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| 1 | Effects of vegetation type on soil microbial community structure and catabolic diversity assessed by polyphasic methods in North China显示文摘土壤微生物在生态的过程起一个主要作用并且仔细与被联系未葬植物群落。以便理解植被的效果在土壤的特征上打微生物引起的社区,土壤微生物引起的社区被板计数,磷脂脂肪酸( PLFA )和 Biolog 估计在五植物群落的微板技术,即,大豆地( SF ),人工的草地(在),人工的灌木(作为),自然灌木( NS ),和在 Jinan 的玉米地( MF ),山东省,诺思中国。结果证明那植物差异在微生物引起的生物资源上有小看得清的效果但是在 Biolog microplate.Legumes 的利用底层的平均上的积极影响能显著地提高文化微生物,微生物引起的生物资源,和社区的数字分解代谢的差异。除了荚统治的 SF ,真菌和微生物引起的社区的分解代谢的差异的生物资源比在在另外的 vegetationtypes.These 下面的经常扰乱的土壤结果证实植物种类的那个高数字在在 NS 下面的更少的扰乱的土壤是更高的,荚,并且到支持的自然植被 typest 结束与更高的功能玷污微生物引起的社区。现在的学习也发现了在有教养的细菌和细菌的社区的分解代谢的差异的数字之间的重要关联。不同研究方法在这研究导致了改变的结果。几条途径的联合为精确地在许多尊重描述微生物引起的社区的特征被推荐。 | HAN Xue-mei WANG Ren-qing LIU Jian WANG Meng-cheng ZHOU Juan GUO Wei-hua | 2007 | Journal of Environmental Sciences2007，19，10： | 60 |
| 2 | Clinical and procedural predictors of no-ref low in patients with acute myocardial infarction after primary percutaneous coronary intervention显示文摘BACKGROUND: The treatment of acute myocardial infarction(AMI) is thought to restore antegrade blood flow in the infarct-related artery(IRA) and minimize ischemic damage to the myocardium as soon as possible. The present study aimed to identify possible clinical predictors for no-refl ow in patients with AMI after primary percutaneous coronary intervention(PCI).METHODS: A total of 312 consecutive patients with AMI who had been treated from January 2008 to December 2010 at the Cardiology Department of East Hospital, Tongji University School of Medicine were enrolled in this study. Inclusion criteria were:(i) patients underwent successfully primary PCI within 12 hours after the appearance of symptoms; or(ii) patients with ischemic chest pain for more than 12 hours after a successful primary PCI within 24 hours after appearance of symptoms. Exculsion criteria were:(i) coronary artery spasm;(ii) diameter stenosis of the culprit lesion was ≤50% and coronary blood f low was normal;(iii) patients with severe left main coronary or multivessel disease, who had to require emergency revascularization. According to thrombolysis in myocardial infarction(TIMI), the patients were divided into a reflow group and a no-reflow group. The clinical data, angiography f indings and surgical data were compared between the two groups. Univariate and multivariate logistic regressions were used to determine the predictors for no-ref low.RESULTS: Fifty-four(17.3%) of the patients developed NR phenomenon after primary PCI. Univariate analysis showed that age, time from onset to reperfusion, systolic blood pressure(SBP) on admission, Killip class of myocardial infarction, intra-aortic balloon pump(IABP) use before primary PCI, TIMI flow grade before primary PCI, type of occlusion, thrombus burden on baseline angiography, target lesion length, reference luminal diameter and method of reperfusion were correlated with no-reflow(P<0.05 for all). Multiple logistic regression analysis identified that age >65 years [OR=1.470, 95% confi dence interval(CI) 1.460–1.490, P=0.007], long time from onset to reperfusion >6 hours(OR=1.270, 95%CI 1.160–1.400, P=0.001), low SBP on admission <100 mmHg(OR=1.910, 95%CI 1.018–3.896, P=0.004), IABP use before PCI(OR= 1.949, 95%CI 1.168–3.253, P=0.011), low(≤1) TIMI fl ow grade before primary PCI(OR=1.100, 95%CI 1.080–1.250, P<0.001), high thrombus burden(OR=1.600, 95%CI 1.470–2.760, P=0.030), and long target lesion(OR=1.948, 95%CI 1.908–1.990, P=0.019) on angiography were independent predictors of no-refl ow.CONCLUSION: The occurrence of no-refl ow after primary PCI for acute myocardial infarction can predict clinical, angiographic and procedural features. | Hua Zhou Xiao-yan He Shao-wei Zhuang Juan Wang Yan Lai Wei-gang Qi Yi-an Yao Xue-bo Liu | 2014 | World Journal of Emergency Medicine2014，5，2： | 46 |
| 3 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 4 | ;he regulation of TGF-β/SMAD signaling by protein deubiquitination显示文摘 | Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van Dam Long Zhang Fangfang Zhou | 2014 | Protein & Cell2014，5，7： | 27 |
