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| 1 | Inflammation and immunosuppression in severe acute pancreatitis显示文摘Acute pancreatitis(AP) is a common disease,which usually exists in its mild form.However,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or both.Because the development of organ failure is the major cause of death in AP,early identification of patients likely to develop organ failure is important.AP is initiated by intracellular activation of pancreatic proenzymes and autodigestion of the pancreas.Destruction of the pancreatic parenchyma first induces an inflammatory reaction locally,but may lead to overwhelming systemic production of inflammatory mediators and early organ failure.Concomitantly,anti-inflammatory cytokines and specific cytokine inhibitors are produced.This anti-inflammatory reaction may overcompensate and inhibit the immune response,rendering the host at risk of systemic infection.At present,there is no specific treatment for AP.Increased understanding of the pathogenesis of systemic inflammation and development of organ dysfunction may provide us with drugs to ameliorate physiological disturbances. | Marja-Leena Kylnp Heikki Repo Pauli Antero Puolakkainen | 2010 | World Journal of Gastroenterology2010，16，23： | 97 |
| 2 | 北京地区儿童急性下呼吸道感染的病原学研究显示文摘目的 探讨儿童急性下呼吸道感染 (ALRI)的病原学。方法 采用血培养及常用的抗原、抗体检测方法检测 10 2例ALRI患儿常见的致病原。结果 (1) 10 2例儿童ALRI中 ,明确病原诊断的有 6 0例 (5 8.8% )。 (2 )在检出病原的 6 0例中 ,单纯细菌感染 15例 (2 5 % ) ,单纯病毒感染 19例(32 % ) ,单纯支原体感染 8例 (13% ) ,单纯衣原体感染 1例 (2 % ) ,混合感染 17例 (2 8% )。 (3)检出的主要病原 :10 2例ALRI,患儿中 ,呼吸道合胞病毒 (RSV) 2 9例 (2 8.4% ) ,其后依次是肺炎链球菌 17例(16 .7.% ) ,b型流感嗜血杆菌 (Hib) 14例 (13.7% ) ,支原体 11例 (10 .8% ) ,卡他摩拉菌及衣原体急性感染各 2例 (2 .0 % )。结论 RSV是儿童ALRI最常见的病原 ,其次是肺炎链球菌、b型流感嗜血杆菌。 | 王亚娟 姚德秀 燕润菊 王春莲 幺远 Anne Jaakkola Maija Leinonen Didier Leboulleux Heikki Peltola 杨永弘 | 2000 | 中华儿科杂志2000，38，3： | 133 |
| 3 | Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease显示文摘AIM: To characterize the bifidobacterial microbiota of the colonic mucosa in patients with colon cancer, inflammatory bowel disease or diverticulitis. METHODS: A sample of the distal colonic mucosa was taken during surgery from a total of 34 patients, twenty-one with diagnosed colorectal cancer, nine with diverticulitis and four with inflammatory bowel disease, requiring surgery for their condition. Bacterial DNA was extracted from the resected mucosal samples and bifidobacterial mucosa-associated microbiota was qualitatively and quantitatively determined by means of qualitative and quantitative PCR. RESULTS: Bifidobacteria were found in 100% of the samples from patients with diverticulitis or IBD and a 76% of those suffering colon cancer. The species B. longum and B. bifidum were the most widely found, followed by B. animalis, B. catenulatum and B. adolescentis. B. breve, B. dentium and B. angulatum were not detected in any sample. A significantly higher occurrence of B. longum was observed in patients with diverticulitis