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| 1 | Regulatory T cells as a new therapeutic target for atherosclerosis显示文摘动脉粥样硬化是贡献 T 和 B 房间免疫者回答的过多的激活的 self-self-antigens 和 non-self-antigens 引起的自体免疫的疾病。这些回答进一步加重脉管的 infiammation 并且经由释放 pro-infiammatory cytokines 支持到匾的动脉粥样硬化和危险的前进。特别地,规章的 T 房间( Tregs )由压制象 T 和 B 房间,生来的杀手( NK )房间,单核白血球,和树枝状的房间( DC )那样的各种各样的房间的有免疫力的回答作为主要 immunoregulatory 房间导致并且维持有免疫力的动态平衡和忍耐,象由 secreting 一样处于生理、病理学的状态的禁止的 cytokines interleukin ( IL )-10, IL-35 和抄写生长因素(TGF-)。众多的证据证明 Treg 的减少的数字和机能障碍可以是在动脉粥样硬化致病的 involveved。增加或恢复并且改进 Tregs 的抑制免疫力的能力数字可以用作基本免疫疗法对待动脉粥样硬化患者心血管的疾病。在这篇文章,我们 briefiy 介绍 Treg 子集的当前的知识,总结在 Tregs 和动脉粥样硬化开发之间的关系,并且讨论调整为动脉粥样硬化致病和匾稳定性的改进的预防的 Tregs 的可能性。尽管对动脉粥样硬化的调停 Treg 的保护的准确分子的机制尚待被阐明,为指向 Tregs 的规定的策略可以为动脉粥样硬化患者的预防和治疗提供特定、重要的途径心血管的疾病。 | Han-xiao OU Bing-bing GUO Qi LIU Yu-kun LI Zhen YANG Wen-jie FENG Zhong-cheng MO | 2018 | Acta Pharmacologica Sinica2018，39，8： | 24 |
| 2 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 3 | Removal of heavy metals from sewage sludge by low costing chemical method and recycling in agriculture显示文摘RemovalofheavymetalsfromsewagesludgebylowcostingchemicalmethodandrecyclinginagricultureWuQitang,NyirandegePascasie,MoCehuiF... | Wu Qi tang, Nyirandege Pascasie, Mo Ce hui Faculty of Resources and Environments, South China Agricultural University, Guangzhou 510642, China Lin Yi Datansha Wastewater Treatment Plant, Guangzhou 510160, China | 1998 | Journal of Environmental Sciences1998，10，1： | 21 |
| 4 | Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of Solanum lyratum Thumb through the mitochondrial pathway显示文摘AIM To explore the induction effects and mechanism of Solanum lyratum Thumb(ST) on human hepatocellularcarcinoma SMMC-7721 cells through the mitochondrial pathway.METHODS The experiments were conducted on three groups: an experimental group (with ST ethanol extracts' concentration being 2.5, 5 and 10 mg/L), a negative control group (with only nutrient solution, 0 mg/L ST ethanol extracts), and a positive control group (2.5 mg/L DDP). The inhibition rate of cell proliferation was checked by using the methyl thiazolyl tetrazolium method, and cell apoptosis was tested by TUNEL method. Furthermore, RT-PCR was used to examine m RNA expression of Fas, Fas L, caspase-8, caspase-3, p53 and Bcl-2 genes.RESULTS Compared with the negative control group, the inhibition and apoptosis rates of the experimental group with different concentrations of ST extracts on human hepatocellular carcinoma SMMC-7721 cells significantly increased(P<0.05). Besides, the m RNA expression of Fas L and Bcl-2 significantly decreased(P<0.05) while the m RNA expression of Fas, caspase-8, caspase-3 and p53 increased significantly. When compared with the positive control group, the experimental groups with 5 mg/L ST ethanol extracts showed effects similar to the positive control group.CONCLUSION ST ethanol extracts induced the apoptosis of hepatocellular carcinoma SMMC-7721 cells through up-regulated Fas, caspase-8, caspse-3 and p53, and down-regulated Fas L and Bcl-2 in the mitochondrial pathway. | Xiao-Qiang Mo Hong-Yu Wei Gan-Rong Huang Ling-Yuan Xu Yu-Li Chen Jiang Qi Wei Xian Yan-Chun Qin Lian-Deng Wei Li-Juan Zhao Yan-Qiang Huang Wei Xing Hong-Qin Pu Peng-Ya Wei Chao-Gan Li Qiu-Chun Liang | 2017 | World Journal of Gastroenterology2017，23，6： | 14 |
| 5 | A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes显示文摘Thermal runaway has been a long-standing safety issue impeding the development of high-energydensity batteries. Physical safety designs such as employing circuit-breakers and fuses to batteries are limited by small operating voltage windows and no resumption of original working condition when it is cooled down. Here we report a smart thermoresponsive polymer electrolyte that can be incorporated inside batteries to prevent thermal runaway via a fast and reversible sol-gel transition, and successfully combine this smart electrolyte with a