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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | Efficient 3D modeling of vibration isolation by open trenches显示文摘 | Klein R Antes H LeHouedec D | 1997 | Computers and Structures1997，64，： | 1 |
| 5 | Detection of Paenibacillus larvae subspecies larvae spores in naturally infected bee larvae and artificially contaminated honey by PCR显示文摘 | Claudia Piccini Bruno D’Alessandro Karina Antúnez Pablo Zunino | 2002 | World Journal of Microbiology and Biotechnology2002，，8： | 1 |
| 6 | Efficient 3D modelling of vibration isolation by open trenches显示文摘 | Klein R Antes H Le Houedec D | 1997 | Computers and Structures1997，64，1： | 1 |
| 7 | An optimization of the Wa-telowscore using regression and artificial neural net works显示文摘 | Ant hony D Clark M Darllender J | 2004 | Cline Rehabil2004，14，1： | 1 |
| 8 | Improving the performance of passive network monitoring applications with memory locality enhancements 显示文摘 | PAPADOGIANNAKIS A VASILIADIS G ANT()- NIADES D | 2012 | Computer Communica- tions2012，35，1： | 1 |
| 9 | 显示文摘 | Reynolds D C Leies G Antes L T | 1954 | PhysRev1954，96，： | 1 |
| 10 | Species,roasting degree and decaffeination influence the antibacterial activity of coffee against Streptococcus mutans显示文摘 | Ant?nioA G Moraes R S Perrone D | 2010 | Food Chemistry2010，118，3： | 1 |
| 11 | AI203/Ti interlayer/M- S1304 diffusion bonded joint: mierostnietural characterization of the two interlaces显示文摘 | Kliauga A M Travessa D Fen'ante M | 2001 | Materials Characterization2001，46，1： | 1 |
| 12 | Comparative genomies of MAP kinase and calcium calcineurin signaling components in plant and human pathogenic fungi 显示文摘 | Rispail N Soanes D M Ant C et cd | 2009 | Fung Genet Biol2009，46，2： | 1 |
| 13 | Radiofrequency thermal ablation versus other interventions for hepatocellular carcinoma显示文摘 | Galandi D Antes G | 2004 | Cochrane Database Syst Rev2004，，00： | 1 |
| 14 | Identification of a mi- croRNA panel for clear-cell kidney cancer 显示文摘 | Juan D Alexe G Antes T | 2010 | Urology2010，75，： | 1 |
| 15 | Pulmonaryem-bolism and sibilant types of chronic obstructive pulmonary disease decompensations显示文摘 | Mispelaere D Gler ant JC Audebert M | 2002 | Rev Mal Respir2002，19，4： | 1 |
| 16 | Efficient 3D modelling of vibration isolation by open trenches显示文摘 | Klein R Antes H Le Houedec D | 1997 | Computers and Structures1997，64，1： | 1 |
| 17 | Efficient 3D modelling of vibration isolation by open trenches显示文摘 | KLEIN R ANTES H LE Houédec D L | 1997 | Computers and Structures1997，64，： | 1 |
| 18 | Recognition of Coloured and Textured Images through a Multi-Scale Neural Architecture with Orientational Filtering and Chromatic Diffusion显示文摘 | Antón-Rodríguez M Díaz-Pernas F J Díez-Higuera J F | | 0，，16： | 1 |
| 19 | Identification of a microRNA panel for clear-cell kidney cancer显示文摘 | Juan D Alexe G Antes T | 2010 | Urology2010，75，4： | 1 |
| 20 | System concept and implementation of a mm W wireless link providing data rates up to 25 Gbit/s显示文摘 | J Antes J Reicharty D Lopez-Diaz | 2013 | Electronics Letters2013，46，9： | 1 |
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