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| 1 | Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province显示文摘AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 ( CYP2 E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitroscoamines and Iow molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2Elpolymorphisms are associated with risk s of gastric cancer.METHODS: We conducted a population based case-control study in Changle county, Fujian Province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including dsmographic characteristcs, diet intake, and alcohol and tobacco consumption of indivduals in our study were completed by a standardized questionnaire. PCR-RFLP revealed three genotypes: heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in CYP2E1.RESULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 indivduals in gastric cancer group(6.6%),whereas there was only one in the control group (1.1%).However, there was no statistically significan difference between the two groups (two-tailed Fisher′s exact test, P =0.066). Indivduals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR = 1.50) and C2/C2(OR = 7.34) than indivduals in control group (X2 = 4.597, for trend P=0.032). The frequencies of genofypes with the C2allele ( C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele ( C1/C1 genotype )among indivduals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that indivduals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer.CONCLUSION: Polymorphism of CYP2E1 gene may have some effct in the development of gastric cancer in Changle county, Fujian Province. | Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，6： | 25 |
| 2 | Glutathione S-transferases M1,T1 genotypes and the risk of gastric cancer:A case-control study显示文摘AIM Glutathione S-transferases (GSTs are involved in the detoxification of many potential carcinogens and appear to play a critical role in the protection from the effects of carcinogens. The contribution of glutathione Stransferases M1 and T1 genotypes to susceptibility to the risk of gastric cancer and their interaction with cigarette smoking are still unclear. The aim of this study was to determine whether there was any relationship between genetic polymorphisms of GSTM1 and GSTT1 and gastric cancer.METHODS A population based case - control study was carried out in a high-risk area, Changle County, Fujian Province, China. The epidemiological data were collected by a standard questionnaire and blood samples were obtained from 95 incidence gastric cancer cases and 94 healthy controls. A polymerase chain reaction method was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA. Logistic regression model was employed in the data analysis.RESULTS An increase in risk for gastric cancer was found among carriers of GSTM1 null genotype. The adjusted odds ratio (OR) was 2.63 [95% Confidence Interval (95% CI) 1.17-5.88], after controlling for age,gender, cigarette smoking, alcohol drinking, and fish sauce intake. The frequency of GSTT1 null genotype in cancer cases (43.16%) was not significantly different from that in controls (50.00%). However, the risk for gastric cancer in those with GSTM1 null and GSTT1 nonnull genotype was significantly higher than in those with both GSTM1 and GSTT1 non-null genotype (OR = 2.77,95% Cl 1.15- 6.77). Compared with those subjects who never smoked and had normal GSTM1 genotype, Ors were 1.60 (95% CI: 0.62- 4.19) for never smokers with GSTM1 null type, 2.33 (95% CI 0.88- 6.28) for smokers with normal GSTM1, and 8.06 (95% CI 2.83- 23.67) for smokers with GSTM1 null type.CONCLUSIONS GSTM1 gene polymorphisms may be associated with genetic susceptibility of stomach cancer and may modulate tobacco-related carcinogenesis of gastric cancer. | Lin Cai Shun-Zhang Yu Zuo-Feng Zhang Department of Epidemiology.Fujian Medical University,Fuzhou 350004,Fujian Province,ChinaDepartment of Epidemiology,Shanghai Medical University,Shanghai 200032,China Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，4： | 22 |
| 3 | Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system显示文摘Background:Amyloid beta peptide(Aβ)is the main component of extraneuronal senile plaques typical of Alzheimer’s disease(AD)brains.Although Aβis produced by normal neurons,it is shown to accumulate in large amounts within neuronal lysosomes in AD.We have recently shown that under normal conditions the majority of Aβis localized extralysosomally,while oxidative stress significantly increases intralysosomal Aβcontent through activation of macroautophagy.It is also suggested that impaired Aβsecretion and resulting intraneuronal increase of Aβcan contribute to AD pathology.However,it is not clear how Aβis distributed inside normal neurons,and how this distribution is effected when Aβsecretion is inhibited.Methods:Using retinoic acid differentiated neuroblastoma cells and neonatal rat cortical neurons,we studied intracellular distribution of Aβby double immunofluorescence microscopy for Aβ40 or Aβ42 and different organelle markers.In addition,we analysed the effect of tetanus toxin-induced exocytosis inhibition on the intracellular distribution of Aβ.Results:Under normal conditions,Aβwas found in the small cytoplasmic granules in both neurites and perikarya.Only minor portion of Aβwas colocalized with trans-Golgi network,Golgi-derived vesicles,early and late endosomes,lysosomes,and synaptic vesicles,while the majority of Aβgranules were not colocalized with any of these structures.Furthermore,treatment of cells with tetanus toxin significantly increased the amount of intracellular Aβin both perikarya and neurites.Finally,we found that tetanus toxin increased the levels of intralysosomal Aβalthough the majority of Aβstill remained extralysosomally.Conclusion:Our results indicate that most Aβis not localized to Golgi-related structures,endosomes,lysosomes secretory vesicles or other organelles,while the suppression of Aβsecretion increases intracellular intra-and extralysosomal Aβ. | Lin Zheng Angel Cedazo-Minguez Martin Hallbeck Fredrik Jerhammar Jan Marcusson Alexei Terman | 2012 | Translational Neurodegeneration2012，1，1： | 10 |