than in those with colon cancer or IBD (100%, 62% and 75%, respectively, P < 0.05). Similar results were obtained for B. animalis (56%, 0% and 25%, P < 0.05), while B. adolescentis was only found in the mucosa from patients with colon cancer (5 out of 21, 24%). At the quantitative level, patients with colon cancer or IBD showed lower counts of total Bifidobacterium (4.94 and 5.91 vs 6.96 log Cells/sample, respectively, P < 0.05) and of the species B. longum (4.05 and 4.79 vs 6.76, P < 0.05) than those with diverticulitis. CONCLUSION: Aberrancies in mucosa associated microbiota are present in different intestinal diseases. This may indicate a role of the microbiota in the pathogenesis of these diseases. | Miguel Gueimonde Arthur Ouwehand Heikki Huhtinen Eeva Salminen Seppo Salminen | 2007 | World Journal of Gastroenterology2007，13，29： | 25 |
| 4 | 肺炎衣原体在儿童急性下呼吸道感染中的情况显示文摘目的 探讨肺炎衣原体在急性下呼吸道感染 (ALRI)中的感染情况。方法 收集 1997年和 1998年两年冬、春季节、年龄在 3个月~ 14岁、起病在 1周以内、诊断为ALRI的 2 0 1例患儿的配对血清标本 ,其中 1997年 10 0例 ,1998年 10 1例 ,通过使用荧光免疫 (MIF)方法检测其肺炎衣原体抗体。结果 2 0 1例ALRI儿童中 ,急性肺炎衣原体感染 2 3例 ( 11 4%) ,既往感染 63例 ( 3 1 3 %)。在1997年检测的 10 0例中 ,急性感染 2 1例 ( 2 1 0 %) ,既往感染 3 3例 ( 3 3 0 %) ;1998年检测的 10 1例中 ,急性感染仅 2例 ( 2 0 %) ,既往感染 3 0例 ( 2 9 7%)。两年度比较 ,既往感染率接近 (P >0 0 5 ) ,而急性感染率差异有非常显著意义 ,1997年急性感染率随年龄的增长而上升 ,1998年未显示年龄间差异。结论 在ALRI患儿中 ,存在肺炎衣原体感染 ,1997年的感染率高于 1998年。 | 王亚娟 沈叙庄 佟月娟 姚德秀 燕润菊 王春莲 幺远 刘钢 Mikka Paldanius Maija Leinonen Heikki Peltola 杨永弘 | 2001 | 中华儿科杂志2001，39，9： | 22 |
| 5 | J波综合征专家上海共识:概念与认知的更新显示文摘序言
J波综合征(J wave syndromes,JW Ss),包括Brugada综合征(BrS)和早复极综合征(ERS)。有关Br S,在2000年和2004年分别举行了BrS的国际专家共识会议;有关ERS,直到2013年才在原发性遗传性心律失常专家共识里做出了针对ERS的指导意见。在2015年4月,心脏节律协会(HRS)、欧洲心脏节律协会(EHRA)和亚洲太平洋心脏节律协会(APHRS)的主要专家成员组成的工作组聚集在中国上海,审查了有关JWSs的新证据, | Charles Antzelevitch 严干新 Michael J.Ackerman Martin Borggrefe Domenico Corrado 郭继鸿(审核) Ihor Gussak Can Hasdemir Minoru Horie Heikki Huikuri 马长生 Hiroshi Morita Gi-Byoung Nam Frederic Sacher Wataru Shimizu Sami Viskin Arthur A.M.Wilde 刘霄燕(译) 揭起强(译) 吴林(审核) | 2016 | 临床心电学杂志2016，25，3： | 21 |
| 6 | 急性肺炎多病原混合感染的检测及分析显示文摘目的 了解急性肺炎时肺炎链球菌 (SP)、流感嗜血杆菌 (Hi)、卡他布兰汉菌 (BC)、肺炎支原体 (MP)及肺炎衣原体 (CP)等多病原混合感染的发病情况。方法 采用酶免疫分析法 ,对 5 3例住院急性肺炎患儿的双份血清进行不定型Hi抗体、B型Hi荚膜多糖抗体和全菌抗体进行检测 ,SP溶血素抗体和C 多糖抗体 ,循环免疫复合物中SP溶血素抗体、表面蛋白A抗体和C 多糖抗体 ,CB全菌抗体及MP抗体的检测 ;采用免疫荧光法检测患儿双份血清中CP抗体 ;并同时进行血液普通细菌培养。结果 5 3例肺炎患儿中 32例 (占 6 0 .4 % )病原学检测阳性。其中单一病原体感染 2 1例 ,2种和 3种病原体混合感染分别为 8例和 3例。在各种病原体中 ,SP和CP感染最常见 (各占 2 0 .8% ,11/ 5 3) ,其次为MP感染 (占 16 .7% ,7/ 4 2 )和Hi感染 (占 13.2 % ,7/ 5 3)。结论 急性肺炎时SP、CP、MP和Hi等是常见的病原 ,在小儿肺炎经验治疗时 ,多病原体混合感染情况应予以重视。 | 王亚亭 杨永弘 胡允文 王亚娟 Didier Leboulleux Maija Leinonen Heikki Peltola | 2004 | 实用儿科临床杂志2004，19，6： | 15 |
| 7 | b型流感嗜血杆菌在儿童急性下呼吸道感染中的地位显示文摘 | 杨永弘 王亚娟 姚德秀 燕润菊 王春连 幺远 Anne Jaakkola Maija Leinonen Didier Leboulleux Heikki Peltola | 2000 | 中华医学杂志2000，80，5： | 13 |
| 8 | 气团来源对瓦里关地区颗粒物数谱分布的影响显示文摘通过对2005年8月到2007年5月在瓦里关全球本底站观测的气溶胶数谱分布资料和同期后向轨迹资料分析,发现气团来源对瓦里关地区颗粒物的数浓度及其谱分布有显著影响.气团起源于瓦里关东北部地区或者途径东北部地区,传输路径较短,传输速度相对较慢,大气中出现较高数浓度的爱根核模态颗粒物;气团来源于瓦里关西部或者西北地区时,传输路径较长,传输速度较快,大气中一般出现较高浓度的核模态颗粒物. | 占明锦 孙俊英 张养梅 张晓春 乜虹 德力格尔 Niku Kivekas Heikki Lihavainen | 2009 | 冰川冻土2009，31，4： | 12 |
