| 1 | Different levels of facial expression recognition in patients with firstepisode schizophrenia:A functional MRI study显示文摘Background The impairment of facial expression recognition has become a biomarker for early identification of first-episode schizophrenia, and this kind of research is increasing.Aims To explore the differences in brain area activation using different degrees of disgusted facial expression recognition in antipsychotic-na?ve patients with firstepisode schizophrenia and healthy controls.Methods In this study, facial expression recognition tests were performed on 30 first-episode, antipsychoticna?ve patients with schizophrenia(treatment group) and 30 healthy subjects(control group) with matched age, educational attainment and gender. Functional MRI was used for comparing the differences of the brain areas of activation between the two groups.Results The average response time difference between the patient group and the control group in the ‘high degree of disgust' facial expression recognition task was statistically significant(1.359(0.408)/2.193(0.625), F=26.65, p<0.001), and the correct recognition rate of the treatment group was lower than that of the control group(41.05(22.25)/59.84(13.91, F=19.81, p<0.001). Compared with the control group, the left thalamus, right lingual gyrus and right middle temporal gyrus were negatively activated in the patients with first-episode schizophrenia in the ‘high degree of disgust' emotion recognition, and there was a significant activation in the left and right middle temporal gyrus and the right caudate nucleus. However, there was no significant activation difference in the ‘low degree of disgust' recognition.Conclusions In patients with first-episode schizophrenia, the areas of facial recognition impairment are significantly different in different degrees of disgust facial expression recognition. | Chengqing Yang Ansi Qi Huangfang Yu Xiaofeng Guan Jijun Wang Na Liu Tianhong Zhang Hui Li Hui Zhou Junjuan Zhu Nan Huang Yingying Tang Zheng Lu | 2018 | General Psychiatry2018，31，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员