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| 1 | Involvement of sweet pepper Ca LOX2 in jasmonate-dependent induced defence against Western flower thrips显示文摘Insect herbivory can seriously hinder plant performance and reduce crop yield. Thrips are minute cell-content-feeding insects that are important vectors of viral plant pathogens, and are serious crop pests. We investigated the role of a sweet pepper (Capsicum annuum) lipoxygenase gene, CaLOX2, in the defense of pepper plants against Western flower thrips (Frankliniella occidentalis). This was done through a combination of in-silico, transcrip-tional, behavioral andchemicalanalyses.Our datashowthat CaLOX2 is involved in jasmonic acid (JA) biosynthesis and mediates plant resistance. Expression of the JA-related marker genes, CaLOX2 and CaPIN II, was induced by thrips feeding. Silencing of CaLOX2 in pepper plants through virus-induced gene silencing (VIGS) resulted in low levels of CaLOX2 transcripts, as well as significant reduction in the accumulation of JA, and its derivatives, upon thrips feeding compared to control plants. CaLOX2-silenced pepper plants exhibited enhanced susceptibility to thrips. This indicates that CaLOX2 mediates JA-dependent signaling, resulting in defenseagainstthrips. Furthermore,exogenous application of JA to pepper plants increased plant resistance to thrips, constrained thrips population development and made plants less attractive to thrips. Thus, a multidisciplinary approach shows that an intact lipoxygenase pathway mediates various components of sweet pepper defense against F. occidentalis. | Sandeep J Sarde Klaas Bouwmeester Jhon Venegas-Molina Anja David Wilhelm Boland Marcel Dicke | 2019 | Journal of Integrative Plant Biology2019，61，10： | 6 |
| 2 | Valproic acid and nonalcoholic fatty liver disease: A possible association?显示文摘Valproic acid(VPA) is one of the most prescribed drugs in children with newly diagnosed epilepsy. Weight gain and obesity have been observed as side effects of VPA. These are often linked with other metabolic disturbances such as development of insulin resistance, dyslipidemia, metabolic syndrome(Met S) and nonalcoholic fatty liver disease or nonalcoholic fatty liver disease(NAFLD). NAFLD refers to a group of liver disorders with marked hepatic steatosis. It is associated with an increased incidence of cardiovascular diseases and overall reduced life expectancy. NAFLD occurs in 20%-25% of the general population and it is known to be the most common cause of chronic liver disease. NAFLD therefore represents a major public health issue worldwide. This study reviews and summarizes relevant literature that supports the existence of an association between VPA therapy and the development of NAFLD in children. Long-term VPA-therapy appears to be associated with an increased risk of developing NAFLD. Further studies are needed to clarify the pathogenic mechanisms that lie behind this association and to standardize the options for the use of this drug in overweight patients and in those with risks for developing Met S and NAFLD. | Edoardo Farinelli David Giampaoli Anja Cenciarini Ephraim Cercado Alberto Verrotti | 2015 | World Journal of Hepatology2015，7，9： | 3 |
| 3 | Efficacy and tolerability of vildagliptin monotherapy in drug-na?ve patients with type 2 diabetes显示文摘 | F. Xavier Pi-Sunyer Anja Schweizer David Mills Sylvie Dejager | 2007 | Diabetes Research and Clinical Practice2007，，1： | 2 |
| 4 | Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes显示文摘 | Bo Ahrén Mona Landin-Olsson Per-Anders Jansson Maria Svensson David Holmes Anja Schweizer | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，5： | 2 |
| 5 | Review of fuel oil quality and combustion of fast pyrolysis bio-oils from lignocellulosic biomass显示文摘 | Jani Lehto Anja Oasmaa Yrj? Solantausta Matti Kyt? David Chiaramonti | 2014 | Applied Energy2014，，： | 1 |
| 6 | Power generation using fast pyrolysis liquids from biomass 显示文摘 | DAVID C ANJA O YRJO S | 2005 | Renewable and Sustainable Energy Reviews2005，，11： | 1 |
| 7 | Evidence for Behavioral Attractiveness of Methoxylated Aromatics in a Dynastid Scarab Beetle-Pollinated Araceae显示文摘 | Stefan D?tterl Anja David Wilhelm Boland Ilse Silberbauer-Gottsberger Gerhard Gottsberger | 2012 | Journal of Chemical Ecology2012，，12： | 1 |
| 8 | Association between pneumococcal load and disease severity in adults with pneumonia显示文摘 | Anja MW Trevor PA David RM | 2012 | J Med Microbiol2012，61，： | 1 |
| 9 | Power generation using fast pyrolysis liquids from biomass 显示文摘 | DAVID CHIARAMONTI ANJA OASMAA YRJO SO- LANTAUSTA | 2007 | Renewable and Sustainable Energy Reviews2007，11，6： | 1 |
| 10 | Power generation using fast pyrolysis liquids from biomass显示文摘 | DAVID CHIARAMONTI ANJA OASMAA | 2007 | Renewable and sustainable energy reviews2007，11，： | 1 |