| 9 | Even low-grade inflammation impacts on small intestinal function显示文摘Independent of the cause and location,inflammation-even when minimal-has clear effects on gastrointestinal morphology and function.These result in altered digestion,absorption and barrier function.There is evidence of reduced villus height and crypt depth,increased permeability,as well as altered sugar and peptide absorption in the small intestine after induction of inflammation in experimental models,which is supported by some clinical data.Identification of inflammatory factors which may promote the process of gastrointestinal dysfunction as well as clinical research to verify experimental observations of inflammatory modulation of gastrointestinal function are required.Moreover,nutritional strategies to support functional restitution are needed. | Katri Peuhkuri Heikki Vapaatalo Riitta Korpela | 2010 | World Journal of Gastroenterology2010，16，9： | 9 |
| 10 | Risk stratification of patients diagnosed with gastrointestinal stromal tumor显示文摘 | Heikki Joensuu | 2008 | Human Pathology2008，，10： | 8 |
| 11 | 沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响显示文摘目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。 | 王养正 吴英 Heikki Kallio Yang Baoru 王军宪 王秉文 崔刚 | 2008 | 西安交通大学学报(医学版)2008，29，6： | 8 |
| 12 | 不同产地沙棘果的成分分析显示文摘通过沙棘甘油三酯和甘油磷脂中的糖、果酸(气相色谱-质谱法,TMS衍生物)、矿物质(FAAS,ETAAS)、挥发性物质(顶部空间气相色谱-质谱法)、Vc(高压液相色谱)和脂肪酸(气相色谱-质谱法,甲基酯)的分析方法,优化不同产地的沙棘果。对1997年10-11月采集的中国沙棘果(CH)和8月底采集的芬兰沙棘果(FI)和俄罗斯沙棘果(RU)的成分进行比较,得到了为今后开展更广泛的沙棘项目所需要的足够的资料。中国沙棘果汁中的Vc含量极高,平均8g/l(4.2-13.2g/l),是芬兰沙棘果汁中含量的5倍。主要矿物元素的含量比其它可食用的浆果中丰富得多,钾是沙棘果(6-14g/kg,干重)和沙棘籽(5-9g/kg,干重)中的主要矿物质之一,在一些样品中铅和镉含量的增加表明存在轻微的污染。压榨的沙棘果汁中糖的含量从1-20g/100ml有很大的变化,含量最高的是晚秋收获的中国沙棘果,最低的是8月收获的芬兰沙棘果。糖主要是葡萄糖(占总糖分的50%以上)、果糖及葡萄糖衍生物。苹果酸和奎宁酸是主要的果酸(77%-97%),含量为每100ml果汁中4.2-9.1g。果汁上部油脂的特点是形成了C2-C5n-、iso-、和ante-iso乙醇,C4-C5n-,iso,及ante-ISO酸,也呈现出挥发性油脂的籽油乙醇前体。不同的产地和采收时间对挥发物有着明显的影响,整个果中的含油量为2%-11%(鲜重)。 | Heikki Kallio Yang Baoru Raija Tahvonen Mari Hakala 许涛 卢顺光 | 2003 | 国际沙棘研究与开发2003，，1： | 7 |
| 13 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 14 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 15 | Diabetes:特殊免疫细胞亚群或促进1型糖尿病发展显示文摘发表在国际杂志Diabetes上的一项最新研究中,来自东芬兰大学的研究人员通过研究发现,最近描述的一种T细胞亚群或许在1型糖尿病的发生上扮演着关键性的中枢角色;这种名为滤泡T辅助细胞的T细胞亚群在1型糖尿病开始阶段时水平处于增加之中,而且这种现象和疾病相关的常见自身抗体的存在直接相关。 | Tyyne Viisanen Emmi-Leena Ihantola Kirsti Näntö-Salonen Heikki Hyöty Noora Nurminen Jenni Selvenius Auni Juutilainen Leena Moilanen Jussi Pihlajamäki Riitta Veijola Jorma Toppari Mikael Knip Jorma Ilonen Tuure Kinnunen | 2017 | 现代生物医学进展2017，17，4： | 5 |