rechargeable Zn/a-MnO_2 battery system. At high temperature, battery operation is inhibited as a result of the increased internal resistance caused by the gelation of liquid electrolyte. After cooling down, the electrolyte is spontaneously reversed to sol state and the electrochemical performance of the battery is restored. More importantly, sol-gel transition enables the smart battery to experience different charge-discharge rates under various temperature levels, providing a smart and active strategy to achieve dynamic and reversible self-protection. | Funian Mo Hongfei Li Zengxia Pei Guojin Liang Longtao Ma Qi Yang Donghong Wang Yan Huang Chunyi Zhi | 2018 | Science Bulletin2018，63，16： | 13 |
| 6 | Mineral Chemistry and Crystallization Conditions of the Late Cretaceous Mamba Pluton from the Eastern Gangdese, Southern Tibetan Plateau显示文摘The Late Cretaceous Mamba granodiorite belongs to a part of the Mesozoic Gangdese continental magmatic belt. No quantitative mineralogical study has been made hitherto, and hence the depth at which it formed is poorly constrained. Here we present mineralogical data for the Mamba pluton, including host rocks and their mafic microgranular enclaves(MMEs), to provide insights into their overall crystallization conditions and information about magma mixing. All amphiboles in the Mamba pluton are calcic, with ~B(Ca+Na)>1.5, and Si=6.81–7.42 apfu for the host rocks and Si=6.77–7.35 apfu for the MMEs. The paramount cation substitutions in amphibole include edenite type and tschermakite type. Biotites both in the host rocks and the MMEs collectively have high Mg O(13.19 wt.%–13.03 wt.%) contents, but define a narrow range of Al apfu(atoms per formula unit) variations(2.44–2.57). The oxygen fugacity estimates are based on the biotite compositions cluster around the NNO buffer. The calculated pressure ranges from 1.2 to 2.1 kbar according to the aluminum-in-hornblende barometer. The computed pressure varies from 0.9 to 1.3 kbar based on the aluminum-in-biotite barometer which corresponds to an average depth of ca. 3.9 km. Besides, the estimates of crystallization pressures vary from 0.8 to 1.4 kbar based on the amphibole barometer proposed by Ridolfi et al.(2010), which can be equivalent to the depths ranging from 3.1 to 5.2 km. The MMEs have plagioclase oscillatory zonings and quartz aggregates, probably indicating the presence of magma mixing. Besides, core-to-rim element variations(Rb, Sr, Ba, and P) for the K-feldspar megacrysts serve as robust evidence to support magma mixing and crystal fractionation. This indicates the significance of the magma mixing that contributes to the formation of K-feldspar megacryst zonings in the Mamba pluton. | Xiaowei Li Xuanxue Mo Mark Scheltens Qi Guan | 2016 | Journal of Earth Science2016，27，4： | 11 |
| 7 | Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii显示文摘Mogrosides and steroid saponins are tetracyclic triterpenoids found in Siraitia grosvenorii.Squalene synthase(SQS) and cycloartenol synthase(CAS) are key enzymes in triterpenoid and steroid biosynthesis.In this study,full-length cDNAs of SgSQS and SgCAS were cloned by a rapid amplification of cDNA-ends with polymerase chain reaction(RACE-PCR) approach.The SgSQS cDNA has a 1254 bp open reading frame(ORF) encoding 417 amino acids,and the SgCAS cDNA contains a 2298 bp ORF encoding 765 amino acids.Bioinformatic analysis showed that the deduced SgSQS protein has two transmembrane regions in the C-terminal.Both SgSQS and SgCAS have significantly higher levels in fruits than in other tissues,suggesting that steroids and mogrosides are competitors for the same precursors in fruits.Combined in silico prediction and subcellular localization,experiments in tobacco indicated that SgSQS was probably in the cytoplasm or on the cytoskeleton,and SgCAS was likely located in the nucleus or cytosol.These results will provide a foundation for further study of SgSQS and SgCAS gene functions in S.grosvenorii,and may facilitate improvements in mogroside content in fruit by regulating gene expression. | Huan Zhao Qi Tang Changming Mo Longhua Bai Dongping Tu Xiaojun Ma | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 10 |
