
| 18 | Can Primary School Contribute Effectively to Tier I Child Mental Health Services显示文摘 | Gowers Simon Thomas Sian Deeley Sarah | 2004 | Clinical Child Psychology & Psychiatry2004，9，3： | 1 |
| 19 | The case for induced pluripotent stem cell‐derived cardiomyocytes in pharmacological screening显示文摘 | Jaffar M Khan Alexander R Lyon Sian E Harding | 2013 | British Journal of Pharmacology2013，，2： | 1 |
| 20 | Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia显示文摘 | SIAN J DEXTER D T LEES A J | 1994 | Ann Neurol1994，36，3： | 1 |
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