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| 1 | Epidemiology of lung cancer and approaches for its prediction:a systematic review and analysis显示文摘Background: Owing to the use of tobacco and the consumption of alcohol and adulterated food, worldwide cancer incidence is increasing at an alarming and frightening rate. Since the last decade of the twentieth century, lung cancer has been the most common cancer type. This study aimed to determine the global status of lung cancer and to evaluate the use of computational methods in the early detection of lung cancer.Methods: We used lung cancer data from the United Kingdom(UK), the United States(US), India, and Egypt. For statistical analysis, we used incidence and mortality as well as survival rates to better understand the critical state of lung cancer.Results: In the UK and the US, we found a significant decrease in lung cancer mortalities in the period of 1990–2014, whereas, in India and Egypt, such a decrease was not much promising. Additionally, we observed that, in the UK and the US, the survival rates of women with lung cancer were higher than those of men. We observed that the data mining and evolutionary algorithms were efficient in lung cancer detection.Conclusions: Our findings provide an inclusive understanding of the incidences, mortalities, and survival rates of lung cancer in the UK, the US, India, and Egypt. The combined use of data mining and evolutionary algorithm can be efficient in lung cancer detection. | Ashutosh Kumar Dubey Umesh Gupta Sonal Jain | 2016 | Chinese Journal of Cancer2016，35，9： | 37 |
| 2 | A systematic investigation of secondary phase dissolution in Mg-Sn alloys显示文摘As-cast Mg-Sn alloys(3,6,and 9 wt%Sn)were solution treated at 653,703 and 753 K(380,430 and 480℃)for 1,4,8,12 and 24 h to determine the variation of secondary phase with respect to Sn content,temperature and time.Mg-3 wt%Sn exhibits Mg2Sn dissolution at all solution treatment temperatures whereas Mg-6 and 9 wt%Sn alloy displays Mg2Sn reprecipitation and dissolution depending on the heat treatment temperature.In addition,a combined mathematical model that predicts the secondary phase dissolution and solute redistribution as a function of temperature and time is presented in this work.This model is a significant improvement compared to the previous studies where the dissolution and homogenization processes are considered independently.The effect of grain size and solute mobility upon the dissolution and homogenization kinetics is discussed as well. | Arushi Dev Niladri Naskar Nishant Kumar Ashutosh Jena Manas Paliwal | 2019 | Journal of Magnesium and Alloys2019，7，4： | 5 |
| 3 | A novel approach for part family formation using K-means algorithm显示文摘The reconfigurable manufacturing system(RMS) is the next step in manufacturing,allowing the production of any quantity of highly customized and complex parts together with the benefits of mass production.In RMSs,parts are grouped into families,each of which requires a specific system configuration.Initially system is configured to produce the first family of parts.Once it is finished,the system will be reconfigured in order to produce the second family,and so forth.The effectiveness of a RMS depends on the formation of the optimum set of part families addressing various reconfigurability issues.The aim of this work is to establish a methodology for grouping parts into families for effective working of RMS.The methodology carried out in two phases. In the first phase,the correlation matrix is used as similarity coefficient matrix.In the second phase,agglomerative hierarchical K-means algorithm is used for the parts family formation resulting in an optimum set of part families for reconfigurable manufacturing system. | Ashutosh Gupta P.K.Jain Dinesh Kumar | 2013 | Advances in Manufacturing2013，1，3： | 4 |