| 5 | Accelerated Degradation Reliability Modeling and Test Data Statistical Analysis of Aerospace Electrical Connector显示文摘As few or no failures occur during accelerated life test,it is difficult to assess reliability for long-life products with traditional life tests.Reliability assessment using degradation data of product performance over time becomes a significant approach.Aerospace electrical connector is researched in this paper.Through the analysis of failure mechanism,the performance degradation law is obtained and the statistical model for degradation failure is set up;according to the research on statistical analysis methods for degradation data,accelerated life test theory and method for aerospace electrical connector based on performance degradation is proposed by improving time series analysis method,and the storage reliability is assessed for Y11X series of aerospace electrical connector with degradation data from accelerated degradation test.The result obtained is basically consistent with that obtained from accelerated life test based on failure data,and the two estimates of product's characteristic life only have a difference of 8.7%,but the test time shortens about a half.As a result,a systemic approach is proposed for reliability assessment of highly reliable and long-life aerospace product. | CHEN Wenhua LIU Juan GAO Liang PAN Jun ZHOU Shengjun | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 22 |
| 6 | Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy显示文摘Acute-on-chronic 肝失败(ACLF ) 是严重威胁生活的复杂并发症。肝移植是唯一的可得到的治疗学的选择;然而,几限制在病人限制了它的使用。为 ACLF 的可选的治疗收到了很多利息的 corticosteroids 的使用。在它的使用后面的基本原理是在开始并且永久维持肝的损坏的免疫系统的可能的角色。以便估计在 myeloid 之间的关系树枝状的房间(mDCs ) 和 methylprednisolone (MP ) 的功效为肝炎 B 病毒(HBV ) 的治疗联系了 ACLF 病人,我们招募了在 10 天的间隔接受了 MP 治疗的 30 个联系 HBV 的 ACLF 病人;26 个病人接待了保守人士医药(厘米) 管理作为控制。DC 子集的功能与健康题目相比在这些 ACLF 病人是更低的。与幸存者相比,另外, dead/transplanted 病人在两个组有更低的功能的 mDC。而且,一在基线的 mDC 的减少的数字与 ACLF 病人的高死亡被联系。重要地, MP 治疗在 28 天的死亡导致了重要减少,并且所有 MP 病人在 10 天 MP 治疗以内在传播 mDC 数字展出了起始的快速的减少。随后, MP 幸存者在超过 30 % 减少在全部的 bilirubin 层次伴随的 mDC 数字显示了连续增加;。然而, MP dead/transplanted 病人与幸存者相比缺乏这些顺序的回答。这条证据强烈建议在基线和在治疗的结束的 mDC 数字的恢复的更高的 mDC 数字可以在 ACLF 病人为对 corticosteroid 治疗的有利反应代表一个预示的标记。 | Juan Zhao Ji-Yuan Zhang Hong-Wei Yu Yu-Lan He Jing-Jing Zhao Juan Li Yue-Ke Zhu Qin-Wei Yao Jin-Huan Wang Hai-Xia Liu Shu-Yun Shi Zheng-Sheng Zou Xiang-Sheng Xu Chun-Bao Zhou Fu-Sheng Wang Qing-Hua Meng | 2012 | Cellular & Molecular Immunology2012，9，5： | 23 |
| 7 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 8 | New alkylamides from pericarps of Zanthoxylum bungeanum显示文摘二新不饱和的 alkylamides (2E,7E,9E )-N-(2-hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide (1 ) 并且(2E,6E,8E ) 和六已知的混合物(38 ) 的 -N-(2-hydroxy-2-methylpropyl)-10-oxo-2,6,8-decatrienamide (2 ) 从 Zanthoxylum bungeanum 的果皮被孤立。他们的结构根据广泛的分光镜的分析被阐明,包括 MS,红外, 1D 和 2D NMR 实验。 | Shuai Huang Lei Zhao Xian Li Zhou Mei Ying Cui Juan Wang Jie Weng | 2012 | Chinese Chemical Letters2012，23，11： | 21 |
| 9 | Protective effect of selenium-enriched lactobacilluson CCI_4-induced liver injury in mice and its possible mechanisms显示文摘AIM: To study the protective effects and mechanisms of Se-enriched lactobacillus on liver injury caused by carbon tetrachloride (CCl4) in mice.MWTHODS: Seventy-two ICR mice were randomly divided into four groups: normal group, CCl4-induced model group,low Se-enriched lactobacillus treatment group (L-Se group),and high Se-enriched lactobacillus treatment group (H-Se group). During a 3-wk experimental period, the common complete diet was orally provided daily for normal group and model group, and the mice in L-Se and H-Se groups were given a diet with 2 and 4 mg of organoselenium from Se-enriched lactobacillus per kg feed, respectively. From the 2nd wk of experiment, the model group, L-Se group,and H-Se group received abdominal cavity injection of olive oil solution containing 500 mL/L CCl4 (0.07 mL/100 g body mass) to induce liver injury, and the normal group was given olive oil on every other day for over 2 wk. In the first 2 wk post injection with CCl4, mice in each group were killed. The specimens of blood, liver tissue, and macrophages in abdominal cavity fluid