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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 3 | Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity显示文摘 | Nimmerjahn F Anthony R M Ravetch J V | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 4 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 5 | Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis) bulbs显示文摘 | Dammea E J M V Anthony K A Willy P J | 1987 | FEBS Lett1987，，215： | 1 |
| 6 | En-hancement of Indirect Sulphation of Limestone by SteamAddition显示文摘 | Stewart M C Manovic V Anthony E J | 2011 | Environmental Science ^Technology2011，44，22： | 1 |
| 7 | Spontaneous phasic activity of the pig urinary bladder smooth muscle 显示文摘 | Steven A B Ivan M Anthony V D | 2002 | British Journal of Pharmacology2002，135，： | 1 |
| 8 | Foreign Direct Investment as a Catalyst for industrial Development显示文摘 | ANTHONY J V | 1999 | European Eoonomic Review1999，43，： | 1 |
| 9 | A preliminary molecular analysis of phylogenetic relationships of australasian wolf spider genera (Araneae, Lycosidae)显示文摘 | Cor J V Anthony D M Adrian M P | 2002 | J Arachnol2002，30，2： | 1 |
| 10 | Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content显示文摘 | Ann M Poynten Seng Khee Gan Adamandia D Kriketos Anthony O'Sullivan John J Kelly Bronwyn A Ellis Donald J Chisholm Lesley V Campbell | 2003 | Metabolism2003，，6： | 1 |
| 11 | Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm显示文摘 | Imakawa K Anthony R V Kazemi M | 1987 | Nature1987，330，6146： | 1 |
| 12 | Classification of toxin-induced changes in 1H NMR spectra of urine u- sing an artificial neural network 显示文摘 | ANTHONY M L ROSE V S NICHOLSON J K | 1995 | Journal of Pharmaceutical and Biomedical Analysis1995，13，3： | 1 |
| 13 | Indirect Health Effects of Relative Humidity in Indoor Environments显示文摘 | Anthony V Arundel Elia M Sterling Judith H Biggin | 1986 | Environment Health Perspectives1986，，65： | 1 |
| 14 | Rationale and perspectives on the development of fungicides 显示文摘 | Knight S C Anthony V M Brady A M | 1997 | Annual Review of Phytopathology1997，35，1： | 1 |
| 15 | Topotactic oxidation of TiGaPO-1, pyridine-templated titaniumgallophosphate with a new octahedral tetrahedral 3-D framework structure containing Ti^Ⅲ/Ti^Ⅳ 显示文摘 | Ann M C Mark R G Anthony V P | 2005 | Inorg Chem2005，44，： | 1 |
| 16 | Topotactic oxidation of TiGaPO-1,a pyridine-templated titanium gallophosphate with a new octahedral-tetrahedral3-D framework structure containing Tim/Tin显示文摘 | Chippindale Ann M Grimshaw Mark R Powell Anthony V | 2005 | Inorganic Chemistry2005，44，： | 1 |
| 17 | Bats are a major natural reservoir for hepaeiviruses and pegiviruses显示文摘 | Quan P L Firth C Conte J M Williams S H Zam- brana-Torrelio C M Anthony S J Ellison J A Gilbert A T Kuzmin I V Niezgoda M Osinubi M O Re-cuenco S Markotter W Breiman R F Kalemba L Malekani J Lindblade K A Rostal M K Ojeda-Flores R Suzan G Davis L B Blau D M Ogunkoya A B Alvarez Castillo D A Moran D Ngam S Akaibe D Agwanda B Briese T Epstein J H Daszak P Rup- precht C E Holmes E C Lipkin W I | 2013 | PNAS2013，110，20： | 1 |
| 18 | Placental cord insertion and birth weight discordancy in twin gestations显示文摘 | Maryellen L Hanley Cande V Ananth Susan Shen-Schwarz John C Smulian Yu-Ling Lai Anthony M Vintzileos | 2002 | Obstetrics & Gynecology2002，，3： | 1 |
| 19 | Indirect health effects of relative humidity in indoor environment显示文摘 | Arundel Anthony V Sterling Elia M Biggin Judith H | 1986 | Environmental Health Perspectives1986，65，： | 1 |
| 20 | Enhancement of indirect sulphation of limestone by steam addition显示文摘 | Stewart M C Manovic V Anthony E J | | 0，，22： | 1 |
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