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| 1 | Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi显示文摘在植物,到 necrotrophic 病原体的抵抗取决于在不同荷尔蒙系统之间的相互影响,例如水杨酸调整的那些酸(SA ) , jasmonic 酸(JA ) ,乙烯,和 abscisic 酸。由 SA 小径发信号的植物生长素的压抑最近被显示贡献抗菌剂抵抗。这里,我们表明表明在刺激植物生长素的 SCF (Skp1CullinF 盒子) ubiquitination 小径展览有缺点的异种 axr1, axr2,和 axr6 的那 Arabidopsis 植物生长素增加的危险性到 necrotrophic 真菌 Plectosphaerella cucumerina 和 Botrytis cinerea。另外,被 SCF-ubiquitin/proteasome 机械通常为移动指向的植物生长素 transcriptional 抑压者 AXR3 的稳定发生在 P 之上。cucumerina 感染。植物生长素运输或 proteasome 功能的药理学抑制各作为在非对待的植物生长素反应异种损害野类型的植物的 necrotroph 抵抗到类似的程度。这些结果建议植物生长素发信号为到 necrotrophic 真菌 P 的抵抗是重要的。cucumerina 和 B。cinerea。SGT1b (编码 HSP90/HSC70 合作女伴的二 Arabidopsis SGT1 基因之一) 在某些抵抗(R) 基因调节到 biotrophic 病原体的植物生长素和 JA 回答和抵抗支持 SCF E3-ubiquitin ligase 建筑群的功能。我们发现 sgt1b 异种对 P 同样抵抗。是的 cucumerina 野类型的植物。相反地, auxin/SCF 发信号异种在到 obligate biotrophic oomycete 的被触发 RPP4 的抵抗是不妥协的, Hyaloperonospora parasitica。因此,在到 oomycetes 的 R 调节基因的抵抗的 SGT1b 的占优势的行动看起来在除帮助 SCF E3-ubiquitin ligases 以外的一个地点。然而, sgt1b axr1 的基因添加在到 H 的危险性的两倍异种。一旦 plantpathogen 相容性被建立, parasitica 建议调停 SCF 的 ubiquitination 贡献限制 biotrophic 病原体殖民。 | Francisco Llorente Paul M usksktt Andrea Sanchez-Vallet Gemma Lopez Brisa Ramos Clara Sanchez-Rodriguez Lucia Jorda Jane Parker Antonio Molina | 2008 | Molecular Plant2008，1，3： | 8 |
| 2 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 3 | Recent advances in bird sperm morphometric analysis and its role in male gamete characterization and reproduction technologies显示文摘通过精子竞争的 Postcopulatory 性选择可以是影响许多繁殖特点的重要进化力量,包括精子 morphometrics。象污染物质,杀虫剂,和气候变化那样的环境因素可以影响不同精子特点,并且这样复制,在里面敏感的鸟种类。在帮助繁殖技术使用的许多处理精子的过程可以也影响精子房间的尺寸。精子房间结构(特别头) 的精确地测量的尺寸能因此被用作环境影响的指示物,在改进我们繁殖、进化的策略的理解,并且为优化帮助了繁殖技术(例如,精子 cryopreservation ) 为有鸟的使用。帮助计算机的精子 morphometry 分析(CASA-Morph ) 为估计精子 morphometry 提供一个精确、可靠的方法,减少与人的视觉评价联系的主观的问题。计算机化的系统从不同哺乳动物的种类与精液为使用被标准化了。然而,鸟的精子是丝状的,限制他们有如此的系统的分析,它被开发检查哺乳动物的精子房间的近似球形的负责人。帮助克服这,染色技术在估计计算机的轻显微镜的方法被过去常的标准化是优先级。现在的评论讨论这些点并且描述几野生、国内的鸟种的精子 morphometric 特征。 | Julian Santiago-Moreno Milagros Cristina Esteso Silvia Villaverde-Morcillo Adolfo Toledano-Diaz Cristina Castafio Rosario Velazquez Antonio Lopez-Sebastian Agustin Lopez Goya Javier Gimeno Martinez | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 4 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 5 | High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula显示文摘to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice Age.These proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface wetness.Analysis:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[cal.yr BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier conditions.The Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet phases.The LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification index.However,four different climate phases were differentiated in this period.High-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global models.The study provides new information and a detailed chronology of climatic events that will help to refine local modulation of the climate evolution model in the still quite unexplored region of the NW Iberian Peninsula,a key area for understanding the paleoclimatic dynamics in SW Europe. | Daniel Castro Martin Souto Maria Isabel Fraga Eduardo Garcia-Rodeja Sebastian Perez-Diaz Jose Antonio Lopez Saez Xabier Pontevedra-Pombal | 2020 | Geoscience Frontiers2020，11，5： | 2 |
