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| 1 | Endoscopic mucosal resection and endoscopic submucosal dissection in the treatment of sporadic nonampullary duodenal adenomatous polyps显示文摘Although uncommon, sporadic nonampullary duodenal adenomas have a growing detection due to the widespread of endoscopy. Endoscopic therapy is being increasingly used for these lesions, since surgery, considered the standard treatment, carries significant morbidity and mortality. However, the knowledge about its risks and benefits is limited, which contributes to the current absence of standardized recommendations. This review aims to discuss the efficacy and safety of endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) in the treatment of these lesions. A literature review was performed, using the Pubmed database with the query: '(duodenum or duodenal)(endoscopy or endoscopic) adenoma resection', in the human species and in English. Of the 189 retrieved articles, and after reading their abstracts, 19 were selected due to their scientific interest. The analysis of their references, led to the inclusion of 23 more articles for their relevance in this subject. The increased use of EMR in the duodenum has shown good results with complete resection rates exceeding 80% and low complication risk(delayed bleeding in less than 12% of the procedures). Although rarely used in the duodenum, ESD achieves close to 100% complete resection rates, but is associated with perforation and bleeding risk in up to one third of the cases. Even though literature is insufficient to draw definitive conclusions, studies suggest that EMR and ESD are valid options for the treatment of nonampullary adenomas. Thus, strategies to improve these techniques, and consequently increase the effectiveness and safety of the resection of these lesions, should be developed. | Joana Marques Francisco Baldaque-Silva Pedro Pereira Urban Arnelo Naohisa Yahagi Guilherme Macedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 13 |
| 2 | Methods and outcomes of screening for pancreatic adenocarcinoma in high-risk individuals显示文摘Pancreatic ductal adenocarcinoma(PDAC) is a lethal neoplasia, for which secondary prevention(i.e., screening) is advisable for high-risk individuals with 'familiar pancreatic cancer' and with other specific genetic syndromes(Peutz-Jeghers, p16, BRCA2, PALB and mismatch repair gene mutation carriers). There is limited evidence regarding the accuracy of screening tests, their acceptability, costs and availability, and agreement on whom to treat. Successful target of screening are small resectable PDAC, intraductal papillary mucinous neoplasms with high-grade dysplasia and advanced pancreatic intraepithelial neoplasia. Both magnetic resonance imaging(MRI) and endoscopic ultrasound(EUS) are employed for screening, and the overall yield for pre-malignant or malignant pancreatic lesions is of about 20% with EUS and 14% with MRI/magnetic resonance colangiopancreatography. EUS performs better for solid and MRI for cystic lesions. However, only 2% of these detected lesions can be considered a successful target, and there are insufficient data demonstrating that resection of benign or low grade lesions improves survival. Many patients in the published studies therefore seemed to have received an overtreatment by undergoing surgery. It is crucial to better stratify the risk of malignancy individually, and to better define optimal screening intervals and methods either with computerized tools or molecular biomarkers, possibly in large multicentre studies. At the moment, screening should be carefully performed within research protocols at experienced centres, offering involved individuals medical and psychological advice. | Gabriele Capurso Marianna Signoretti Roberto Valente Urban Arnelo Matthias Lohr Jan-Werner Poley Gianfranco Delle Fave Marco Del Chiaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 3 | Skeletal muscle insulin resistance after trauma:insulin signaling and glucose transport显示文摘 | Strommer L Permert J Arnelo U | 1998 | Am J Physiol1998，275，21： | 1 |
