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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 3 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3h6xqquqfcq5xb69wx.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Rational Sirna Design for RNA Interference显示文摘 | ANGELA R LEAKE D BOESE Q | | 0，，03： | 1 |
| 5 | Benign versus malignant solid breast masses: US differentiation显示文摘 | GUITA R ANGELA C S | 1999 | Radiology1999，213，： | 1 |
| 6 | Residual C-peptide secretion and endothelial function in patients with type 2 diabetes显示文摘 | Daniela M Emilia R Angela MA | 2003 | Clinical Science2003，105，1： | 1 |
| 7 | Doxorubicin-loaded gelatin nanoparticles stabilized by glutaraldehyde: Involvement of the drug in the cross-linking process 显示文摘 | Leo E Angela Vandelli M Cameroni R | 1997 | In- ternational journal of Pharmaceutics1997，155，1： | 1 |
| 8 | Residual C-peptide secretion and endothelial function in patients with type2 diabetes显示文摘 | Daniela M Emilia R Angela Marie A | 2003 | Clinical Science2003，105，： | 1 |
| 9 | Body mass index and risk of liver cirrhosis in middle aged UK women:prospective study显示文摘 | Bette L Angela B Gillian R | 2010 | BMJ2010，340，11： | 1 |
| 10 | Endophytic bacterial communities of field-grown potato plants and their plant-growth-promoting and antagonistic abilities显示文摘 | ANGELA S BIRGIT R GABRIELE B | 2004 | Microbiol2004，50，： | 1 |
| 11 | 3-(4-{{Benzyl(methyl)amino}methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer′s disease therapy 显示文摘 | Lorna P Angela R Alessandra B | 2003 | J Med Chem2003，46，12： | 1 |
| 12 | Replacement of fish meal in cobia (Rachycentron canadum)diets u- sing an organically certified protein 显示文摘 | Angela N Lunger S R Craig E McLean | 2006 | Aquaculture2006，257，14： | 1 |
| 13 | Mental Workload and Visual Impairment: Differences be- tween Pupil, Blink, and Subjective Rating 显示文摘 | Miguel A R Elisa P Angela C | 2008 | The Spanish Journal of Psychology2008，11，2： | 1 |
| 14 | Small ruminant lentivirus Tat protein induces apoptosis in caprine cells in vitro by the intrinsic pathway显示文摘 | Angela R Stphanie V Tim G | 2009 | Virology2009，383，： | 1 |
| 15 | Synthesis of analogues of calicheamicin and neocarzinostatin chromophore显示文摘 | Alessandra C Angela R M John M | 2004 | Tetrahedron2004，60，： | 1 |
| 16 | The effects of organic protein supplementation upon growth, feed conversion and texture quality parameters of juvenile cobia (Rachycentron canadum ) 显示文摘 | Angela N Lunger S R McLean E | 2007 | Aquaculture2007，264，14： | 1 |
| 17 | What ' s Wrong with Romanian Rural Finance Understanding the Determinants of Private Access to Credit显示文摘 | Junior R Davis Angela Gaburici Paul G Hare | | 0，，06： | 1 |
| 18 | Generation of activated and antigen-specific T cells with cytotoxic activity after co-culture with dendritic cells显示文摘 | Angela M?rten Tim Greten Carsten Ziske Sabine Renoth Bj?rn Sch?ttker Peter Buttgereit Frank Schakowski Alexander von Rücker Tilman Sauerbruch Ingo G. Schmidt-Wolf | 2002 | Cancer ImmunologyImmunotherapy2002，，1： | 1 |
| 19 | 显示文摘 | Kameron R J Gbenga A O Angela K W | 2011 | Journal of Haz- ardous Materials2011，186，1： | 1 |
| 20 | Cultivation -independent population analysis of bacterial endophytes in three potato varieties based on eubacterial and actinomycetes - specific pcr of 16s rRNA genes 显示文摘 | Angela S Birgit R Ulrike P | 2002 | FEMS Microbiology Ecology2002，39，1： | 1 |
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