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| 1 | Effect of Graphene Nanoplatelets addition on mechanical properties of pure aluminum using a semi-powder method显示文摘In recent years, graphene has attracted considerable research interest in all fields of science due to its unique properties. Its excellent mechanical properties lead it to be used in nano-composites for strength enhancement. This paper reports an Aluminum–Graphene Nanoplatelets(Al/GNPs)composite using a semi-powder method followed by hot extrusion. The effect of GNP nano-particle integration on tensile, compressive and hardness response of Al is investigated in this paper. It is demonstrated that 0.3 wt% Graphene Nanoplatelets distributed homogeneously in the matrix aluminum act as an effective reinforcing filler to prevent deformation. Compared to monolithic aluminum(in tension), Al–0.3 wt% GNPs composite exhibited higher 0.2% yield strength(+14.7%), ultimate tensile strength(+11.1%) and lower failure strain( -40.6%). Surprisingly, compared to monolithic Al(in compression), Al–0.3 wt% GNPs composite exhibited same 0.2% compressive yield strength and lower ultimate compression strength(- 7.8%),and lower failure strain(- 20.2%). The Al–0.3 wt% GNPs composite exhibited higher Vickers hardness compared to monolithic aluminum(+11.8%).Scanning electron microscopy(SEM), Energy-Dispersive X-ray Spectroscopy(EDS) and X-ray diffraction(XRD) were used to investigate the surface morphology, elemental percentage composition, and phase analysis, respectively. | Muhammad Rashad Fusheng Pan Aitao Tang Muhammad Asif | 2014 | Progress in Natural Science:Materials International2014，24，2： | 52 |
| 2 | 典型切削机床能耗模型的研究现状及发展趋势显示文摘机床作为机械制造行业的'母机',数量大、能耗高、效率低。近年来,学者们为建立精确的机床能耗模型已做大量工作。针对典型切削机床能耗的建模现状,从切削单元能耗、加工阶段整机能耗、工艺单元能耗三个层次进行综合分析。进而从节能优化、产品绿色性评估、企业资源配置、机床绿色设计四方面对机床能耗模型的应用进行论述。目前,机床能耗的建模逐渐面向高端数控机床,建模的目标性更加明确,与工业应用的结合也使得模型的实用价值不断提升。 | 李涛 孔露露 张洪潮 ASIF Iqbal | 2014 | 机械工程学报2014，50，7： | 40 |
| 3 | 油罐车火灾下钢-混凝土组合梁桥结构响应研究显示文摘采用数值模拟方法,研究钢-混凝土组合梁式公路桥在大型车辆火灾下的结构响应,考察桥梁形式、火灾工况及荷载比的影响。首先以规范给定的烃类火灾升温曲线及CFD模拟实际油罐车火灾所得到的升温曲线作为温度边界条件,用ABAQUS建立了8个有限元模型进行计算,得出了构件内部温度场,发现实际火灾下斜交桥受火跨最高温度低于正交桥的,但整体温度更高;实际火灾较规范火灾下结构升温更快,最高温度更高;随后以受火升温结果作为温度荷载,通过恒载升温分析,考察了共计18个案例的结构响应,发现正交桥和斜交桥在火灾下的破坏模式有较大差别,前者出现不适于继续承载的变形,同时伴随着远端支座腹板屈曲的局部破坏,而后者主要体现为远端支座腹板严重屈曲;最后提出了针对钢-混凝土组合梁桥抗火措施和设计思路的建议。 | 李国强 许炎彬 Asif Usmani | 2016 | 防灾减灾工程学报2016，36，3： | 18 |
| 4 | Investigation on microstructural, mechanical and electrochemical properties of aluminum composites reinforced with graphene nanoplatelets显示文摘In present study,the microstructure,mechanical and electrochemical properties of aluminum-graphene nanoplatelets(GNPs) composites were investigated before and after extrusion.The contents of graphene nanoplatelets(GNPs) were varied from 0.25 to 1.0 wt.