| 8 | Clinicopathological and molecular genetic analysis of 4 typical Chinese HNPCC families显示文摘AIM: To study the clinicopathological and molecular genetic characteristics of typical Chinese hereditary nonpolyposis cotorectal cancer (HNPCC) families.METHODS: Four typical Chinese HNPCC families were analyzed using microdissection, microsatellite instability analysis, immunostaining of hMSH2 and hMLH1 proteins and direct DNA sequencing of hMSH2 and hMLH1 genes.RESULTS: All five tumor tissues of 4 probands from the 4typical Chinese HNPCC families showed microsatellite instability at more than two loci (MSI-H or RER +phenotype). Three out of the 4 cases lost hMSH2 protein expression and the other case showed no hMLH1 protein expression. Three pathological germline mutations (2 in hMSH2 and 1 in hMLH1 ), which had not been reported previously, were identified. The same mutations were also found in otler affected members of two HNPCC families,respectively.CONCLUSION: Typical Chinese HNPCC families showed relatively frequent germline mutation of mismstch repair genes. High-level microsateliita instability and loss of expression of mismatch repair genes correlated closely with germline mutation of mismatch repair genes. Microsatellite instability analysis and immunostaining of miamstch repair gens might serve as effective screening methods before direct DNA sequencing. It is necessary to establish clinical criteria and molecular diagnostic strategies more suitable for Chinese HNPCC families. | Qi Cai~1 Meng-Hong Sun~1 Hong-Fen Lu~1 Tai-Ming Zhang~1 Shan-Jing Mo~2 Ye Xu~2 San-Jun Cai~2 Xiong-Zeng Zhu~1 Da-Ren Shi~1 1 Department of Pathology2 Department of Abdominal Surgery,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，6： | 10 |
| 9 | Bifurcation analyses and hardware experiments for bursting dynamics in non-autonomous memristive FitzHugh-Nagumo circuit显示文摘In this paper,a non-autonomous memristive Fitz Hugh-Nagumo(FHN)circuit is constructed using a second-order memristive diode bridge with LC network.For convenience of circuit implementation,an AC voltage source is adopted to substitute the original AC current stimulus.Stimulated by the slowly varying AC voltage source,the number,locations and stabilities of the equilibrium points slowly evolve with the time,which are thus indicated as the AC equilibrium points.Different sequences of fold and/or Hopf bifurcations are encountered in a full period of time series evolutions,leading to various kinds of chaotic or periodic bursting activities.To figure out the related bifurcation mechanisms,the fold and Hopf bifurcation sets are mathematically formulated to locate the critical bifurcation points.On this basis,the transitions between the resting and repetitive spiking states are clearly illustrated by the time series of the AC equilibrium points and state variables,from which Hopf/sub Hopf,Hopf/Hopf,and Hopf/fold bursting oscillations are identified in the specified parameter regions.Finally,based on a fabricated hardware circuit,the experimental measurements are executed.The results verify that the presented memristive FHN circuit indeed exhibits complex bursting activities,which enriches the family of memristor-based FHN circuits with bursting dynamics. | CHEN Mo QI JianWei WU HuaGan XU Quan BAO BoCheng | 2020 | Science China(Technological Sciences)2020，63，6： | 9 |
| 10 | Recent Progress of MXene-Based Nanomaterials in Flexible Energy Storage and Electronic Devices显示文摘The increasing demands for wearable electronics have stimulated the rapid development of flexible energy storage devices.MXenes are considered as promising flexible electrodes due to the ultrahigh volumetric specific capacitance,metallic conductivity,superior hydrophily,and rich surface chemistry. | Qi Yang Yukun Wang Xinliang Li Hongfei Li Zifeng Wang Zijie Tang Longtao Ma Funian Mo Chunyi Zhi | 2018 | Energy & Environmental Materials2018，1，4： | 8 |
