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| 1 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 2 | Single-cell transcriptomes and runx2b^(-/-)mutants reveal the genetic signatures of intermuscular bone formation in zebrafish显示文摘Intermuscular bones(IBs)are mineralized spicules,present in the myosepta of many,but not all,teleost species.IBs are often small and sharp,and they consequently limit how the fish can be processed;the IBs may cause injury or trauma if lodged in consumers’throats or mouths,and therefore affect the appeal of the fish to many consumers.The development of IBs in teleosts is still not fully understood and the molecular basis of IB development remains to be established.Here,the characteristics of IB tissue are evaluated based on single-cell transcriptomics in wild-type zebrafish.The analysis defined 18 distinct cell types.Differentiation trajectories showed that IBs are derived from tendons and that a core tendon-osteoblast cell lineage is related to IB formation.In particular,the functions of 10 candidate genes were evaluated via CRISPR-Cas9 mutants.Among those,runx2b^(-/-)mutants completely lost IBs,while swimming performance,growth and bone mineral density were not significantly different from runx2b^(+/+)zebrafish.Comparative single-cell RNA sequencing(sc RNA-seq)analysis in runx2b^(-/-)and runx2b^(+/+)zebrafish revealed the role of osteoblasts in IB formation.In addition,differentially expressed genes were enriched in the transforming growth factorβ/bone morphogenetic protein(TGF-β/BMP)pathway after runx2b deletion.This study provides evidence for the crucial role of runx2b regulation in IB formation.Genetic breeding can target runx2b regulation and generate strains of commercial fish species without IBs,which can improve the safe consumption and economic value of many farmed fish species. | Chun-Hong Nie Shi-Ming Wan Yu-Long Chen Ann Huysseune Ya-Ming Wu Jia-Jia Zhou Alexandre Wagner Silva Hilsdorf Wei-Min Wang Paul Eckhard Witten Qiang Lin Ze-Xia Gao | 2022 | National Science Review2022，9，11： | 6 |
| 3 | (La0.8A0.2)MnO3(A=Sr,K) perovskite catalysts for NO and C10H22 oxidation and selective reduction of NO by C(10)H(22)显示文摘In this work, we studied the catalytic activity of LaMnO3 and(La0.8A0.2)MnO3(A = Sr, K) perovskite catalysts for oxidation of NO and C10H22 and selective reduction of NO by C10H22. The catalytic per‐formances of these perovskites were compared with that of a 2 wt% Pt/SiO2 catalyst. The La site substitution increased the catalytic properties for NO or C10H22 oxidation compared with the non‐substituted LaMnO3 sample. For the most efficient perovskite catalyst,(La0.8Sr0.2)MnO3, the results showed the presence of two temperature domains for NO adsorption:(1) a domain corre‐sponding to weakly adsorbed NO, desorbing at temperatures lower than 270 °C and(2) a second domain corresponding to NO adsorbed on the surface as nitrate species, desorbing at temperatures higher than 330 °C. For the Sr‐substituted perovskite, the maximum NO2 yield of 80% was observed in the intermediate temperature domain (around 285 °C). In the reactant mixture of NO/C10H22/O2/H2O/He,(La0.8Sr0.2)MnO3 perovskite showed better performance than the 2 wt% Pt/SiO2 catalyst: NO2 yields reaching 50% and 36% at 290 and 370 °C, respectively. This activity improvement was found to be because of atomic scale interactions between the A and B active sites, Sr2+ cation and Mn4+/Mn3+ redox couple. Thus,(La0.8Sr0.2)MnO3 perovskite could be an alternative free noble metal catalyst for exhaust gas after treatment. | Anne Giroir-Fendler Sonia Gil Alexandre Baylet | 2014 | 催化学报2014，35，8： | 4 |
| 4 | Effect of micro-algae Schizochytrium sp.supplementation in plant diet on reproduction of female rainbow trout(Oncorhynchus mykiss):maternal programming impact of progeny显示文摘Background:The broodstock diet,and in particular the lipid and fatty acid composition of the diet,is known to play a key role in reproductive efficiency and survival of the progeny in fish.A major problem when replacing both fish meal and fish oil by plant sources is the lack of n-3 long chain polyunsaturated fatty acids,such as eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA).To address this problem,we studied the effect of the plant-based diet supplemented with Schizochytrium sp.microalgae,source of DHA,compared to a conventional commercial diet rich in fish meal and fish oil on reproductive performance and egg quality and the consequences on progeny,in female rainbow trout broodstock.Results:The results demonstrated that DHA-rich microalgae supplementation in a plant-based diet allowed for the maintenance