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| 1 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 2 | Malignant colorectal polyps显示文摘Nowadays, the number of cases in which malignant colorectal polyps are removed is increasing due to colorectal cancer screening programmes. Cancerous polyps are classified into non-invasive high grade neoplasia (NHGN), when the cancer has not reached the muscularis mucosa, and malignant polyps, classed as T1, when they have invaded the submucosa. NHGN is considered cured with polypectomy, while the prognosis for malignant polyps depends on various morphological and histological factors. The prognostic factors include, sessile or pedunculated morphology of the polyp, whether partial or en bloc resection is carried out, the degree of differentiation of the carcinoma, vascular or lymphatic involvement, and whether the polypectomy resection margin is tumor free. A malignant polyp at T1 is considered cured with polypectomy ifit is a pedunculated polyp (Ip of the Paris classification), it has been completely resected, it is not poorly differentiated, the resection edge is not affected by the tumor and there is no vascular or lymphatic involvement. The sessile malignant polyp (Is of the Paris classification) at T1 is considered not cured with polypectomy. Only in some cases (e.g. older people with high surgical risk) local excision(polypectomy or endoscopic submucosal dissection or conventional endoscopic mucosal resection) is considered the definitive treatment. | Luis Bujanda Angel Cosme Ines Gil Juan I Arenas-Mirave | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 4 | Development of a group-specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 5 | Current approaches to reducing gastrointestinal toxicity of low- dose aspirin显示文摘 | Angel I L | 2001 | Am J Med2001，110，1： | 1 |
| 6 | B6zier curve and surface fitting of 3D point clouds through genetic algorithms显示文摘 | AKEMI G ANDRes I ANGEL C | 2007 | Lecture Notes in Computer Science2007，4706，： | 1 |
| 7 | Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas显示文摘 | Angele S Treilleux I Taniere P | 2000 | Clin Cancer Res2000，6，9： | 1 |
| 8 | Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat显示文摘 | Pichat P Angel I Arbilla S | 1998 | Arzneimittelforschung1998，48，2： | 1 |
| 9 | Microtia:a clinical and genetie study at the National Institute of Pediatrics in Mexico City显示文摘 | Llano-Rivas I Gonzalez-del Angel A del Cnstillo V | 1999 | Arch Med Res1999，30，2： | 1 |
| 10 | Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat显示文摘 | Pichat P Angel I Arbilla S | 1998 | Arzneimittelforschung1998，48，2： | 1 |
| 11 | Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists显示文摘 | MORALES-RAMOS ANGEL I MECOM JOHN S KIESOW TERRY J | 2008 | Bioorg Med Chem Lett2008，18，23： | 1 |
| 12 | Recycled concrete made with different natural coarse aggregates exposed to high temperature 显示文摘 | Zega Claudio Javier Maio Angel Antonio I)i | 2009 | Construction and Building Materials2009，23，5： | 1 |
| 13 | Clinical pharmacology of DP-99 in healthy volunteerss First administration to humans显示文摘 | Rosenherg G Angel I Kozak A | 2005 | British Journal of Chlinical Pharmacology2005，60，1： | 1 |
| 14 | Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat显示文摘 | Pichat P Angel I Arbilla S | 1998 | Arzneimittelforschung1998，48，2： | 1 |
| 15 | Developmental patterns of selected characteristics of the gastrointestinal tract of young turkeys显示文摘 | Sell J I Angel C R Piquer F | 1991 | Poultry Science1991，70，5： | 1 |
| 16 | Mechanistical and non-linear modeling approaches to in-duct desulfurization显示文摘 | Aurora G Jose A M Angel I | 2005 | Chemical Engineering and Processing2005，44，7： | 1 |
| 17 | CpG 7909 adjuvant plus hepatitis B virus vaccination in HIV-infected adults achieves long-term seroprotection for up to 5 years显示文摘 | Cooper CL Angel JB Seguin I | 2008 | Clin Infect Dis2008，46，8： | 1 |
| 18 | Chondrogenitor cells and gene therapy显示文摘 | YOO J U MANDELL I ANGELE P | 2000 | Clin Orthop2000，，： | 1 |
| 19 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 20 | Influence of the Hard-to-Soft Segment Ratio on Adhesion of Water-Borne Polyurethane Adhesive显示文摘 | Prez-Limifiana Angeles M Ar(tn-A i s | 2007 | Adhesion Science2007，21，8： | 1 |
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