| 4 | Intraoperative endoscopic retrograde cholangiopancreatography (ERCP) to remove common bile duct stones during routine laparoscopic cholecystectomy does not prolong hospitalization: a 2-year experience显示文摘 | L. Enochsson B. Lindberg F. Swahn U. Arnelo | 2004 | Surgical Endoscopy2004，，3： | 1 |
| 5 | An antireflux stent versus conventional stents for palliation of distal esophageal or cardia cancer: a randomized clinical study显示文摘 | WENGER U JOHNSSON E ARNELO U | 2006 | Surg Endosc2006，20，11： | 1 |
| 6 | Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport显示文摘 | STROMMER L PERMORT J ARNELO Y | 1998 | Am J Physiol1998，275，2： | 1 |
| 7 | Skeletal muscle insulin resistance after trauma:insulin signaling and glucose transport显示文摘 | Strommer L Permert J Arnelo U | 1998 | Am J Physiol1998，275，： | 1 |
| 8 | Ten years of Swedish experience with intraductal electrohydraulic lithotripsy and laser lithotripsy for the treatment of difficult bile duct stones:an effective and safe option for octogenarians显示文摘 | Swahn F Edlund G Enochsson L Svensson C Lindberg B Arnelo U | 2010 | Surg Endosc2010，24，5： | 1 |
| 9 | Skeletal muscle insulin resistance after trauma:insulin signaling and glucose transport显示文摘 | Strmmer L Permert J Arnelo U | 1998 | Am J Physiol1998，275，21： | 1 |
| 10 | Comparison of Preoperative Conference-Based Diagnosis with Histology of Cystic Tumors of the Pancreas显示文摘 | Marco Del Chiaro Ralf Segersv?rd Raffaella Pozzi Mucelli Elena Rangelova Nikolaos Kartalis Christoph Ansorge Urban Arnelo John Blomberg Matthias L?hr Caroline Verbeke | 2014 | Annals of Surgical Oncology2014，，5： | 1 |
| 11 | Skeletal muscle insulin resistance after trauma:insulin signaling and glucose transport显示文摘 | Strommer L Permert J Arnelo U | 1998 | Am J Physiol1998，275，21： | 1 |
| 12 | Preoperative feeding does not reverse postoperative insulin resistance in skeletal muscle in the rat显示文摘 | Strommer L Isaksson B Arnelo U | 2000 | Metabolism2000，49，4： | 1 |
| 13 | Skeletal muscle insulin resistance after trauma:insulin signaling and glucose transport 显示文摘 | Strmmer L Permert J Arnelo U | 1998 | Am J Physiolo1998，275，21： | 1 |
| 14 | Intraoperative endoscopic retrograde cholangiopancreatography (ERCP) to remove common bile duct stones during routine laparoscopic cholecystectomy does not prolong hospitalization: a 2-year experience显示文摘 | L. Enochsson B. Lindberg F. Swahn U. Arnelo | 2004 | Surgical Endoscopy2004，，3： | 1 |
| 15 | Skeletal muscle insulin resistance after trauma; insulin signaling and glucose transport显示文摘 | Strommer L Permort J Arnelo Y | 1998 | Am J Physiol1998，275，2： | 1 |
| 16 | Skeletal muscle insulin resistance after trauma:insulin signaling and glucose transport显示文摘 | Permert J Arnelo U | 1998 | Am J Physiol1998，275，21： | 1 |
| 17 | Intraoperative endoscopic retrograde cholangiopancreatography (ERCP) to remove common bile duct stones during routine laparoscopic cholecystectomy does not prolong hospitalization: a 2-year experience显示文摘 | L. Enochsson B. Lindberg F. Swahn U. Arnelo | 2004 | Surgical Endoscopy2004，，3： | 1 |
| 18 | Preoperative feeding does not reverse postoperative insulin resistance in skeletal muscle in the rat显示文摘 | Strommer L Isaksson B Arnelo U | 2000 | Metabolism2000，49，4： | 1 |
| 19 | Gastrointestinal growth factors and pancreatic islet hormones during postoperative IGF-I supplementation in man显示文摘 | Leinsk6ld T Adrian TE Arnelo U | 2010 | J Endocrinal2010，167，2： | 1 |
| 20 | Intraoperative endoscopic retrograde cholangiopancreatography (ERCP) to remove common bile duct stones during routine laparoscopic cholecystectomy does not prolong hospitalization: a 2-year experience显示文摘 | L. Enochsson B. Lindberg F. Swahn U. Arnelo | 2004 | Surgical Endoscopy2004，，3： | 1 |
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