| 11 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 12 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 13 | PPAR-y2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China显示文摘 | Qi PEI Qiong HUANG Guo-ping YANGI Ying-chun ZHAO Ji-ye YIN Min SONG Yi ZHENG Zhao-hui MO Hong-hao ZHOU Zhao-qian LIU | 2013 | Acta Pharmacologica Sinica2013，34，2： | 7 |
| 14 | Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization显示文摘This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide(ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells as well as the expression intensity of TNF-α and IL-1β was greater in the GVHD group than in the BM group, whereas the number of F4/80+CD206+ cells and the expression intensity of IL-10 and TGF-β was greater in the BM group than in the GVHD group. We investigated the effect of ATO on GVHD mice, and found that ATO treatment clearly improved the survival of the mice and reduced the severity of GVHD. In addition, ATO reduced the number of F4/80+iNOS+ cells, and increased the number of F4/80+CD206+ cells in the colon of GVHD mice. Furthermore, ATO sharply decreased CD86 and CD80 expression, and increased CD163 and CD206 expression in macrophages induced from aGVHD patients. Therefore,ATO can modulate the M1 and M2 phenotype in GVHD mice or in macrophages from aGVHD patients. Our data suggest that macrophage polarization is involved in the pathogenesis of aGVHD, and ATO treatment modulates macrophage polarization toward an M2 phenotype. | Xiao Liu Yan Su Xueyan Sun Haixia Fu Qiusha Huang Qi Chen Xiaodong Mo Meng Lv Yuan Kong Lanping Xu Xiaojun Huang Xiaohui Zhang | 2020 | Science China(Life Sciences)2020，63，11： | 6 |
| 15 | Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation. | Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi | 2019 | Green Energy & Environment2019，4，2： | 6 |
| 16 | Overexpression of GmBIN2,a soybean glycogen synthase kinase 3 gene,enhances tolerance to salt and drought in transgenic Arabidopsis and soybean hairy roots显示文摘Glycogen synthase kinase 3(GSK3)is a kind of serine/threonine kinase widely found in eukaryotes.Many plant GSK3 kinases play important roles in regulating stress responses.This study investigated BRASSINOSTEROID-INSENSITIVE 2(GmBIN2)gene,a member of the GSK3 protein kinase family in soybean and an orthologue of Arabidopsis BIN2/At SK21.GmBIN2 expression was increased by salt and drought stresses,but was not significantly affected by the ABA treatment.To examine the function of GmB IN2,transgenic Arabidopsis and transgenic soybean hairy roots were generated.Overexpression of GmBIN2 in Arabidopsis resulted in increased germination rate and root length compared with wild-type plants under salt and mannitol treatments.Overexpression of GmBIN2 increased cellular Ca^(2+) content and reduced Na+content,enhancing salt tolerance in transgenic Arabidopsis plants.In the soybean hairy root assay,overexpression of GmBIN2 in transgenic roots also showed significantly higher relative root growth rate than the control when subjected to salt and mannitol treatments.Measurement of physiological indicators,including proline content,superoxide dismutase(SOD)activity,and relative electrical conductivity,supported this conclusion.Furthermore,we also found that GmBIN2 could up-regulate the expression of some stress-related genes in transgenic Arabidopsis and soybean hairy roots.Overall,these results indicated that GmBIN2 improved tolerance to salt and drought in transgenic Arabidopsis and soybean hairy roots. | WANG Ling-shuang CHEN Qing-shan XIN Da-wei QI Zhao-ming ZHANG Chao LI Si-nan JIN Yang-mei LI Mo MEI Hong-yao SU Anoyu WU Xiao-xia | 2018 | Journal of Integrative Agriculture2018，17，9： | 4 |