| 6 | Few-mode fibre-optic microwave photonic links显示文摘The fibre-optic microwave photonic link has become one of the basic building blocks for microwave photonics.Increasing the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic range.Even though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude lower.In this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial modes.Using specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed transmission.This work represents the first step in few-mode microwave photonics.The spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics. | He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose Enrique Antonio Lopez Rodrigo Amezcua Correa Guifang Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 7 | Mathematical Morphology Applied to Raster Generalization of Urban City Block Maps 显示文摘 | Manuel Antonio Urena Camara Francisco Javier Ariza Lopez | 2000 | Cartographica2000，37，1： | 1 |
| 8 | Peers' Influence On Exer- cise Enjoyment:A Self-determination Theory Approach 显示文摘 | Juan Antonio Moreno Murcia Maria Lopez de San Romfn Celestina Martinez Galindo Nestor Alonso David Gonzalez-Cutre | 2008 | Journal of Sports and Medicine2008，，1： | 1 |
| 9 | NMR characterization of carbon dioxide chemical absorption with monoethanolarnine, diethanolamine, and triethanolamine 显示文摘 | Alicia Garcia-Abuin Diego Gomez-Diaz Aria B Lopez Jose M Navaza Antonio Rumbo | 2013 | Industrial & Engineering Chemistry Research2013，52，13： | 1 |
| 10 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Antonio Lopez Michele Pagamo Angela Volpe Appio Claudio Dipinto | 2003 | Chemosphere2003，54，： | 1 |
| 11 | Very Low-Voltage Analog Processing Based on Quasi-Floating-Gate Transistors 显示文摘 | Angulo Jaime Ramirez Martin Antonio J Lopez Carajal Ramon G | 2004 | IEEE Journal of Solid-State Circutis2004，39，3： | 1 |
| 12 | Fenton's pretreatment of mature landfill leachate显示文摘 | Lopez Antonio | 2004 | Chemosphere2004，54，： | 1 |
| 13 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Antonio Lopez Michele Pagano Angela Volpe | 2004 | Chemosphere2004，54，7： | 1 |
| 14 | By-products formation during degradation of isoproturon in aqueous solution. II: chlorination显示文摘 | Giuseppe Mascolo Antonio Lopez Huw James Mike Fielding | 2001 | Water Research2001，，7： | 1 |
| 15 | The Origin of the Spinal Subdural Space:Ultrastructure Findings显示文摘 | Miguel Angel Reina MD Oscar De Leon Casasola MD Andres Lopez MD Jose Antonio De Andres MD Miguel Mora MD and Agustin Fernandez MD | 2002 | Anesth Analg2002，94，4： | 1 |
| 16 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Antonio Lopez Michele Pagano Angela Volpe Appio Claudio Di Pinto | 2003 | Chemosphere2003，54，： | 1 |
| 17 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Lopez Antonio Pagano Michele Volpe Angela | 2004 | Chemosphere2004，54，7： | 1 |
| 18 | Bacteriocin -based strategies for food biopreservation 显示文摘 | Antonio Galvez Hikmate Abriouel Rosario Lucas Lopez | 2007 | International Journal of Food Microbiology2007，120，12： | 1 |
| 19 | Bacteriocin -based strategies for tbod biopreservation 显示文摘 | Antonio Galvez Hikinate Abriouel Rosario Lucas Lopez | 2007 | International Journal of Food Microbiology2007，120，12： | 1 |
| 20 | Numerical Recognition of Unstrained Handwriting显示文摘 | Ernest Valeny Antonio Lopez | 2003 | IEEE2003，，： | 1 |
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