| 4 | Ayurvedic concept of Shatkriyakala:a traditional knowledge of cancer pathogenesis and therapy显示文摘The term Kriyakala refers to the recognition of the stage of a disease's progress,which helps to determine appropriate measure to correct the imbalance in Doshas(biological factors).It is a compound expression,comprised of Kriya and Kala,where Kriya means the choice to treatment(medicine,food and daily-routine) used to improve the disturbance in Doshas,and Kala refers to the stage of progress of a disease.Sushruta,an ancient Indian surgeon,has described the concept of Kriyakala in Varnaprashnadhyaya,an ancient Vedic Sanskrit text,which seeks to explain the incidence of Varnas in terms of Doshic disturbances.Varna,in modern parlance,may be described as an inflammatory process that may lead ulceration and chronic inflammation,promoting all stages of carcinogenesis.Abnormal interactions between Prakriti(genotype) and environmental factors vitiate the Doshas and impair immunity,which can lead to aberrant cell growth and cancer.Moreover,the interaction between vitiated Doshas and weak Dhatus(body tissues) manifests as cancers of a specific organ.Shatkriyakala(six stages of progress of a disease),on the other hand,provides a framework to assess the cancer and its pathogenesis in different stages.According to Ayurvedic concepts,all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas,rejuvenating Dhatus and restoring immunity in cancer patients.The present review describes the six stages of Shatkhyakala in detail,with an emphasis on research areas to validate the concept of Shatkhyakala.This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages. | Ashutosh Chauhan Deepak Kumar Semwal Satyendra Prasad Mishra Ruchi Badoni Semwal | 2017 | Journal of Integrative Medicine2017，15，2： | 3 |
| 5 | The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-lp transcription and processing in monocytes显示文摘 | Ankita Singh Vishal Singh Rajiv L. Tiwari Tulika Chandra Ashutosh Kumar Madhu Dikshit Manoj K. Barthwal | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 6 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 7 | Emerging industrial applications of microalgae:challenges and future perspectives显示文摘Microalgae are unicellular photosynthetic organisms that have been recently attracted potential interests and have applications in food,nutraceuticals,pharmaceuticals,animal feed,cosmetics,and biofertilizers industry.Microalgae are rich in a variety of high-value bioactive compounds which have potential benefits on human health and can be used for the prevention and curing of many disease conditions.But scale-up and safety issues remain a major challenge in the commercialization of microalgal products in a cost-effective manner.However,techniques have been developed to overcome these challenges and successfully selling the products derived from microalgae as food,cosmetics and pharmaceutical industries.Microalgae are rich in many nutrients and can be used for the production of functional food and nutraceuticals,safety and regulatory issues are major concerns and extensive research is still needed to make microalgae a commercial success in the future.Many practical difficulties are involved in making the microalgal food industry commercially viable.The present review focuses on the industrial applications of microalgae and the challenges faced during commercial production. | Aswathy Udayan Ashutosh Kumar Pandey Pooja Sharma Nidhin Sreekumar Sunil Kumar | 2021 | Systems Microbiology and Biomanufacturing2021，1，4： | 2 |
| 8 | Comparison of surgically induced astigmatism in various incisions in manual small incision cataract surgery显示文摘AIM: To determine the surgically induced astigmatism(SIA) in Straight, Frown and Inverted V shape(Chevron)incisions in manual small incision cataract surgery(SICS).METHODS: A prospective cross sectional study was done on a total of 75 patients aged 40 y and above with senile cataract. The patients were randomly divided into three groups(25 each). Each group received a particular type of incision(Straight, Frown or Inverted V shape incisions). Manual SICS with intraocular lens(IOL)implantation was performed. The patients were compared4 wk post operatively for uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA) and SIA. All calculations were performed using the SIA calculator version 2.1, a free software program. The study was analyzed using SPSS version 15.0 statistical analysis software.RESULTS: The study found that 89.5% of patients in Straight incision group, 94.2% in Frown incision group and 95.7% in Inverted V group attained BCVA post-operatively in the range of 6/6 to 6/18. Mean SIA was minimum(-0.88 ±0.61 D ×90 degrees) with Inverted V incision which was statistically significant.CONCLUSION: Inverted V(Chevron) incision gives minimal SIA. | Nidhi Jauhari Deepak Chopra Rajan Kumar Chaurasia Ashutosh Agarwal | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 2 |