were taken. Then the activities of the following liver tissue injury-associated enzymes including glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as malondialdehyde (MDA) content were assayed. Changes of phagocytic rate and phagocytic index in macrophages were observed with Wright-Giemsa stain. Plasma TNF-α level was measured by radioimmunoassay. The level of intracellular free Ca2+ ([Ca2+]i) in hepatocytes was detected under a laser scanning confocal microscope.RESULTS: During the entire experimental period, the AST and ALT activities in liver were greatly enhanced by CCl4 and completely blunted by both low and high doses of Se-enriched lactobacillus. The Se-enriched lactobacillus-protected liver homogenate GSH-Px and SOD activities were higher or significantly higher than those in model group and were close to those in normal group. CCl4 significantly increased MDA content in liver homogenates, while administration of Se-enriched lactobacillus prevented MDA elevation. Phagocytic rate and phagocytic index of macrophages decreased after CCl4 treatment compared to those in normal control, but they were dramatically rescued by Se-enriched lactobacillus, showing a greatly higher phagocytic function compared to model group. CCl4 could significantly elevate plasma TNF-α and hepatocyte [Ca2+]i level, which were also obviously prevented by Se-enriched lactobacillus.CONCLUSION: Se-enriched lactobacillus can intervene in CCl4-induced liver injury in mice by enhancing macrophage function activity to keep normal and beneficial effects,elevating antioxidant-enzyme activities and reducing lipid peroxidation reaction, inhibiting excessive release of TNF-α,preventing the dramatic elevation of [Ca2+]i in hepatocytes. | Long Chen Dao-Dong Pan Juan Zhou Ying-Zi Jiang | 2005 | World Journal of Gastroenterology2005，11，37： | 19 |
| 10 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 11 | Association of higher resistin levels with inflammatory activation and endothelial dysfunction in patients with essential hypertension显示文摘 | FANG Chang LEI Juan ZHOU Shu-xian ZHANG Yu-ling YUAN Gui-yi WANG Jing-feng | 2013 | Chinese Medical Journal2013，，4： | 17 |
| 12 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 13 | Relationship between homocysteine level and prognosis of elderly patients with acute ischemic stroke treated by thrombolysis with recombinant tissue plasminogen activator显示文摘BACKGROUND Acute ischemic stroke(AIS)is mainly caused by cerebral blood flow disorders,which further leads to ischemic brain necrosis or encephalomalacia.The role of homocysteine(Hcy),an independent risk factor for cardiovascular disease,in the development of atherosclerosis is gradually revealed.However,studies are still rare and little is known about the relationship of Hcy level with the prognosis.AIM To explore the relationship between Hcy level and prognosis in elderly patients with AIS after thrombolytic therapy with recombinant tissue plasminogen activator(rtPA).METHODS A total of 120 patients with acute ischemic stroke who were admitted to Jingzhou Central Hospital and underwent recombinant tissue plasminogen activator treatment were randomly selected from January 2017 to December 2018.They were divided into two groups according to the level of Hcy,with 60 patients in each group.Patients with Hcy≥18.54 umol/L were included into a high-level group and those with Hcy<18.54 umol/L were included into a low-level group.The outcomes were analyzed in the two groups after the treatment.RESULTS The National institute of Health Stroke Scale(NIHSS)scores were significantly higher in the high-level group than in the low-level group before and 1 h after the treatment(P<0.05).There was no significant difference in NIHSS scores between the two groups at 12 and 24 h after the treatment(P>0.05).The Modified Rankin scale(MRS)scores were significantly higher in the high-level group than in the low-level group before and 1 h after the treatment(P<0.05).There was no significant difference in MRS scores between the two groups at 12 and 24 h after the treatment(P>0.05).NIHSS and MRS scores were positively correlated with the prognosis after thrombolytic therapy(P<0.05).CONCLUSION The level of Hcy is closely related to the prognosis of elderly patients with acute ischemic stroke,and after rtPA treatment,the prognosis of elderly patients is improved significantly. | Juan Li Fan Zhou Feng-Xue Wu | 2019 | World Journal of Clinical Cases2019，7，22： | 16 |
