|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high-fat diet using the collaborative cross mouse model显示文摘Background: Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes(T2 D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically highly diverse inbred mouse lines, namely collaborative cross(CC), for dissecting host susceptibility for the development of T2 D and obesity, showing significant variations following high-fat(42% fat) diet(HFD). Here, we aimed to assessing the host genetic background and sex effects on T2 D and obesity development in response to oral-mixed bacterial infection and HFD using the CC lines.Materials and Methods: Study cohort consists of 97 mice from 2 CC lines(both sexes), maintained on either HFD or Standard diet(CHD) for 12 weeks. At week 5 a group of mice from each diet were infected with Porphyromonas gingivalis(Pg) and Fusobacterium nucleatum(Fn) bacteria(control groups without infection). Body weight(BW) and glucose tolerance ability were assessed at the end time point of the experiment.Results: The CC lines varied(P <.05) at their BW gain and glucose tolerance ability(with sex effect) in response to diets and/or infection, showing opposite responses despite sharing the same environmental conditions. The combination of diet and infection enhances BW accumulation for IL1912, while restraints it for IL72. As for glucose tolerance ability, only females(both lines) were deteriorated in response to infection.Conclusions: This study emphasizes the power of the CC mouse population for the characterization of host genetic makeup for defining the susceptibility of the individual to development of obesity and/or impaired glucose tolerance. | Luna Karkar Hanifa JAbu-Toamih Atamni Asal Milhem Yael Houri-Haddad Fuad A.Iraqi | 2020 | Animal Models and Experimental Medicine2020，3，2： | 5 |
| 2 | Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines显示文摘Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.Methods:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference population.We aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial infection.The study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not infected.Body weight(BW)and results of a intraperitoneal glucose tolerance test(IPGTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp counts.Results:Polyp counts ranged between 2 and 10 per CC line.The combination of HFD and infection significantly reduced(P<.01)the colon polyp size of IL557 females to 2.5 cm 2,compared to the other groups.Comparing BW gain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the IPGTT.Conclusion:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related. | Asal Milhem Hanifa J.Abu Toamih-Atamni Luna Karkar Yael Houri-Haddad Fuad A.Iraqi | 2021 | Animal Models and Experimental Medicine2021，4，1： | 4 |
| 3 | A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes显示文摘 | Asal Ataie-Jafari Seng-Cheong Loke Asmah B. Rahmat Bagher Larijani Farzaneh Abbasi Melvin K.S. Leow Zaitun Yassin | 2013 | Clinical Nutrition2013，，： | 2 |
| 4 | Sternocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey's syndrome and facial contour deformity显示文摘 | Asal K Ksybasioglu A Inal E | 2005 | Ear Nose Throat J2005，84，3： | 1 |
| 5 | Sternocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey,s syndrome and facial contour deformity 显示文摘 | Asal K Koybasioglu A Inal E | 2005 | Ear Nose Throat J2005，84，3： | 1 |
| 6 | Zooprophylaxis as a control strategy for malaria caused by the vector Anopheles arabiensis(Diptera:Culicidae):a systematic review显示文摘Background:Zooprophylaxis is the use of wild or domestic animals,which are not the reservoir host of a given disease,to divert the blood-seeking malaria vectors from human hosts.In this paper,we systematically reviewed zooprophylaxis to assess its efficacy as a malaria control strategy and to evaluate the possible methods of its application.Methods:The electronic databases,PubMed Central^(■),Web of Science,Science direct,and African Journals Online were searched using the key terms:“zooprophylaxis”or“cattle