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| 1 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 2 | A murine model of experimental metastasis to bone and bone marrow显示文摘 | Arguello F Baggs RB Frantz CN | 1988 | Cancer Res1988，48，23： | 1 |
| 3 | Incidence and distribution of experimental me-tastases in mutant mice with defective organ microenvironments (genotypes SI/Sld and W/Wv)显示文摘 | Arguello F | 1992 | Cancer Res1992，52，8： | 1 |
| 4 | A GRASP for aircraft routing in response to groundings and delays显示文摘 | Arguello M F Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，5，： | 1 |
| 5 | A grasp for aircraft routing in response to groundings and delay显示文摘 | Arguello M Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，1，3： | 1 |
| 6 | Optimizing aircraft routing in response to groundings and delays显示文摘 | Bard J F Yu G Arguello M F | 2001 | IIE Transaction2001，33，： | 1 |
| 7 | High-performance VLSI architecture for the Viterbi algorithm显示文摘 | Boo M Arguello F Bruguera J D | 1997 | IEEE Trans Communications1997，45，2： | 1 |
| 8 | Optimizing aircraft routings in response to groundings and delays 显示文摘 | Bard J F Yu G Arguello M F | 2001 | IIE Transactions2001，33，： | 1 |
| 9 | Parallel architecture for fast transforms with trigonometric kernel显示文摘 | Arguello F Bruguera J D Doallo R | 1994 | IEEE Trans Parallel and Distributed Systems1994，5，10： | 1 |
| 10 | Pathogenesis of Vertebral Metastasis and Epidural Spinal Cord Compression 显示文摘 | Arguello F Baggs RB Duerst RE | 1990 | Cancer1990，65，1： | 1 |
| 11 | A GRASP for air- craft routing in response to groundings and delays 显示文摘 | Arguello M F Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，1997，5： | 1 |
| 12 | Vascular anatomy and organ-specific tumor growth as critical factors in the develop-ment of metastasis and their distribution among organs显示文摘 | Arguello F Baggs RB Eskenazi AE | | 0，，04： | 1 |
| 13 | Pathogenesis of vertebral metastasis and epidural spinal cord compression显示文摘 | Arguello F Baggs RB Duerst RE | 1990 | Cancer1990，65，： | 1 |
| 14 | A GRASP for aircraft routing in response to groundings and delays 显示文摘 | Arguello M F Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，5，： | 1 |
| 15 | A murine model of experimental metastasis to bone and bone marrow显示文摘 | Arguello F Baggs RB Frantz CN | 1988 | Cancer Res1988，48，： | 1 |
| 16 | Flavopiridol induces ap- optosis of normal lymphoid ceils, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lympho- ma xenografts 显示文摘 | Arguello F Alexander M Sterry JA et at | 1998 | Blood1998，91，7： | 1 |
| 17 | A GRASP for aircraft routing in response to groundings and delays 显示文摘 | Arguello M F Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，5，： | 1 |
| 18 | A murine model of experimental metastasis to bone and bone marrow 显示文摘 | Baqqs RB Frantz CN | 1988 | Cancer Res1988，48，23： | 1 |
| 19 | Incidence and distribution of experimental metastasis in mutant mice with defective organ microenvironments 显示文摘 | Furlanetto RW Baggs RB | 1992 | Cancer Res1992，52，8： | 1 |
| 20 | Vascular anatomy and organ-specific tumor growth as critical factors in the development of metastasis and their distribution among organs 显示文摘 | Baggs RB Eskenazi AE | 1991 | Int J Cancer1991，48，4： | 1 |
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