%in aluminum matrix.The composites were fabricated thorough powder metallurgy method,and the experimental results revealed that Al-0.25%GNPs composite showed better mechanical properties compared with pure Al,Al-0.50%GNPs and Al-0.1.0%GNPs composites.Before extrusion,the Al-0.25%GNPs composite showed ~13.5%improvement in ultimate tensile strength(UTS) and ~50%enhancement in failure strain over monolithic matrix.On the other hand,Al-0.50%GNPs and Al-0.1.0%GNPs composites showed the tensile strength lower than monolithic matrix.No significant change was observed in 0.2%yield strength(YS) of the composites.However,the extruded materials showed different trends.The0.2%YS of composites increased with increase in GNPs filler weight fractions.Surprisingly,UTS of composites with 0.25 and 0.50%GNPs was lower than monolithic matrix.The failure strain of the baseline matrix was enhanced by ~46%with 0.25%graphene nanoplatelets.The superior mechanical properties(in terms of failure strain) of the Al-0.25%GNPs composite maybe attributed to 2-D structure,high surface area and curled nature of graphene.In addition,the corrosion resistance of pure Al and its composites reinforced with 0.5 and 1.0 wt%GNPs was also investigated.It was found that the corrosion rate increased considerably by the presence of GNPs. | Muhammad Rashad Fusheng Pan Zhengwen Yu Muhammad Asif Han Lin Rongjian Pan | 2015 | Progress in Natural Science:Materials International2015，25，5： | 17 |
| 5 | A review on therapeutic potential of Nigella sativa:A miracle herb显示文摘Nigella sativa(N.sativa)(Family Ranunculaceae)is a widely used medicinal plant throughout the world.It is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and Siddha.Seeds and oil have a long history of folklore usage in various systems of medicines and food.The seeds of N.saliva have been widely used in the treatment of different diseases and ailments.In Islamic literature,it is considered as one of the greatest forms of healing medicine.It has been recommended for using on regular basis in Tibb-e-Nabwi(Prophetic Medicine).It has been widely used as antihypertensive,liver tonics,diuretics,digestive,anti-diarrheal,appetite stimulant,analgesics,anti-bacterial and in skin disorders.Extensive studies on N.sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic,anticancer,immunomodulator,analgesic,antimicrobial,anti-inflammatory,spasmolytic,bronchodilator,hepato-protective,renal protective,gaslro-prolective,antioxidant properties,etc.Due to its miraculous power of healing,N.sativa has got the place among the top ranked evidence based herbal medicines.This is also revealed that most of the therapeutic,properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil.The present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics,chemical composition and pharmacological activities of the seeds of this plant. | Aftab Ahmad Asif Husain Mohd Mujeeb Shah Alam Khan Abul Kalam Najmi Nasir Ali Siddique Zoheir A.Damanhouri Firoz Anwar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 16 |
| 6 | 上海市胆道癌诊治情况的调查和分析显示文摘目的评估上海市胆道癌的诊治情况.方法对上海市区1997年6月至2001年5月4年间年龄在35~74岁的658例胆道癌新病例进行流行病学调查,对收集到的390例胆囊癌、195例胆管癌和73例壶腹癌的临床资料进行分析.结果资料显示,胆道癌好发于老年人;胆囊癌男女之比为1∶ 2.61;胆管癌和壶腹癌则男性略多于女性.胆囊癌、胆管癌和壶腹癌分别有68.5%、43.1%和22.4%的患者合并胆结石.胆囊癌的B超诊断准确率为63.1%,意外胆囊癌占20%,ⅣA和ⅣB期胆囊癌占43.6%.胆管癌和壶腹癌的误诊率较高,分别为19.1%和47.1%,且就诊时大多数患者已出现黄疸.69例(18.2%)胆囊癌、50例(25.6%)胆管癌和54例(74%)壶腹癌行根治性切除术,术后1、3、5年生存率分别为58.5%、42.8%、40.7%, 58%、28.3%、11.1%和81.5%、39.2%、26.9%.79例胆管癌行姑息性引流术,大多数患者在术后1年内死亡.38例胆管癌植入金属内支架或塑料内支撑管,平均生存期约7个月.结论胆道癌的早期诊断仍较困难;应重视胆囊癌手术方法的规范化;怀疑胆管癌而无手术禁忌证宜手术探查;壶腹癌宜行胰十二指肠切除术. | 王炳生 秦净 邓杰 张柏和 韩天权 沈铭昌 Asif Rashid Ann W Hsing 高玉堂 | 2005 | 中华外科杂志2005，43，7： | 15 |