| 11 | 3D printing of patient-specific implants for osteochondral defects: workflow for an MRI-guided zonal design显示文摘Magnetic resonance imaging(MRI)is a common clinical practice to visualize defects and to distinguish different tissue types and pathologies in the human body.So far,MRI data have not been used to model and generate a patient-specific design of multilayered tissue substitutes in the case of interfacial defects.For orthopedic cases that require highly individual surgical treatment,implant fabrication by additive manufacturing holds great potential.Extrusion-based techniques like 3D plot-ting allow the spatially defined application of several materials,as well as implementation of bioprinting strategies.With the example of a typical multi-zonal osteochondral defect in an osteochondritis dissecans(OCD)patient,this study aimed to close the technological gap between MRI analysis and the additive manufacturing process of an implant based on dif-ferent biomaterial inks.A workflow was developed which covers the processing steps of MRI-based defect identification,segmentation,modeling,implant design adjustment,and implant generation.A model implant was fabricated based on two biomaterial inks with clinically relevant properties that would allow for bioprinting,the direct embedding of a patient’s own cells in the printing process.As demonstrated by the geometric compatibility of the designed and fabricated model implant in a stereolithography(SLA)model of lesioned femoral condyles,a novel versatile CAD/CAM workflow was successfully established that opens up new perspectives for the treatment of multi-zonal(osteochondral)defects. | David Kilian Philipp Sembdner Henriette Bretschneider Tilman Ahlfeld Lydia Mika Jörg Lützner Stefan Holtzhausen Anja Lode Ralph Stelzer Michael Gelinsky | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
| 12 | EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer显示文摘 | Christiane Daniela Fichter Sylvia Timme Julia Alexandra Braun Verena Gudernatsch Anja Sch?pflin Lioudmilla Bogatyreva Helene Geddert Gerhard Faller David Klimstra Laura Tang Dieter Hauschke Martin Werner Silke Lassmann | 2014 | Int J Cancer2014，，7： | 1 |
| 13 | Power generation using fast pyrolysis liquids from biomass显示文摘 | David Chiaramonti Anja Oasmaa Yrjo Solantausta | 2007 | Renewable and sustainable energy reviews2007，11，： | 1 |
| 14 | Oxidized LDL cholesterol induces endothelial dysfunction in the aorta and Lox-1 expression in macrophages 显示文摘 | Anja L David M P Robert A | 2012 | Arterioscler Thromb Vasc Biol2012，32，5： | 1 |
| 15 | Power generation using fastpyrolysis liquids from biomass显示文摘 | David Chiaramonti Anja Oasmaa Yrjo Solantausta | 2005 | Renewable and Sustainable Energy Reviews2005，，11： | 1 |
| 16 | Failure of a T cell regulator: CD6 contributes to the aggravation of autoimmune inflammation显示文摘The scavenger-like lymphocyte receptor CD6 is a regulator of T cell functions,and is associated with autoimmune diseases.However,the specific contribution of CD6 to autoimmunity remains unknown.Under physiological conditions,CD6 associates with the T cell antigen receptor(TCR)/CD3 complex at the center of the immunological synapse and regulates T cell responses through activation-dependent recruitment of the positive regulator SLP-76 and other downstream signaling effectors.1,2 In recent years,immune-activating and immune-inhibiting functions of CD6 have been reported,indicating a dual role of CD6 in T cell activation.1 It has been postulated that the strength of TCR activation determines whether CD6 enhances or inhibits TCR signaling.1 This possible counter-regulatory role of CD6 may contribute to the control of T cell responses. | Anja Meyer David M.Kofler | 2019 | Cellular & Molecular Immunology2019，16，9： | 1 |
| 17 | Cooling of photovoltaic cells under concentrated illmnination:a critical review显示文摘 | Royne Anja Dey Christopher J Mills David R | 2005 | Solar Energy Materials & Solar Cells2005，，86： | 1 |
| 18 | The HvNAC6 transcription factor: a positive regulator of penetration resistance in barley and Arabidopsis显示文摘 | Michael Krogh Jensen Jesper Henrik Rung Per Langkjaer Gregersen Torben Gjetting Anja Thoe Fuglsang Michael Hansen Nina Joehnk Michael Foged Lyngkjaer David B. Collinge | 2007 | Plant Molecular Biology (-)2007，，1： | 1 |
| 19 | Cooling of Photovoltaie Cells Under Concentrated Illumination: A Critical Review显示文摘 | Anja Royne Christopher Dey J David Mills R | 2005 | Solar Energy Materials & Solar Cells2005，，86： | 1 |
| 20 | Cooling of photovoltaic cells under concentrated illumination: a critical review显示文摘 | Anja Royne Dey Christopher J Mills David R | 2005 | Solar Energy Materials & Solar Cells2005，，86： | 1 |
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