| 17 | The Effect of Body Pitching on Leg-Spring Behavior in Quadruped Running显示文摘In this paper we investigated how the running speed would affect the dynamics of body pitching, and whether body inertiais important for animals. Passive trotting of spring-mass model and passive bounding of spring-beam model were studied atdifferent speeds for different sets of body parameters respectively. Furthermore, different body inertias were used in bounding.We found that running speed exerts effect on leg performance by means of centrifugal force. The centrifugal force can be understoodas an enhancement to the natural frequency of the spring-mass system. The disadvantage of body pitching may beoffset by the great increase in centrifugal force at high speed. The results also reveal that body mass distribution might not be themain reason for the difference in maximal running speeds of different animals. | Qi Deng, Shigang Wang, Qinghua Liang, Jinqiu Mo School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240 P. R. China | 2010 | Journal of Bionic Engineering2010，7，3： | 4 |
| 18 | Efficient oxygen reduction reaction by a highly porous,nitrogen-doped carbon sphere electrocatalyst through space confinement effect in nanopores显示文摘A highly porous nitrogen-doped carbon sphere(NPC)electrocatalyst was prepared through the carbonization of biomass carbon spheres mixed with urea and zinc chloride in N_(2) atmosphere.The sample carbonized at.1000℃ demonstrates a superior oxygen reduction reaction(ORR)performance over the Pt/C electrocatalyst,while its contents of pyridinic nitrogen and graphitic nitrogen are the lowest among samples synthesized at the same or lower carbonization temperatures.This unusual result is explained by a space confinement effect from the microporous and mesoporous structures in the microflakes,which induces the further reduction of peroxide ions or other oxygen species produced in the first step reduction to water to have the preferred overall four electron reduction ORR process.This work demonstrates that in addition to the amount or species of its aptive sites,the space confinement can be a new approach to enhance the ORR performance of precious-metal-free,nitrogen-doped carbon electrocatalysts. | Zheyang MO Weiyi YANG Shuang GAO Jian Ku SHANG Yajun DING Wuzhu SUN Qi LI | 2021 | Journal of Advanced Ceramics2021，10，4： | 3 |
| 19 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 20 | Cloning and expression of SgCYP450-4from Siraitia grosvenorii显示文摘CYP450 plays an essential role in the development and growth of the fruits of Siraitia grosvenorii. However, little is known about the SgCYP450-4 gene in S. grosvenorii. Here, based on transcriptome data, a full-length c DNA sequence of SgCYP450-4 was cloned by reverse transcriptasepolymerase chain reaction(RT-PCR) and rapid-amplification of c DNA ends(RACE) strategies. SgCYP450-4 is 1677 bp in length(Gen Bank accession No. AEM42985.1) and contains a complete open reading frame(ORF) of 1422 bp. The deduced protein was composed of 473 amino acids, the molecular weight is 54.01 kDa, the theoretical isoelectric point(PI) is 8.8, and the protein was predicted to possess cytochrome P450 domains. SgCYP450-4 gene was highly expressed in root, diploid fruit and fruit treated with hormone and pollination. At 10 days after treatment with pollination and hormones, the expression of SgCYP450-4had the highest level and then decreased over time, which was consistent with the development of fruits of S.Grosvenorii. Hormonal treatment could significantly induce the expression of SgCYP450-4. These results provide a reference for regulation of fruit development and the use of parthenocarpy to generate seedless fruit, and provide a scientific basis for the production of growth regulator application agents. | Dongping Tu Xiaojun Ma Huan Zhao Changming Mo Qi Tang Liuping Wang Jie Huang Limei Pan | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 3 |
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