and malaria”,and reports published between January 1995 and March 2016 were considered.Thirty-four reports on zooprophylaxis were retained for the systematic review.Results:It was determined that Anopheles arabiensis is an opportunistic feeder.It has a strong preference for cattle odour when compared to human odour,but feeds on both hosts.Its feeding behaviour depends on the available hosts,varying from endophilic and endophagic to exophilic and exophagic.There are three essential factors for zooprophylaxis to be effective in practice:a zoophilic and exophilic vector,habitat separation between human and host animal quarters,and augmenting zooprophylaxis with insecticide treatment of animals or co-intervention of long-lasting insecticide-treated nets and/or indoor residual spraying.Passive zooprophylaxis can be applied only in malaria vector control if cattle and human dwellings are separated in order to avoid the problem of zoopotentiation.Conclusions:The outcomes of using zooprophylaxis as a malaria control strategy varied across locations.It is therefore advised to conduct a site-specific evaluation of its effectiveness in vector control before implementing zooprophylaxis as the behaviour of Anopheles arabiensis mosquitoes varies across localities and circumstances. | Abebe Asale Luc Duchateau Brecht Devleesschauwer Gerdien Huisman Delenasaw Yewhalaw | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
| 7 | On fuzzy mathematical programming 显示文摘 | Tanaka H Ukuda T Asal K | 1984 | Journal of Cybernetics1984，3，4： | 1 |
| 8 | The significance of ferritin,lipid-associated sialic acid,CEA,squamous cell carcinoma (SCC) antigen,and CYFRA 21-1 levels in SCC of the head and neck显示文摘 | Inal E Lacin M Asal K | | 0，，1： | 1 |
| 9 | Sternocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey's syndrome and facial contour deformity显示文摘 | ASAL K KOYBASIOGLU A INAL E | 2005 | Ear Nose Throat2005，84，： | 1 |
| 10 | Sternocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey's syn- drome and facial contour deformity 显示文摘 | Asal K Kfiybagiolu A Inal E | 2005 | Ear Nose Throat J2005，84，3： | 1 |
| 11 | Playing Games with International Relations 显示文摘 | Asal V | 2005 | International Studies Perspectives2005，，6： | 1 |
| 12 | Stemocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey syndrome and facial contour deformity显示文摘 | Asal K Koybasioglu A Inal E | 2005 | Ear Nose Throat J2005，84，2： | 1 |
| 13 | Influence of pH, high salinity and particle concentration on stability and rheo- logical properties of aqueous suspensions of fumed silica显示文摘 | Amiri Asal Oye Gisle Sjoblom Johan | 2009 | Colloids and Surface A: Physicochemical and Engineering Aspects2009，349，13： | 1 |
| 14 | Ameloblastic carcinomacontaining melanocyte and melanin pigment in the mandible: acase report and review of the literature 显示文摘 | Uzum N Akyol G Asal K | 2005 | J Oral Pathol Med2005，34，10： | 1 |
| 15 | Playing Games with International Relations 显示文摘 | Asal V | 2005 | International Studies Perspectives2005，，6： | 1 |
| 16 | Power Play: Mediation in Symmetric and Asymmetric International Crises显示文摘 | David Quinn Jonathan Wilkenfeld Kathleen Smarick Victor Asal | 2006 | International Interactions2006，，4： | 1 |
| 17 | Sternocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey' s syndrome and facial contour deformity 显示文摘 | Asal K Koybasioglu A Inal E | 2005 | Ear Nose Throat J2005，84，3： | 1 |
| 18 | Finite cover method for linear and non-linear analyses of heterogeneous solids显示文摘 | TERADA K ASAL M YAMAGISHI M | 2003 | International Journal for Numerical Methods in Engineering2003，58，9： | 1 |
| 19 | Electrical characterization of Pt/AlGaN/GaN Schottky diodes grown using AlN template and their application to hydrogen gas sensors 显示文摘 | MIYOSHI M KURAOKO Y ASAl K | 2007 | J Vac Sci Technol: B2007，25，4： | 1 |
| 20 | Dispersion of filler and the electrical conductivity of polymer blends filled with carbon black显示文摘 | Sumita M Sakata K Asal S | 1991 | PolymerBulletin1991，25，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员