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| 1 | Cardiac rehabilitation and exercise therapy in the elderly: Should we invest in the aged?显示文摘冠的心疾病(CHD ) 是世界范围的死亡的领先的原因并且在病人之中变得逐渐地流行 65 岁以上。老病人在为复杂并发症的更高的风险并且在一个心血管的事件以后加速物理 deconditioning,特别与他们的更年轻的对应物相比。最后几十年是到与 CHD 在病人之中在死亡,锻练能力,心理风险因素,发炎,和肥胖上表明了心脏的康复(CR ) 和锻练治疗的有益的效果的多重研究的厕所。不幸地,这个领域里的可得到的数据的重要部分与更年轻的病人相关。可行解释是更老的病人在为以病人开始并且延长到医生的多重原因的这些节目是非常未被充分代表的。在这篇文章,我们将考察 CR 节目的好处在之中老,以及一些妨碍他们的参予的障碍。 | Arthur R Menezes Carl J Lavie Richard V Milani Ross A Arena Timothy S Church | 2012 | Journal of Geriatric Cardiology2012，9，1： | 25 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | Considerations for bariatric surgery in patients with cirrhosis显示文摘With the ever increasing global obesity pandemic, clinical burden from obesity related complications are anticipated in parallel. Bariatric surgery, a treatment approved for weight loss in morbidly obese patients, has reported to be associated with good outcomes, such as reversal of type two diabetes mellitus and reducing all-cause mortality on a long term basis. However, complications from bariatric surgery have similarly been reported. In particular, with the onslaught of non-alcoholic fatty liver disease(NAFLD) epidemic, in associated with obesity and metabolic syndrome, there is increasing prevalence of NAFLD related liver cirrhosis, which potentially connotes more risk of specific complications for surgery. Bariatric surgeons may encounter, either expectedly or unexpectedly, patients with non-alcoholic steatohepatitis(NASH) and NASH related cirrhosis more frequently. As such, the issues and considerations surrounding their medical care/surgery warrant careful deliberation to ensure the best outcomes. These considerations include severity of cirrhosis, liver synthetic function, portal hypertension and the impact of surgical factors. This review explores these considerations comprehensively and emphasizes the best approach to managing cirrhotic patients in the context of bariatric surgery. | George Boon-Bee Goh Philip R Schauer Arthur J McCullough | 2018 | World Journal of Gastroenterology2018，24，28： | 4 |
| 4 | Use of Anesthetic Agents in Neonates and Young Children显示文摘 | R Daniel Mellon Arthur F. Simone Bob A. Rappaport | 2007 | Anesthesia & Analgesia2007，，3： | 2 |
| 5 | Where is the global in global mental health?A call for inclusive multicultural collaboration显示文摘To the editor:Common mental health disorders,like depression and anxiety,account for 45%of the global disease burden on youths aged 15-29.1 This challenge is particularly significant in low and middle-income countries(LMICs)where risk factors such as poverty,limited treatment options and stigma restrict access to care and exacerbate the burden and magnify the impact of mental disorders.23 Given these barriers,there is an urgent need for research dedicated to expanding mental healthcare for young people in LMICs. | Tom L Osborn Akash R Wasil John R Weisz Arthur Kleinman David M Ndetei | 2020 | General Psychiatry2020，33，6： | 2 |
| 6 | Selenium, selenorpteins and health: a review显示文摘 | Brown K M Arthur J R | 2001 | Public health nutr2001，4，2： | 2 |
| 7 | Acute lung injury and the acute respiratory distress syndrome: a clinical review显示文摘 | Arthur P Wheeler Gordon R Bernard | 2007 | 2007 (9572)2007，，9572： | 2 |
| 8 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 9 | Inherent anisotropy in a sand显示文摘 | Arthur J R F Menzies B K | 1972 | Geotechnique1972，22，1： | 2 |
| 10 | Induced anisotropy in a sand显示文摘 | Arthur J R F Chua K S Dunstan T | 1977 | Geotechnique1977，27，1： | 2 |
| 11 | The path forward for bio- fuels and biomaterials显示文摘 | Arthur J R Charlotte K W Brian H D | 2006 | Science2006，311，5760： | 1 |
| 12 | Employee assistance programs: The emperor's new clothes of stress management 显示文摘 | Arthur A R | 2000 | British Journal of Guidance & Counseling2000，28，4： | 1 |
| 13 | Employee assistance programs: the emperor's new clothes of stress management? 显示文摘 | Arthur A R | 2000 | British Journal of GuidanceCounseling2000，28，4： | 1 |
| 14 | Forest floor microbial binmass across a northern hardwood successional sequence显示文摘 | Taylor L A Arthur M A Yanai R D | | 0，，03： | 1 |
| 15 | Milankovitch cycles through geologic time显示文摘 | Arthur M A Garrison R E | 1986 | Paleoceanography1986，1，4： | 1 |
| 16 | Iturin A: a potential new fungicide for stored gains显示文摘 | Klich M A Arthur K S Lax A R | 1994 | Mycopathologia1994，127，2： | 1 |
| 17 | Selenium in the immune system显示文摘 | ARTHUR J R McKENZIE R C BECKETT G J | 2003 | J Nutr2003，133，5： | 1 |
| 18 | The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells 显示文摘 | WILLIAMS M R ARTHUR J S BALENDRAN A | 2000 | Curr Biol2000，10，： | 1 |
| 19 | Selenium, selenoproteins and human health : a review显示文摘 | Brown K M Arthur J R | 2001 | Public Health Nutrition2001，26，： | 1 |
| 20 | Determination of strains in soils by X-ray method显示文摘 | ROSCOE K H ARTHUR J R F JAMES R G | 1963 | Civil Engineering (London)1963，58，685： | 1 |
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