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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Divergent Immunomodulatory Effects of Extracts and Phenolic Compounds from the Fern Osmunda Japonica Thunb显示文摘目的将学习 Osmunda 装饰用的梨树 Thunb 的可能的 immunobiological 潜力。从 O 的根茎准备的乙醇摘录的方法 Immunomodulatory 效果。从摘录孤立的装饰用的梨树和酉分的混合物被调查在下面在里面用老鼠腹房间的 vitro 条件(2 污祬愠潬杮眠瑩 ? 牰来慮据 ? 瀠潲牧獥楳杮映潲 ? 牰来慮瑮搠祡? 摐 ? | 朱晓新 李玉洁 杨岚 张东 陈颖 Eva Kmonickova 翁小刚 杨庆 Zdenek Zidek | 2013 | Chinese Journal of Integrative Medicine2013，19，10： | 9 |
| 3 | 云母的命名显示文摘定义云母为层状硅酸盐。其结构单元由两个相向排列的四面体片(Ts)和夹于其间的一个八面体片(Os)组成。这些片构成一个单元层,层与层之间被非水化层间阳离子(I)分开,其顺序是:非水化阳离子层、四面体片、八面体片、四面体片、非水化阳离子层、四面体片、八面... | Milan Rieder,Giancarlo Cavazzini,Yurii S.D’yakonov, Viktor A.Frank Kamenetskii,Glauco Gottardi,Stephen Guggenheim,Pavel V.Koval′, Georg Muller,Ana M.R.Neiva,Edward W.Radoslovich,Jean Louis Robert, Francesco P.Sassi,Hiroshi Takeda,Zdenek Weiss,Davi | 1999 | 矿物岩石地球化学通报1999，18，3： | 8 |
| 4 | Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis显示文摘Helicobacter pylori(H.pylori)is an infectious agent influencing as much as 50%of the world’s population.It is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with H.pylori infection.These include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s disease.There is also evidence for a relationship between H.pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma.Generally little is known about the relationship between H.pylori infection and diseases of the pancreas.Most evidence about H.pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis.There is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in H.pylori-positive patients.The pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been proposed.Reduction of antral Dcells in H.pylori-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin secretion.That stimulates pancreatic growth and thus increases the risk of carcinogenesis.Alternatively,H.pylori,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation.The role of H.pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of H.pylori and pancreatic tissue.Patients with autoimmune pancreatitis often show positivity for antibodies against H.pylori proteins.H.pylori,as a part of microbiome dysbiosis,also is viewed as a potential trigger of autoimmune inflammation of the pancreas.It is precisely these relationships(and associated equivocal conclusions)that constitute a center of attention among pancreatologists,immunologists and pathologists.In order to obtain clear and valid results,more studies on sufficiently large cohorts of patients are needed.The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research.Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. | Lumir Kunovsky Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 5 |
| 5 | Effect of CaO on retention of S, Cl, Br, As, Mn, V, Cr, Ni, Cu, Zn,W and Pb in bottom ashes from fluidized-bed coal combustion power station显示文摘This work was conducted to evaluate whether Ca-bearing additives used during coal combustion can also help with the retention of some other elements. This work was focused on the evaluation of bottom ashes collected during four full-scale combustion tests at an operating thermal fluidized-bed power station. Bottom ashes were preferred to fly ashes for the study to avoid interference from condensation processes usually occurring in the post-combustion zone. This work focused on the behaviors of S, Cl, Br, As, Mn, V, Cr, Ni, Cu,Zn, W, and Pb. Strong positive correlations with CaO content in bottom ashes were observed(for all four combustion tests) for S, As, Cl and Br(R = 0.917–0.999). Strong inverse proportionality was calculated between the contents of Pb, Zn, Ni, Cr and Mn and CaO, so these elements showed association to materials other than Ca-bearing compounds(e.g., to aluminosilicates, organic matter, etc.). Somewhat unclear behaviors were observed for W, Cu, and V. Their correlation coefficients were evaluated as statistically 'not significant', i.e., these elements were not thought to be significantly associated with CaO. It was also discovered that major enrichment of CaO in the finest bottom ash fractions could be advantageously used for simple separation of elements strongly associated with these fractions, mainly S and As, but also Cl or Br. Removal of5% of the finest ash particles brings about a decrease in As concentration down to 77%–80% of its original bulk ash content, which can be conveniently used e.g., when high As content complicates further ash utilization. | Lucie Bartonova Zdenek Klika | 2014 | Journal of Environmental Sciences2014，26，7： | 5 |
