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| 1 | Epigenetic basis of Alzheimer disease显示文摘Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD.In this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD.The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD. | Angeles C Tecalco-Cruz JosuéO Ramírez-Jarquín María E Alvarez-Sánchez Jesus Zepeda-Cervantes | 2020 | World Journal of Biological Chemistry2020，11，2： | 4 |
| 2 | Outcomes of critically ill cancer patients with Acinetobacter baumannii infection显示文摘AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) infection.METHODS: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between January 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not required.RESULTS: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, respectively.CONCLUSION: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in the first day of stay in the ICU. | Silvio A ?amendys-Silva Paulina Correa-García Francisco J García-Guillén María O González-Herrera Américo Pérez-Alonso Julia Texcocano-Becerra Angel Herrera-Gómez Patricia Cornejo-Juárez Abelardo Meneses-García | 2015 | World Journal of Critical Care Medicine2015，4，3： | 3 |
| 3 | Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer显示文摘Estrogen receptor alpha(ERα) is detected in more than 70% of the cases of breast cancer. Nuclear activity of ERα, a transcriptional regulator, is linked to the development of mammary tumors, whereas the extranuclear activity of ERα is related to endocrine therapy resistance. ERα polyubiquitination is induced by the estradiol hormone, and also by selective estrogen receptor degraders, resulting in ERα degradation via the ubiquitin proteasome system. Moreover, polyubiquitination is related to the ERα transcription cycle, and some E3-ubiquitin ligases also function as coactivators for ERα. Several studies have demonstrated that ERα polyubiquitination is inhibited by multiple mechanisms that include posttranslational modifica-tions, intera-ctions with coregula-tors, a-nd forma-tion of specific protein complexes with ERα. These events are responsible for an increase in ERα protein levels and deregulation of its signaling in breast cancers. Thus, ERα polyubiquitination inhibition may be a key factor in the progression of breast cancer and resistance to endocrine therapy. | Angeles C Tecalco-Cruz Josué O Ramírez-Jarquín | 2018 | World Journal of Clinical Oncology2018，9，4： | 2 |
| 4 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004，，18： | 1 |
| 5 | Radiofrequency volumetric tissue reduction for treatment of turbinate hypertrophy in children显示文摘 | O'CONNOR-REINA C GARCIA-IRIATE M T ANGEL D G | 2007 | Int J Pediatr Othrhinolaryn- go12007，71，4： | 1 |
| 6 | McCullough Angioleiomyoma on the Hard palate 显示文摘 | AI - amad SH Angel C O 'Grady JF | 2006 | Oral Oncol2006，42，： | 1 |
| 7 | Building a production planning process with an approach based on CIMOSA and workflow management systems显示文摘 | ANGEL O FRANCISCO L LORENZO R | 1999 | Computers in Industry1999，40，11： | 1 |
| 8 | Mass spectrometric determination of pentachlorophenol in honey显示文摘 | Muio Miguel Angel Fernández Lozanoa Jesús Simal | 1991 | Analytica Chimica Acta1991，247，1： | 1 |
| 9 | Faster anaerobic decomposition of a brittle straw rice mutant:implications for residue management显示文摘 | JOHNSON S E ANGELES O R BRAR D S | | 0，，7： | 1 |
| 10 | Multifocal manifestation does not affect vascular invasion of hepatocellular carcinoma:implications for patient selection in liver transplantation显示文摘 | L(o) he F Angele MK Rentsch M | 2007 | Clin Transplant2007，21，6： | 1 |
| 11 | Outcome analysis of individualized vestibular rehabilitation protocols 显示文摘 | Black F O Angel C R Pesznecker S C | 2000 | Am J Otol2000，21，4： | 1 |
| 12 | Soil solution sampling for organic acids in rice paddy soils显示文摘 | Angeles O R Johnson S E Buresh R J | 2006 | Soil Science Society of America Journal2006，70，1： | 1 |
| 13 | Recent changes in landscape structure and function in a mediterranean region of SW Spain (1950–1984)显示文摘 | Rocío Fernandez Ales Angel Martin Fernando Ortega Enrique E. Ales | 1992 | Landscape Ecology1992，，1： | 1 |
| 14 | Systemic spread of sequence-specific transgene RNA degradation in plants in initiated by localized introduction of ectopic promoterless DNA显示文摘 | VAIN P ANGELL S | 1998 | Cell1998，95，： | 1 |
| 15 | Radiofrequency volumetric tissue reduction for treatment of turbinate hypertrophy in children显示文摘 | O′Connor-Reina C Garcia-Iriarte MT Angel DG | 2007 | Int J Pediatr Otorhinolaryngol2007，71，4： | 1 |
| 16 | Size-minimization of planar cam mechanisms显示文摘 | NAVARRO O WU C J ANGELES J | 2001 | Mechanism and Machine Theory2001，36，3： | 1 |
| 17 | Microwave assisted synthesis and crystal structures of 2 - imid- azoline: and imidazoles 显示文摘 | ANTONIO H ANGEL D O MANADEL C M | 2006 | Tetrahedron2006，62，： | 1 |
| 18 | European multi-centre study of the Nucleus Hybrid L24 cochlear implant显示文摘 | Thomas Lenarz Chris James Domenico Cuda Alec Fitzgerald O&rsquo Connor Bruno Frachet Johan H.M. Frijns Thomas Klenzner Roland Laszig Manuel Manrique Mathieu Marx Paul Merkus Emmanuel A.M. Mylanus Erwin Offeciers Joerg Pesch Angel Ramos-Macias Alain Robier | 2013 | International Journal of Audiology2013，，12： | 1 |
| 19 | Protective effort of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice显示文摘 | achado A Rodriguez AS Angel O | 2003 | Vaccine2003，21，： | 1 |
| 20 | Importance of temper- ature and anodic medium composition on microbial fuel cell (MFC) performance显示文摘 | Min B Roman O B Angel Ida Ki I | 2008 | Biotechnology Letters2008，30，7： | 1 |
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