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| 1 | Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients显示文摘AIM: To evaluate vascular endothelial growth factor(VEGF) and tryptase in hepatocellular cancer(HCC)before and after trans-arterial chemoembolization(TACE).METHODS: VEGF and tryptase serum concentrations were assessed from 71 unresectable HCC patients before and after hepatic TACE performed by binding DC-Beads?to doxorubicin. VEGF levels were examined for each serum sample using the Quantikine Human VEGF-enzyme-linked immuno-absorbent assay(ELISA),whereas tryptase serum concentrations were assessed for each serum sample by means of fluoro-enzyme immunoassay(FEIA) using the Uni-CAP100 tool.Differences between serum VEGF and tryptase values before and after TACE were evaluated using Student t test. Person's correlation was used to assess the degree of association between the two variables.RESULTS: VEGF levels and serum tryptase in HCCpatients before TACE had a mean value and standard deviation(SD) of 114.31 ± 79.58 pg/mL and 8.13± 3.61 μg/L, respectively. The mean levels and SD of VEGF levels and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/mL and 4.02 ±3.03 μg/L. The changes between the mean values of concentration of VEGF and tryptase before treatment and after treatment was statistically significant(P <0.000231 and P < 0.00124, by Wilcoxon-Mann-Whitney respectively). A significant correlation between VEGF levels before and after TACE and between tryptase levels before and after TACE was demonstrated(r =0.68, P = 0.003; r = 0.84, P = 0.000 respectively).CONCLUSION: Our pilot results suggest that the higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy. | Girolamo Ranieri Michele Ammendola Ilaria Marech Annamaria Laterza Ines Abbate Caroline Oakley Angelo Vacca Rosario Sacco Cosmo Damiano Gadaleta | 2015 | World Journal of Gastroenterology2015，21，19： | 13 |
| 2 | Novel agents and new therapeutic approaches for treatment of multiple myeloma显示文摘This review summarizes the therapeutic strategies and the drugs actually in development for the management of myeloma patients. Multiple myeloma is caused by the expansion of monoclonal plasma cells and secretion of M-protein(immunoglobulins, Bence Jones protein and free light chains). Multiple myeloma still remains an incurable disease with a high incidence rate in the elderly, despite the introduction of several new therapeutic agents(bortezomib, lenalidomide and thalidomide) which have changed its natural history. The high heterogeneity of this disease leads to large differences in clinical responses to treatments. Thus, the choice of the best treatment is a difficult issue. However, the introduction of new drugs has made it possible to achieve high response rates and good quality respons-es with long-term disease control. Interactions between tumor cells and their bone marrow microenvironment play a pivotal role in the development, maintenance, and progression of myeloma, inducing also drug resistance. These knowledges have improved treatment options, leading to the approval of new drugs which not only target the malignant cell itself, but also its microenvironment. These agents are in preclinical/early clinical evaluation and they appear to further improve disease control, but their use is still not approved outside of clinical trials. | Roberto Ria Antonia Reale Angelo Vacca | 2014 | World Journal of Methodology2014，4，2： | 10 |
| 3 | Identify multiple myeloma stem cells: Utopia?显示文摘Multiple myeloma(MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of cancer stem cells(CSCs) has been demonstrated in many solid and hematologic tumors, so the idea of CSCs has been proposed for MM, even if MM CSCs have not been define yet. The existence of myeloma CSCs with clonotypic B and clonotypic non B cells was postulated by many groups. This review aims to focus on these distinct clonotypic subpopulations and on their ability to develop and sustain MM. The bone marrow microenvironment provides to MM CSCs self-renewal, survival and drug resistance thanks to the presence of normal and cancer stem cell niches. The niches and CSCs interact each other through adhesion molecules and the interplay between ligands and receptors activate stemness signaling(Hedgehog, Wnt and Notch pathways). MM CSCs are also supposed to be responsible for drug resistance that happens in three steps from the initial cancer cell homing microenvironment-mediated to development of microenvironment-independent drug resistance. In this review, we will underline all these aspects of MM CSCs. | Ilaria Saltarella Aurelia Lamanuzzi Antonia Reale Angelo Vacca Roberto Ria | 2015 | World Journal of Stem Cells2015，7，1： | 4 |
| 4 | A new algorithm for bank-failure mechanisms in 2D morphodynamic models with unstructured grids显示文摘河岸失败是在似地球形状的过程的重要现象。面对河岸或陡峭的 bedforms,水级的上升深深地导致的倒塌机制与沉积运输过程一起影响床进化。在这份报纸,能够在一个二维的二阶段的 morphodynamic 模型模仿如此的机制的一个算法被介绍。混合的 A 以房间为中心、以节点为中心的有限卷的 discretization,使用一个未组织的三角形的网孔并且在只有一个意义地要定义的每个房间允许斜坡,被建议。geo 失败操作员保证当在房间床斜坡超过一个批评角度时,相应的床材料和毛孔水将成为床运输的部分并且然后将跟随二阶段的流动的动态方程。算法有效性被一些试验性的测试的数字繁殖从文学显示出。 | Stefania Evangelista Massimo Greco Michele Iervolino Angelo Leopardi Andrea Vacca | 2015 | International Journal of Sediment Research2015，30，4： | 4 |