| 6 | Antibodies Against Annexin V and Prothrombin,Their Correlation with Other Anti-phospholipid Antibodies in Recurrent Pregnancy Loss显示文摘Objective To study the findings of serum antibodies against annexin V, prothrombin,ph-inositol, ph-acid, ph-ethanolamine, ph-serine, ph-glycerol, cardiolipin, and beta2-glycoprotein I and analyze the trophoblast annexin V receptorsMethods Sera from 156 patients aged 26-41 years with recurrent pregnancy loss (3-7 times) were investigated. Eighty-four fertile healthy women aged 24-38 yearswere included in a control group. ELISA methods were used for detecting a panel of seraanti-phospholipid antibodies. Immunolocalization of annexin V receptors in 143trophoblast specimens of 156 patients was investigated by the immunofluorescencetechnique using Annexin V-FITC, Apoptosis and AnnexinV-CY3 commercial kits.Results Positivity for anti-phospholipid antibodies mainly against ph-serine, ph-ethanolamine, and ph-inositol was found together in 80.8% (126 out of 156 patients),anti-prothrombin antibodies in 12% (18), and anti-annexin V antibodies in 13. 5%(21) women. No significant levels of anti-phospholipid antibodies were found in 6controls. Placenta immunohistopathology also exhibited some changes manifested bythe presence of apoptotic and necrotic cells in trophoblast, and very fewmicrothrombotization in some intervillous spaces.Conclusion Our detailed study demonstrated the prevalence of majority of anti-phospholipid antibodies as a high risk factor for repeated reproductive failure. Verylow microthrombosis in placentas could be explained by the changes ofhaemocoagulation properties out of uterus. | Zdenka Ulcova-Gallova Petr Mukensnabl Sarka Hadravska Vendula Kyselova Jitka Slechtova Zdenka Micanova Katerina Bibkova Miroslav Balvin Zdenek Rokyta | 2005 | Journal of Reproduction and Contraception2005，16，1： | 3 |
| 7 | Competitive hydrogenation in binary diene systems on a palladium catalyst 显示文摘 | Jiri K P Zdenek S Josef P | 2006 | React Kinet Catal Lett2006，89，2： | 1 |
| 8 | Expression of class III β-tubulin in normal and neoplastic human tissues显示文摘 | E. Dráberová Zdenek Lukás Dagmar Ivanyi Vladimír Viklicky Pavel Dráber | 1998 | Histochemistry and Cell Biology1998，，3： | 1 |
| 9 | On a closure concept in clawfree graphs 显示文摘 | Zdenek Ryjacek | 1997 | J C ombin Theory Ser B1997，70，： | 1 |
| 10 | Landscape diagnosis on different space and time scales-a challenge for landscape planning 显示文摘 | OLAF B RUDOLF K ZDENEK L | 2006 | Landscape Ecol2006，21，： | 1 |
| 11 | Increased levelof cytokines and matrix metalloproteinase in osteoarthritic subchondralbone显示文摘 | Hana Hulejova Veronika Baresova Zdenek Klezl | 2007 | Cytokine2007，38，3： | 1 |
| 12 | Deformation behav- ior of Mg-Li-AI alloys显示文摘 | ZDENEK D LUZANKA T STANISLAV K | 2004 | Journal of Alloys and Compounds2004，378，： | 1 |
| 13 | Applying social marginal cost pricing in rail PPPs: Presentstate, drawbacks and ways forward 显示文摘 | Joao Bernardino Zdenek Hrebicek Carlos Marques | 2010 | Transportation Economics2010，，30： | 1 |
| 14 | Closure and Stable Hamiltonian Properties in Claw -free Graphs 显示文摘 | Stephan Brandt Odile Favaron Zdenek Ryja cek | 2000 | J Graph Theory2000，34，： | 1 |
| 15 | HPLC determination of lincomycin in premixes and feedstuffs with solid-phase extraction on HLB OASIS and LC-MS/MS confirmation显示文摘 | MICHAL D ZDENEK S MICHAL H | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，40，： | 1 |
| 16 | Calculation of element distributions between inorganic and organic parts of coal显示文摘 | Zdenek Weiss Vaclav Roubicek | 1997 | Fuel1997，76，1415： | 1 |
| 17 | Mosquito-borne viruses in Europe显示文摘 | Zdenek H | 2008 | Parasitol Res2008，103，1： | 1 |
| 18 | Parallel explicit finite element solid dynamics with domain decomposition and message passing: dual partitioning scalability显示文摘 | Petr Krysl Zdenek Bittnar | 2001 | Computers and Structures2001，79，： | 1 |
| 19 | Application of capillary elcctorchromatography using macroporous polyacrylamide columns for the analysis of lignans from seeds of Schisandra chincnsis显示文摘 | Kvasnickova Leona Glatz Zdenek Sterbova Hana | 2001 | J Chrom A2001，916，： | 1 |
| 20 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
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