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您的检索式：作者名="Arne Klungland"
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| 1 | Endogenous DNA Damage and Repair Enzymes—A short summary of the scientific achievements of Tomas Lindahl,Nobel Laureate in Chemistry 2015显示文摘Tomas Lindahl completed his medical studies at Karolinska Institute in 1970.Yet,his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair.His research is characterized with groundbreaking discoveries on the instability of our genome,the identification of novel DNA repair activities,the characterization of DNA repair pathways,and the association to diseases,throughout his 40 years of scientific career. | Arne Klungland Yun-Gui Yang | 2016 | Genomics, Proteomics & Bioinformatics2016，14，3： | 2 |
| 2 | Base-excision repair and beyond—A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015显示文摘Tomas Lindahl contributed his scientific career to unveiling fundamental mechanisms of DNA decay and repair.He made several ground-breaking discoveries on genome instability,novel DNA repair activities and pathways,and disease association.The 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl,Paul Modrich and Aziz Sancar for their mechanistic studies of DNA repair.Their findings | Shuangli Mi Arne Klungland Yun-Gui Yang | 2016 | Science China(Life Sciences)2016，59，1： | 0 |
| 3 | Non-homologous functions of the AlkB homologs显示文摘TheDNArepair enzyme AlkB was identified in E.coli more than three decades ago.Since then,nine mammalian homologs,all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases,have been identified(designated ALKBH1–8 and FTO).While E.coli AlkB serves as a DNA repair enzyme,only two mammalian homologs have been confirmed to repair DNA in vivo.The other mammalian homologs have remarkably diverse substrate specificities and biological functions.Substrates recognized by the different AlkB homologs comprise erroneous methyl-and etheno adducts in DNA,unique wobble uridine modifications in certain tRNAs,methylated adenines in mRNA,and methylated lysines on proteins.The phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity,severe sensitivity to inflammation,infertility,growth retardation,and multiple malformations.Here we review the present knowledge of the mammalian AlkB homologs and their implications for human disease and development. | Rune Ougland Torbjørn Rognes Arne Klungland Elisabeth Larsen | 2015 | Journal of Molecular Cell Biology2015，7，6： | 0 |
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