| 9 | Ethanol steam reforming study over ZSM-5 supported cobalt versus nickel catalyst for renewable hydrogen generation显示文摘The renewable hydrogen generation through ethanol steam reforming is one of the anticipated areas for sustainable hydrogen generation. To elucidate the role of Ni and Co with ZSM-5 support, catalysts were prepared by wet impregnation method and ethanol steam reforming(ESR) was performed. The catalysts were characterized by HR-XRD, ATR–FTIR, HR-SEM, TEM with SAED, EDAX, surface area analyzer and TPR. It had shown complete ethanol conversion at 773 K, but the selectivity in hydrogen generation was found higher for 10% Ni/ZSM-5 catalyst as compared to 10% Co/ZSM-5. The 10% Ni/ZSM-5 catalyst has about 72% hydrogen selectivity at temperature 873 K. It indicates that Ni is a more sustainable catalyst as compared to Co with ZSM-5 support for ESR. The C_2H_4 was found major undesirable products up to 823 K temperature. Nevertheless, the 10% Ni/ZSM-5 catalyst had shown its stability for high temperature(873 K) ESR performance. | Ashutosh Kumar Ram Prasad Yogesh Chandra Sharma | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 2 |
| 10 | Electron Paramagnetic Resonance and Optical Absorption of VO2+Doped Ammonium Selenate Single Crystals显示文摘An electron paramagnetic resonance study of vanadyl ions doped in ammonium selenate single crystals is carried out at room temperature.It is found that the VO^(2+)ion takes up an interstitial site.The spin Hamiltonian parameters obtained from the crystal rotations are g‖=1.9576±0.0002,g⊥=1.9889±0.0002,A‖=203±2 G,A⊥=78±2 G.An optical absorption study is also carried out to evaluate various bonding parameters.On the basis of these parameters the nature of bonding in the complex is discussed. | Ram Kripal Ashutosh Kumar Shukla | 2011 | Chinese Physics Letters2011，28，3： | 2 |
| 11 | Identification,synthesis and characterization of an unknown process related impurity in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS,~1H,^(13)C and ~1H-~1H COSY NMR显示文摘A new impurity was detected during high performance liquid chromatographic(HPLC) analysis of eslicarbazepine acetate active pharmaceutical ingredient.The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer(LC/ESI-IT/MS) analysis.Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using ~1H,^(13)C nuclear magnetic resonance spectrometry(NMR),~1H-~1H correlation spectroscopy(COSY) and infrared spectroscopy(IR).Based on the spectroscopic and spectrometric data,unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate. | Saji Thomas Saroj Kumar Paul Subhash Chandra Joshi Vineet Kumar Ashutosh Agarwal Dharam Vir | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 2 |
| 12 | Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain显示文摘Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that limit the pathological changes and improve the behavioral outcome have been well explained in different experimental models of neuropathy but translation of such strategies to clinics has been disappointing. Experimental evidences revealed the role of free radicals, especially peroxynitrite after the nerve injury. They provoke oxidative DNA damage and consequent over-activation of the poly(ADP-ribose) polymerase(PARP) upregulates pro-inflammatory pathways, causing bioenergetic crisis and neuronal death. Along with these changes, it causes mitochondrial dysfunction leading to neuronal apoptosis. In related preclinical studies agents that neutralize the free radicals and pharmacological inhibitors of PARP have shown benefits in treating experimental neuropathy. This article reviews the involvement of PARP over-activation in trauma induced neuropathy and therapeutic significance of PARP inhibitors in the experimental neuropathy and neuropathic pain. | Prashanth Komirishetty Aparna Areti Ranadeep Gogoi Ramakrishna Sistla Ashutosh Kumar | 2016 | Neural Regeneration Research2016，11，10： | 2 |