| 14 | Heterotopic pancreas in the gastrointestinal tract显示文摘Heterotopic pancreas is defined as pancreatic tissue found outside the usual anatomical location of the pancreas. It is often an incidental finding and can be found at different sites in the gastrointestinal tract. It may become clinically evident when complicated by pathological changes such as inflammation, bleeding, obstruction, and malignant transformation. In this report, a 60-year-old man with carcinoid syndrome caused by heterotopic pancreatic tissue in the duodenum is described, along with a 62-year-old man with abdominal pain caused by heterotopic pancreatic tissue in the gastric antrum. The difficulty of making an accurate diagnosis is highlighted. The patients remain healthy and symptom-free after follow-up of 1 year. Frozen sections may help in deciding the extent of resection intraoperatively. Although heterotopic pancreas is rare, it should be considered in the differential diagnosis of gastrointestinal stromal tumor. | Zhou Yuan Jie Chen Qi Zheng Xin-Yu Huang Zhe Yang Juan Tang | 2009 | World Journal of Gastroenterology2009，15，29： | 15 |
| 15 | Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults显示文摘Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography(n = 604), and general cognitive abilities were measured using the Montreal Cognitive Assessment(MoCA). Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features: higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impairedthe processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment. | Jing Yu Tao Su Ting Zhou Yingge He Jing Lu Juan Li Rongqiao He | 2014 | Neuroscience Bulletin2014，30，2： | 14 |
| 16 | Salvianolate Reduces Murine Myocardial Ischemia and Reperfusion Injury via ERK1/2 Signaling Pathways in vivo显示文摘Objective:To analyze the effects of salvianolate on myocardial infarction in a murine in vivo model of ischemia and reperfusion(l/R) injury.Methods:Myocardial l/R injury model was constructed in mice by 30 min of coronary occlusion followed by 24 h of reperfusion and pretreated with salvianolate 30 min before l/R(SAL group).The SAL group was compared with SHAM(no l/R and no salvianolate),l/R(no salvianolate),and ischemia preconditioning(IPC) groups.Furthermore,an ERK1/2 inhibitor PD98059(1 mg/kg),and a phosphatidylinositol-3-kinase(PI3-K) inhibitor,LY294002(7.5 mg/kg),were administered intraperitoneal injection(i.p) for 30 min prior to salvianolate,followed by l/R surgery in LY and PD groups.By using a double staining method,the ratio of the infarct size(IS) to left ventricle(LV) and of risk region(RR) to LV were compared among the groups.Correlations between IS and RR were analyzed.Western-blot was used to detect the extracellular signal-regulated kinase 1/2(ERK1/2) and protein kinase B(AKT) phosphorylation changes.Results:There were no significant differences between RR to LV ratio among the SHAM,l/R,IPC and SAL groups(P>0.05).The SAL and IPC groups had IS of 26.1%± 1.4%and 22.3%±2.9%of RR,respectively,both of which were significantly smaller than the l/R group(38.5%±2.9%of RR,P<0.05,P<0.01,respectively).Moreover,the phosphorylation of ERK1/2 was increased in SAL group(P<0.05),while AKT had no significant change.LY294002 further reduced IS,whereas the protective role of salvianolate could be attenuated by PD98059,which increased the IS.Additionally,the IS was not linearly related to the RR(r=0.23,0.45,0.62,0.17,and 0.52 in the SHAM,l/R,SAL,LY and PD groups,respectively).Conclusion:Salvianolate could reduce myocardial l/R injury in mice in vivo,which involves an ERK1/2 pathway,but not a PI3-K signaling pathway. | QI Jian-yong YU Juan HUANG Dong-hui GUO Li-heng WANG Lei HUANG Xin HUANG Hai-ding ZHOU Miao ZHANG Min-zhou Jiashin Wu | 2017 | Chinese Journal of Integrative Medicine2017，23，1： | 14 |