| 7 | Formation-Containment Control Using Dynamic Event-Triggering Mechanism for Multi-Agent Systems显示文摘The paper proposes a novel approach for formationcontainment control based on a dynamic event-triggering mechanism for multi-agent systems.The leader-leader and follower-follower communications are reduced by utilizing the distributed dynamic event-triggered framework.We consider two separate sets of design parameters:one set comprising control and dynamic event-triggering parameters for the leaders and a second set similar to the first one with different values for the followers.The proposed algorithm includes two novel stages of codesign optimization to simultaneously compute the two sets of parameters.The design optimizations are convex and use the weighted sum approach to enable a structured trade-off between the formation-containment convergence rate and associated communications.Simulations based on non-holonomic mobile robot multi-agent systems quantify the effectiveness of the proposed approach. | Amir Amini Amir Asif Arash Mohammadi | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，5： | 15 |
| 8 | 上海市胆囊癌诊治现状分析显示文摘目的分析上海地区胆囊癌的诊治现状.方法对1997年6月至2001年5月间上海市390例确诊胆囊癌的病例进行临床病理分析.结果 390例胆囊癌中男108例、女282例,平均年龄64岁,发病率随年龄的增加而上升.有261例(66.9%)合并胆囊结石.主要临床表现为中上腹不适(88.0%)、食欲减退(61.5%)、体重下降(44.4%).行单纯胆囊切除术187例(56.0%)、胆囊癌根治性切除术65例(19.5%)、胆囊癌扩大根治性切除术7例(2.1%)、剖腹探查术74例(22.2%).322例获得病理诊断,腺癌为226例(70.2%)最为多见.0~Ⅳb期的5年生存率分别是100%、58.7%、40.2%、9.2%、13.5%和7.1%,根治性切除、胆囊切除和未切除者的5年生存率分别是40.7%、31.3%和2.6% (P<0.01).结论提高胆囊癌的早期诊断率,规范胆囊癌的治疗方法是提高疗效的关键. | 秦净 王炳生 韩天权 张柏和 沈铭昌 邓杰 Asif Rashid Ann W Hsing 高玉堂 | 2005 | 中华普通外科杂志2005，20，9： | 14 |
| 9 | Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells显示文摘Artemisinin 对药抵抗的疟疾的寄生虫是高度有效的,它将近影响全球人口和杀死的一半 > 500 000 个人每年。artemisinin 的主要费用是过去常从 Artemisia annua 提取并且净化这药的昂贵的过程。这显然不必要的步的消除将在地方性的区域使这有势力抗疟药药买得起到全球人口生活。这里,我们报导了非蛋白质药 artemisinin biosynthesized 的口头的交货(0.8 mg/g 干燥重量) 在在由设计二的烟草的临床上有意义的层次,新陈代谢的小径指向了到三不同细胞的分隔空间(叶绿体,原子核,和线粒体) 。二倍地转基因的线显示出 isopentenyl 焦磷酸盐的三方面的改进,并且指向 AACPR, DBR2,和 CYP71AV1 到叶绿体导致了更高的表示和 dihydroartemisinic 酸的有效相片氧化到 artemisinin。从转基因的烟草植物的叶子的部分净化的摘录在变形体感染 falciparum 的红血房间的 vitro 生长前进禁止了。artemisinin 减少了的整个未经触动的植物房间 bioencapsulating 的口头的喂在与商业药比较的质问老鼠的 parasitemia 层次。如此的新奇 synergistic 途径应该通过可食的植物的新陈代谢的工程便于 artemisinin 和另外的药的便宜生产和交货。 | Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra Asif Mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 | 2016 | Molecular Plant2016，9，11： | 14 |