| 13 | Thermoelectric properties of high-entropy rare-earth cobaltates显示文摘High-entropy concept introduced with a promising paradigm to obtain exotic physical properties has motivated us to explore the thermoelectric properties of Sr-substituted high-entropy rare-earth cobaltates i.e.,(LaNdPrSmEu)_(1-x)Sr_(x)CoO_(3)(0≤x≤0.10).The structural analysis of the samples,synthesized using the standard solid-state route,confirms the orthorhombic structure with the Pbnm space group.The Seebeck coefficient and electrical resistivity decrease with rising Sr concentration as well as with an increase in temperature.The multiple A-site ions in high-entropy rare-earth cobaltates result in an improved Seebeck coefficient(α)compared to La_(0.95)Sr_(0.05)CoO_(3),associated with a decrease in the Cosingle bondOsingle bondCo bond angle,which further enhances the power factor.The random distribution of cations at the rare-earth site results in a significant lowering of phonon thermal conductivity.As a result,a maximum figure of merit(zT)of 0.23 is obtained at 350K for(LaNdPrSmEu)_(0.95)Sr_(0.05)CoO_(3),which is one of the highest values of zT reported at this temperature for oxide materials.This study shows promise to decouple thermoelectric parameters using the high-entropy concept in several materials. | Ashutosh Kumar Diana Dragoe David Berardan Nita Dragoe | 2023 | Journal of Materiomics2023，9，1： | 1 |
| 14 | Development and characterization of the menthofuran-rich inter-specific hybrid peppermint variety CIMAP-Patra显示文摘 | Birendra Kumar Ashutosh K. Shukla A. Samad | 2014 | Molecular Breeding2014，，2： | 1 |
| 15 | Modelling the slab stack shuffling problem in developing steel rolling schedules and its solution using improved parallel genetic algorithms 显示文摘 | Kumar Ashutosh Singh Srinivas Tiwari M K | 2004 | International Journal of Production Eco- nomics2004，91，2： | 1 |
| 16 | Use of nitric oxide inhalation in chronic obstructive pulmonary disease显示文摘 | Kumar Ashutosh Kishor Phadke | 2000 | Thorax2000，55，： | 1 |
| 17 | Determination of vitamin C in chemical, pharmaceutical and biological sampies by speetrophotometrie titrimetry with o - diaeetoxyiodobenzoate 显示文摘 | Ashutosh Srivastava Sunil Kumar Singh | 1988 | Analyst1988，113，： | 1 |
| 18 | Varna-based optimization:a novel method for capacitated controller placement problem in SDN显示文摘Recently,software defined networking(SDN)is a promising paradigm shift that decouples the control plane from the data plane.It can centrally monitor and control the network through softwarization,i.e.,controller.Multiple controllers are a necessity of current SDN based WAN.Placing multiple controllers in an optimum way is known as controller placement problem(CPP).Earlier,solutions of CPP only concentrated on propagation latency but overlooked the capacity of controllers and the dynamic load on switches,which is a significant factor in real networks.In this paper,we develop a novel optimization algorithm named varna-based optimization(VBO)and use it to solve CPP.To the best of our knowledge,this is the first attempt to minimize the total average latency of SDN along with the implementation of TLBO and Jaya algorithms to solve CPP for all twelve possible scenarios.Our experimental results show that TLBO outperforms PSO,and VBO outperforms TLBO and Jaya algorithms in all scenarios for all topologies. | Ashutosh Kumar SINGH Saurabh MAURYA Shashank SRIVASTAVA | 2020 | Frontiers of Computer Science2020，14，3： | 1 |
| 19 | Species identification and authentication of tissues of animal origin using mitochondrial and nuclear markers显示文摘 | Gurdeep Rastogi Mahesh S. Dharne Sandeep Walujkar Ashutosh Kumar Milind S. Patole Yogesh S. Shouche | 2007 | Meat Science2007，，4： | 1 |
| 20 | Balancing Inverted Pendulum by Angle Sensing Using Fuzzy Logic Supervised PID Controller Optimized by Genetic Algorithm显示文摘 | Agarwal Ashutosh K Kumar Sanjeev | 2011 | Sensors & Transducers2011，，10： | 1 |
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