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| 1 | Hepatoprotective effects of S-adenosyl-L-methionine against alcohol-and cytochrome P450 2E1-induced liver injury显示文摘S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection. | Arthur I Cederbaum | 2010 | World Journal of Gastroenterology2010，16，11： | 24 |
| 2 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | CYP2E1 and oxidative liver in- jury by alcohol显示文摘 | Yongke Lu Arthur I Cederbanm | 2008 | Free Radic Biol Med2008，44，5： | 1 |
| 5 | Long QT syndrome: insights into the mechanisms of cardiac arrhythmias 显示文摘 | Rnlx+rt S Kass I Arthur JM | 2003 | J Clln Invest2003，112，6： | 1 |
| 6 | Oxidative stress mediated toxic- ity exerted by ethanol-inducible CYP2E1 显示文摘 | Defeng Wu Arthur I Cederbaum | 2005 | Toxicol Appl Phar- macol2005，207，2： | 1 |
| 7 | Steatohepatitis in obese individuals显示文摘 | Wael I Youssef Arthur J McCullough | 2002 | Best Practice & Research Clinical Gastroenterology2002，，5： | 1 |
| 8 | Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo显示文摘 | Olga Garaschuk Ruxandra I Milos Arthur Konnerth | | 0，，01： | 1 |
| 9 | A review on the phytoeonstituents and related medicinal properties of plants in the As- teraceae family 显示文摘 | Aehika J I Arthur D E Gerald I | 2014 | Journal of Applied Chemistry2014，7，8： | 1 |
| 10 | Time course characteristics of acute tolerance development to continuously infused alfentanil in rats 显示文摘 | Kissin I Lee SS Arthur CR | 2011 | Anesth Analg2011，83，2： | 1 |
| 11 | Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency显示文摘 | Yongke L U Pengfei G Arthur I C | 2008 | Toxicology2008，，252： | 1 |
| 12 | Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2El mediated toxicity in HepG2 cells through sustained activation of the p38 MAPK pathway显示文摘 | APARAJITA D ARTHUR I C | 2007 | Arch Biochem Biophys2007，461，2： | 1 |
| 13 | Disruption of FEM1C-W gene in zebra finch evolutionary insights on avian ZW genes 显示文摘 | Yuichiro I Kathy K Arthur P A | 2009 | Chromosoma2009，118，3： | 1 |
| 14 | Prognostic factors,recurrence,and survival in TCC of the upper urinary tract:A 30-year experience in 252 patients显示文摘 | Sean W Arthur I | 1998 | Urology1998，52，4： | 1 |
| 15 | The role of the intestinal microflora for the development of the immune system in early childhood显示文摘 | Arthur O Erika I Seppo S | 2002 | Eu- rop J Nutr2002，41，1： | 1 |
| 16 | Assessing impacts of intro-duced aquaculture species on native fish communities:Nile tilapia andmajor carps in SE Asian freshwaters显示文摘 | Arthur R I Lorenzen K Homekingkeo P | 2010 | Aquaculture2010，299，1234： | 1 |
| 17 | An optimization method for load management显示文摘 | Cohen Arthur I Wang Connie C | 1988 | IEEE Trans on Power Systems1988，3，2： | 1 |
| 18 | Cederbaum CYP2E1 and Oxidative Liver Injury by Alcohol显示文摘 | Yongke Lu Arthur I | 2008 | Free Radio Biol Med2008，44，5： | 1 |
| 19 | Fire-danger meters expressed as equations显示文摘 | Noble I G AM Mc Arthur's | | 0，，2： | 1 |
| 20 | Postpartum depres- sion and related psychosocial variables in Hong Kong Chinese women: Finding from a prospective study 显示文摘 | Leung S S Martinson I M Arthur D | 2005 | Res in Nuts Health2005，，28： | 1 |
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