| 16 | Digitalization of mine operations:Scenarios to benefit in real-time truck dispatching显示文摘One of the key factors in a profitable open-pit mine is the efficiency of the waste disposal system. Using GPS-technology, the truck-dispatching decisions can be made in real-time but the chosen strategy has a crucial role. Therefore, finding the optimal dispatching strategy for truck-shovel operations is extremely important. Dispatching strategies have been reported in the literature, but the comparison of these strategies is still missing. This paper illustrates the differences between the strategies by conducting a stochastic simulation study based on the data gathered from an actual mine. The findings underline the importance of the global vision in dispatching decisions. | Patarawan Chaowasakoo Heikki Seppala Heikki Koivo Quan Zhou | 2017 | International Journal of Mining Science and Technology2017，27，2： | 4 |
| 17 | 沙棘果油和籽油抗炎作用的实验研究显示文摘为了解研究沙棘果油及沙棘籽油的抗炎作用。用小白鼠耳二甲苯致炎法进行实验,结果表明,与阴性对照组比较,沙棘果油及沙棘籽油高、低剂量组小白鼠耳廓肿胀度明显的减小(P<0.01或P<0.05);沙棘果油及沙棘籽油高、低剂量组间比较,其耳廓肿胀度无明显差异(P>0.05)。结果提示,沙棘果油及沙棘籽油有明显的抗炎作用,并且沙棘果油及沙棘籽油的抗炎作用没有明显差异。用大鼠足跖蛋清致肿法进行实验,结果表明:与阴性对照组比较,沙棘果油及沙棘籽油高、低剂量组大鼠致炎后右后足跖肿胀率无明显变化(均为P>0.05)。鸡蛋清所致大鼠足跖水肿主要以组织胺,5-HT为介质,可能沙棘果油及沙棘籽油对这种炎症模型无明显影响。 | 王秉文 林晓茵 王红英 宋杰 王放 王军宪 Heikki kallio Yang Baoru | 2007 | 沙棘2007，，3： | 4 |
| 18 | Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans显示文摘The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans(CSPGs) inhibit plasticity and regeneration in the adult central nervous system(CNS). We argue that the role of the CSPGs can be reversed from inhibition to activation by developmentally expressed CSPG-binding factors. Heparin-binding growth-associated molecule(HB-GAM; also designated as pleiotrophin) has been studied as a candidate molecule that might modulate the role of CSPG matrices in plasticity and regeneration. Studies in vitro show that in the presence of soluble HB-GAM chondroitin sulfate(CS) chains of CSPGs display an enhancing effect on neurite outgrowth. Based on the in vitro studies, we suggest a model according to which the HB-GAM/CS complex binds to the neuron surface receptor glypican-2, which induces neurite growth. Furthermore, HB-GAM masks the CS binding sites of the neurite outgrowth inhibiting receptor protein tyrosine phosphatase sigma(PTPσ), which may contribute to the HB-GAM-induced regenerative effect. In vivo studies using two-photon imaging after local HB-GAM injection into prick-injury of the cerebral cortex reveal regeneration of dendrites that has not been previously demonstrated after injuries of the mammalian nervous system. In the spinal cord, two-photon imaging displays HB-GAM-induced axonal regeneration. Studies on the HB-GAM/CS mechanism in vitro and in vivo are expected to pave the way for drug development for injuries of brain and spinal cord. | Heikki Rauvala Mikhail Paveliev Juha Kuja-Panula Natalia Kulesskaya | 2017 | Neural Regeneration Research2017，12，5： | 4 |
| 19 | b型嗜血流行性感冒杆菌在急性下呼吸道感染病原学中的地位显示文摘 | 王亚娟 杨永弘 沈叙庄 王亚亭 胡允文 姚德秀 佟月娟 Heikki Peltola Didier Leboulleux | 2004 | 中国计划免疫2004，10，3： | 3 |
| 20 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
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