| 4 | Assessing the benthic quality status of the Bohai Bay(China)with proposed modifications of M-AMBI显示文摘Multivariate AZTI's Marine Biotic Index(M-AMBI) was designed to indicate the ecological status of European coastal areas.Based upon samples collected from 2009 to 2012 in the Bohai Bay,we have tested the response of variations of M-AMBI,using biomass(M-BAMBI) in the calculations,with different transformations of the raw data.The results showed that the ecological quality of most areas in the study indicated by M-AMBI was from moderate to bad status with the worse status in the coastal areas,especially around the estuaries,harbors and outfalls,and better status in the offshore areas except the area close to oil platforms or disposal sites.Despite large variations in nature of the input data,all variations of M-AMBI gave similar spatial and temporal distribution patterns of the ecological status within the bay,and showed high correlation between them.The agreement of new ecological status obtained from all M-AMBI variations,which were calculated according to linear regression,was almost perfect.The benthic quality,assessed using different input data,could be related to human pressures in the bay,such as water discharges,land reclamation,dredged sediment and drilling cuts disposal sites.It seems that M-BAMBI were more effective than M-NABMI(M-AMBI calculated using abundance data) in indicating human pressures of the Bay.Finally,indices calculated with more severe transformations,such as presence/absence data,could not indicate the higher density of human pressures in the coastal areas of the north part of our study area,but those calculated using mild transformation(i.e.,square root) did. | CAI Wenqian BORJA Angel LIN Kuixuan ZHU Yanzhong ZHOU Juan LIU Lusan | 2015 | Acta Oceanologica Sinica2015，34，10： | 5 |
| 5 | A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy显示文摘 | Robert M. Wenham James Lapolla Hui-Yi Lin Sachin M. Apte Johnathan M. Lancaster Patricia L. Judson Jesus Gonzalez-Bosquet Amber Herschberger Laura J. Havrilesky Angeles Alvarez Secord | 2013 | Gynecologic Oncology2013，，1： | 2 |
| 6 | Cytokinin oxidase regulates rice grain production显示文摘 | Ashikari M Sakakibara H Lin S Y Yamamoto T Takashi T Nishimura A Angeles E R Qian Q Kitano H Matsuoka M | 2005 | Science2005，309，： | 1 |
| 7 | Mobile Cultures of Migrant Workers in Southern China:Informal Literacies in the Negotiation of(New)Social Relations of the New Working Women显示文摘 | Angel Lin Avin Tong | 2008 | K now Techn Pol2008，，21： | 1 |
| 8 | Mobile Cultures of Migrant Workers in Southern China:Informal Literacies in the Negotiation of(New)Social Relations of the New Working Women显示文摘 | Angel Lin Avin Tong | 2008 | K now Techn Pol2008，，21： | 1 |
| 9 | Rubbery solid electrolytes with dominant cationic transport and high ambient conductivity显示文摘 | Angell C A Lin C and Sanchez E | 1993 | Nature1993，362，6416： | 1 |
| 10 | Cytokinin oxidase regulates rice grain production 显示文摘 | Ashikari M Sakakibara H Lin S Yamamoto T Takashi T Nishimura A Angeles E R Qian Q Kitano H Matsuoka M | 2005 | Science2005，309，741： | 1 |
| 11 | A global performance index for the kinematic optimization of robotic manipulators 显示文摘 | Gosse lin C Angeles J | 1991 | Transactions of the ASME1991，113，3： | 1 |
| 12 | Bilingualism or linguistic segregation 1 ? Symbolic domination, resistance and code switching in Hong Kong schools显示文摘 | Angel M.Y. Lin | 1996 | Linguistics and Education1996，，1： | 1 |
| 13 | Serum microRNAs in clear cell carcinoma of the ovary显示文摘 | Angel Chao Chyong-Huey Lai Hua-Chien Chen Chiao-Yun Lin Chia-Lung Tsai Yun-Hsin Tang Huei-Jean Huang Chen-Tao Lin Min-Yu Chen Kuang-Gen Huang Hung-Hsueh Chou Ting-Chang Chang Shu-Jen Chen Tzu-Hao Wang | 2014 | Taiwanese Journal of Obstetrics & Gynecology2014，，： | 1 |
| 14 | Lively children trapped in an Island of disadvantage: verbal play of Cantonese working-class schoolboys in Hong Kong显示文摘 | ANGEL MEI YI LIN | 2009 | International Journal of the Sociology of Language2009，，1： | 1 |
| 15 | Cytokinin oxidase regulates rice grain production显示文摘 | Ashikari M Sakakibara H Lin S Y Yamamoto T Takashi T Nishimura A Angeles E R Qian Q Kitano H Matsuoka M | 2005 | Science2005，309，5735： | 1 |
| 16 | Isolation of a rice regeneration quantitative trait loci gene and its application to transformation systems显示文摘 | Nishimura A Ashikari M Lin S Takashi T Angeles E R Yamamoto T Matsuoka M | | 0，，33： | 1 |
| 17 | Meigs' syndrome with elevated serum CA125显示文摘 | Lin JY Angel C Sickel JZ | 1992 | Obstet Gynecol1992，80，32： | 1 |
| 18 | Meigs' syndrome with elevated serum CA125显示文摘 | Lin JY Angel C Sickel JZ | 1992 | Obstet Gynecol1992，80，： | 1 |
| 19 | Meigs′ syndrome with elevated serum CA-125显示文摘 | Lin JY Angel C Sickel JZ | 1992 | Obstet Gynecol1992，80，32： | 1 |
| 20 | Beyond Linguistic Purism in Language-in-education Policy and Practice: Exploring Bilingual Pedagogies in a Hong Kong Science Classroom 显示文摘 | Angel Lin | 2006 | Language and Education2006，20，4： | 1 |
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