of reproductive performance and egg quality comparable to a conventional commercial feed rich in fish meal and fish oil and led to an increased significant fry survival after resorption.Moreover,when females were fed a plant-based diet supplemented with micro-algae,the 4-month-old progenies showed a significant higher growth when they were challenged with a similar diet as broodstock during 1 month.We provide evidence for metabolic programming in which the maternal dietary induced significant protracted effects on lipid metabolism of progeny.Conclusions:The present study demonstrates that supplementation of a plant-based diet with DHA-rich microalgae can be an effective alternative to fish meal and fish oil in rainbow trout broodstock aquafeed. | Emilie Cardona Emilien Segret Yoann Cachelou Thibaut Vanderesse Laurence Larroquet Alexandre Hermann Anne Surget Geneviève Corraze Frederic Cachelou Julien Bobe Sandrine Skiba-Cassy | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 1 |
| 5 | Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy显示文摘 | Sébastien Gaujoux Alexandre Cortes Anne Couvelard Séverine Noullet Laurent Clavel Vinciane Rebours Philippe Lévy Alain Sauvanet Philippe Ruszniewski Jacques Belghiti | 2010 | Surgery2010，，1： | 1 |
| 6 | Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages显示文摘 | Cédric Rébé Magalie Raveneau Angélique Chevriaux Daniela Lakomy Anne-Laure Sberna Annie Costa Ginette Bessède Anne Athias Eric Steinmetz Jean Marc A. Lobaccaro Georges Alves Alexandre Menicacci Sébastien Vachenc Eric Solary Philippe Gambert David Masson | 2009 | Circulation Research2009，，4： | 1 |
| 7 | SSR mining in coffee tree EST databases: potential use of EST–SSRs as markers for the Coffea genus显示文摘 | Valérie Poncet Myriam Rondeau Christine Tranchant Anne Cayrel Serge Hamon Alexandre Kochko Perla Hamon | 2006 | Molecular Genetics and Genomics2006，，5： | 1 |
| 8 | Contribution of Phytoliths to the Suspended Load of Biogenic Silica in the Nyong Basin Rivers (Cameroon) 显示文摘 | Lise Cary Anne Alexandre Jean-dominique Meunier | 2005 | Biogeochemistry2005，74，： | 1 |
| 9 | Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional results显示文摘 | Alexandre Bozec Gilles Poissonnet Emmanuel Chamorey Claire Laout Jacques Vallicioni Fran? ois Demard Fré dé ric Peyrade Philippe Follana René -Jean Bensadoun Karen Benezery Juliette Thariat Pierre-Yves Marcy Anne Sudaka Olivier Dassonville | 2009 | Acta Oto-Laryngologica2009，，6： | 1 |
| 10 | Involve-ment of the phospholipid sterol acyltransferase1in plant sterol homeostasis and leaf senescence显示文摘 | PIERRETTE B ANN B ALEXANDRE N | 2010 | Plant Physiol2010，152，1： | 1 |
| 11 | Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis显示文摘 | Philippe Metellus Bema Coulibaly Carole Colin Andre Maues Paula Alexandre Vasiljevic David Taieb Anne Barlier Blandine Boisselier Karima Mokhtari Xiao Wei Wang Anderson Loundou Frederique Chapon Sandrine Pineau L’Houcine Ouafik Olivier Chinot Dominique Fi | 2010 | Acta Neuropathologica2010，，6： | 1 |
| 12 | Inactivation of plant pectin methylesterase by thermal or high intensity pulsed electric field treatments 显示文摘 | ALEXANDRE ESPACHS-BARRGSO ANN VAN LOEY MARC HENDRICKX | 2006 | Innovative Food Science and Emerging Technologies2006，7，12： | 1 |
| 13 | Immune response to baculovirus expressed protein fragment amino acids 190 -289 of respiratory syncytial virus (RSV) fusion protein 显示文摘 | Bettina Werle Catherine Bourgeois Anne Alexandre | 1998 | Vaccine1998，16，： | 1 |
| 14 | Molecular phylogeny of the tribe Bovini (Bovidae, Bovinae) and the taxonomic status of the Kouprey, Bos sauveli Urbain 1937显示文摘 | Alexandre Hassanin Anne Ropiquet | 2004 | Molecular Phylogenetics and Evolution2004，，3： | 1 |
| 15 | Modification of Campylobacterjejuni Broiler Colonization by a Feed Additive Composed of Encapsulated Organic Acids and Essential Oils显示文摘 | Alexandre Thibodeau Philippe Fravalo Robert Gauthier Evelyne Guevremont Nadia Bergeron Sylvette Laurent-Lewandowski Sylvaln Quessy Martine Boulianne Ann Letellier | 2014 | Journal of Agricultural Science and Technology(A)2014，4，10： | 0 |
| 16 | 红色激情 法国La Hague文化中心显示文摘La Hague文化中心位于法国科唐坦半岛的博蒙阿盖海牙。这是一片拥有优质景观资源的区域,而文化中心的建成不但使建筑与环境相互融合,更起到相得益彰的作用。在半岛的岸边,下沉的道路两旁种植着繁茂的树木,在形成巨大防风带的同时,也抵挡着夏日阳光的猛烈照射。透过树叶的间隙,日光柔和地洒落在地面上,形成斑驳闪烁的光影。这些景观元素不仅构成了当地特殊的地域文化,同时也成为启发设计师灵感的源泉。 | 小麦(编译) Charlotte Letebvre Anne Clerget Emily Murphy Alfredo Luvison Camille Isaac-DogninGabriele Motta Anatole Jeannot Kirsten Elliot Thomas Dantec Yann Peter Alexandre Pascal Mehrnoush Naraghi Estelle Grange-Dubelle Sergio GRAZIA(摄影) 无 | 2016 | 室内设计与装修2016，0，9： | 0 |
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