| 17 | Polycyclic aromatic hydrocarbon biodegradation and extracellular enzyme secretion in agitated and stationary cultures of Phanerochaete chrysosporium显示文摘多不的芳族烃的胞外酶分泌物和简历降级(哼) 被学习在鼓动并且 Phanerochaete chrysosporium 的浅静止液体培养。Veratryl 酒精和 Tween80 作为木质素过氧化物酶(嘴唇) 和锰过氧化物酶(MnP ) 被加到文化 inducer 分别地。浅静止文化对酶的生产合适,而鼓动的文化由便于分裂期间团转移提高了全面简历降级哼进水的阶段。一个嘴唇激发器的使用, veratryl 酒精,增加没哼降级但是显著地提高的嘴唇活动。相反, Tween80 增加了两 MnP 分泌物并且哼在浅静止文化的降级。在另一方面,高哼降级当可检测的嘴唇和 MnP 活动不在时在鼓动的文化被观察。结果与 PAH 降级有关直接建议细胞外的过氧化物酶活动不在提升是重要的,并且增加的溶解度而非酶活动可以是更多哼降级。 | DING Juan CONG Jun ZHOU juan GAO Shixiang | 2008 | Journal of Environmental Sciences2008，20，1： | 14 |
| 18 | Breviscapine inhibits high glucose-induced proliferation and migration of cultured vascular smooth muscle cells of rats via suppressing the ERK1/2 MAPK signaling pathway显示文摘瞄准: 调查 breviscapine 的影响,从 Erigeron breviscapus 提取的 flavonoid,在脉管的光滑的肌肉房间(VSMC ) 的增长和迁居上在高葡萄糖媒介和内在的机制有教养。 | Meng HE Zhi-min XUE Juan LI Bin-quan ZHOU | 2012 | Acta Pharmacologica Sinica2012，33，5： | 14 |
| 19 | Effect of CO_2 Enrichment on the Growth and Nutrient Uptake of Tomato Seedlings显示文摘Exposing tomato seedlings to elevated CO2 concentrations may have potentially profound impacts on the tomato yield and quality. A growth chamber experiment was designed to estimate how different nutrient concentrations influenced the effect of elevated CO2 on the growth and nutrient uptake of tomato seedlings. Tomato (Hezuo 906) was grown in pots placed in controlled growth chambers and was subjected to ambient or elevated CO2 (360 or 720μL L-1) and four nutrient solutions of different strengths (1/2-, 1/4-, 1/8-, and 1/16-strength Japan Yamazaki nutrient solutions) in a completely randomized design. The results indicated that some agricultural characteristics of the tomato seedlings such as the plant height, stem thickness, total dry and fresh weights of the leaves, stems and roots, the G value (G value = total plant dry weight/seedling age), and the seedling vigor index (seedling vigor index = stem thickness/(plant height×total plant dry weight) increased with the elevated CO2, and the increases were strongly dependent on the nutrient solution concentrations, being greater with higher nutrient solution concentrations. The elevated CO2 did not alter the ratio of root to shoot. The total N, P, K, and C absorbed from all the solutions except P in the 1/8- and 1/16-strength nutrient solutions increased in the elevated CO2 treatment. These results demonstrate that the nutrient demands of the tomato seedlings increased at elevated CO2 concentrations. | LI Juan ZHOU Jian-Min DUAN Zeng-Qiang DU Chang-Wen WANG Huo-Yan | 2007 | Pedosphere2007，17，3： | 13 |
| 20 | Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)显示文摘Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China.TBC is semi-volatile and can accumulate in the lipid of some species,but little is known about its effect on aquatic organisms.We exposed adult zebrafish to 0,0.25,1 and 4mg/L TBC for 28 d and measured the effect on survival,growth,histopathology,hormone levels,enzyme activity,and gene expression.TBC exposure had no effect on survival or growth.We observed significant damage to the liver and gill,including hepatocellular swelling and fatty degeneration in the liver as well as proliferation and edema of epithelial cells in the gills.In addition,exposure to 4mg/L TBC induced proliferation of goblet cells in the intestine of both sexes,acellular areas in the testis,and thinly scattered vitellogenic granules in vitellogenic oocytes.TBC exposure had no effect on the levels of thyroid hormones,testosterone,estradiol,liver superoxide dismutase activity,malondialdehyde content,and brain cholinesterase activity.By contrast,hepatic vitellogenin and cytochrome P4501A gene expression was significantly down-regulated in both male and female zebrafish in response to TBC exposure.Our results suggest that exposure to TBC causes a variety of potential reproductive and endocrine toxic effects. | ZHANG Xu LI Juan CHEN MinJie WU Le ZHANG Chi ZHANG Jie ZHOU QunFang LIANG Yong | 2011 | Chinese Science Bulletin2011，56，15： | 13 |
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