| 5 | High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma显示文摘 | Franca Falzetti Mauro Ianni Stelvio Ballanti Giuseppe Iodice Antonia Reale Olivia Minelli Gabriella Serio Massimo Martelli Franco Dammacco Angelo Vacca Roberto Ria | 2012 | Clinical and Experimental Medicine2012，，3： | 1 |
| 6 | The role of microenvironment in tumor angiogenesis显示文摘 | Domenico Ribatti Angelo Vacca | 2008 | Genes & Nutrition2008，，1： | 1 |
| 7 | Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO显示文摘Innate responses combine with adaptive immunity to generate the most effective form of anti-Aspergillus immune resistance.Whereas the pivotal role of dendritic cells in determining the balance between immunopathology and protective immunity to the fungus is well established,we determined that epithelial cells(ECs)also contributes to this balance.Mechanistically,EC-mediated protection occurred through a Toll-like receptor 3/Toll/IL-1 receptor domain-containing adaptor-inducing interferon(TLR3/TRIF)-dependent pathway converging on indoleamine 2,3-dioxygenase(IDO)via non-canonical nuclear factor-kB activation.Consistent with the high susceptibility of TRIF-deficient mice to pulmonary aspergillosis,bone marrow chimeric mice with TRIF unresponsive ECs exhibited higher fungal burdens and inflammatory pathology than control mice,underexpressed the IDO-dependent T helper 1/regulatory T cell(Th1/Treg)pathway and overexpressed the Th17 pathway with massive neutrophilic inflammation in the lungs.Further studies with interferon(IFN)-c,IDO or IL-17R unresponsive cells confirmed the dependency of immune tolerance to the fungus on the IFN-c/IDO/Treg pathway and of immune resistance on the MyD88 pathway controlling the fungal growth.Thus,distinct immune pathways contribute to resistance and tolerance to the fungus,to which the hematopoietic/non-hematopoietic compartments contribute through distinct,yet complementary,roles. | Antonella de Luca Silvia Bozza Teresa Zelante Silvia Zagarella Carmen D’Angelo Katia Perruccio Carmine Vacca Agostinho Carvalho Cristina Cunha Franco Aversa Luigina Romani | 2010 | Cellular & Molecular Immunology2010，7，6： | 1 |
| 8 | The role of microenvironment in tumor angiogenesis显示文摘 | Domenico Ribatti Angelo Vacca | 2008 | Genes & Nutrition2008，，1： | 1 |
| 9 | Chronic inflammation enhances NGF-β/TrkA system expression via EGFR/MEK/ERK pathway activation in Sj?gren’s syndrome显示文摘 | Sabrina Lisi Margherita Sisto Domenico Ribatti Massimo D’Amore Raffella Lucro Maria Antonia Frassanito Loredana Lorusso Angelo Vacca Dario Domenico Lofrumento | 2014 | Journal of Molecular Medicine2014，，： | 1 |
| 10 | A two-phase model for fast geomorphic shallow flows显示文摘纸介绍 2D 浅水模型基于为快似地球形状的 transients 的分析的二阶段的明确的表达发生在河 morphodynamics 的上下文。质量和动量保存原则独立为两个阶段被强加。模型自然地说明非平衡固体运输,自从两个即时改编假设也不任何东西落后方程被采用代表沉积动力学。建议模型的夸张特性被显示在流动条件上独立地被保存。从 1D 和 2D 测试用例的数字模拟的结果与文学相比试验性的数据并且与可得到的数字解决方案。 | Massimo GRECO Michele IERVOLINO Angelo LEOPARDI Andrea VACCA | 2012 | International Journal of Sediment Research2012，27，4： | 0 |
| 11 | The bone marrow niche landscape:a journey through aging,extrinsic and intrinsic stressors in the haemopoietic milieu显示文摘Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems,thought to properly sustain blood cell production and distinguish between friend and foe,can actively sustain a corrupted neighborhood within a chronic aberrant inflamed state.The bone marrow niche hijacks the physiologic hematopoiesis.The interactions between the hematopoietic stem cells and the niche in the bone marrow are critical determinants of quiescence.We examined several approaches to confront the available evidence;three key points emerged,pointing to the chronic inflammation process,especially the chronic infection and systemic inflammatory states,as leading causes of hematopoietic stem cell depletion.Clonal hematopoiesis,defined as a relative expansion of individual clones,is caused by somatic alterations in essential hematopoietic genes,which increase stem cell fitness.Moreover,terminal differentiation plays a significant role in progenitor loss and inflammatory signaling,promoting clonal selection and clonal hematopoiesis conditions.Specific myeloid malignancies as paradigmatic examples are discussed as a condition associated with inflammation,including the 5q-syndrome,Philadelphia negative myeloproliferative neoplasms,and chronic myeloid leukemia.Aging with increased fitness and hematopoietic stem cell attrition,extrinsic stress,enhanced stressor-specific fitness,and intrinsic defect across the hematopoietic process represent the route for novel insights in defective hematopoiesis.The discussion in this review also points out that the hematopoietic niches’inflammatory stimulation may affect differentiation patterns and the function of downstream cells. | Antonio Giovanni Solimando Assunta Melaccio Angelo Vacca Roberto Ria | 2022 | Journal of Cancer Metastasis and Treatment2022，8，1： | 0 |
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