| 10 | Is it time to replace propranolol with carvedilol for portal hypertension?显示文摘Beta-adrenergic receptor antagonists(β-blockers) have been well established for use in portal hypertension for more than three decades. Different Non-selective β-blockers like propranolol, nadolol, timolol, atenolol, metoprolol and carvedilol have been in clinical practice in patients with cirrhosis. Carvedilol has proven 2-4 times more potent than propranolol as a beta-receptor blocker in trials conducted testing its efficacy for heart failure. Whether the same effect extends to its potency in the reduction of portal venous pressures is a topic of on-going debate. The aim of this review is to compare the hemodynamic and clinical effects of carvedilol with propranolol, and attempt assess whether carvedilol can be used instead of propranolol in patients with cirrhosis. Carvedilol is a promising agent among the beta blockers of recent time that has shown significant effects in portal hypertension hemodynamics. It has also demonstrated an effective profile in its clinical application specifically for the prevention of variceal bleeding. Carvedilol has more potent desired physiological effects when compared to Propranolol. However, it is uncertain at the present juncture whether the improvement in hemodynamics also translates into a decreased rate of disease progression and complications when compared to propranolol. Currently Carvedilol shows promise as a therapy for portal hypertension but more clinical trials need to be carried out before we can consider it as a superior option and a replacement for propranolol. | Shahab Abid Saadat Ali Muhammad Asif Baig Anam Akbar Waheed | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 13 |
| 11 | Narrow band imaging with magnification for the diagnosis of lesions in the upper gastrointestinal tract显示文摘Endoscopy plays an important role in the diagnosis and management of gastrointestinal(GI)tract disorders.Chromoendoscopy has proven to be superior to white light endoscopy for early detection of various GI lesions.This has however been fraught with problems.The use of color stains,time taken to achieve an effect and the learning curve associated with the technique has been some of the pitfalls.Narrow band imaging(NBI)particularly in combination with magnifying endoscopy may allow the endoscopist to accomplish a fairly accurate diagnosis with good histological correlation similar to results achieved with chromoendoscopy.Such enhanced detection of pre-malignant and early neoplastic lesions in the gastrointestinal tract should allow better targeting of biopsies and could ultimately prove to be cost effective.Various studies have been done demonstrating the utility of this novel technology.This article will review the impact of NBI in the diagnosis of upper gastrointestinal tract disorders. | Rajvinder Singh Asif Hussain Cheong Kuan Loong | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，12： | 12 |
| 12 | 土地利用驱动的土壤性状变化影响微生物群落结构和功能显示文摘微生物在调节陆地生态系统地球化学循环过程中具有重要作用。土地利用方式改变显著影响土壤微生物群落结构和功能,但对土地利用驱动的土壤性状变化与微生物群落结构和功能关系的研究相对匮乏。依托长期定位监测试验(始于1984年),通过16S rRNA基因片段和ITS高通量测序,研究了土地利用方式(裸地、农田、草地)驱动的土壤碳氮变化对微生物群落结构和功能的影响。结果表明:对于细菌群落而言,裸地中α-多样性最高、其次是草地、农田中最低,农田和草地中细菌优势菌群变形菌(Proteobacteria)和放线菌门(Actinobacteria)相对丰度较裸地低4.5%、3.9%和5.5%、3.8%;对于真菌群落而言,裸地子囊菌门(Ascomycota)相对丰度最高、农田次之、草地最低;化能异养型、好氧化能异养型细菌相对丰度裸地显著高于农田和草地(P<0.05),而硝化型和好氧氨氧化型细菌裸地显著低于农田和草地(P<0.05);腐生型真菌相对丰度大小排序为:裸地>农田>草地。细菌群落变化主要与土壤容重、全氮、矿质氮、C∶N比和微生物量碳有关,而真菌群落与土壤矿质氮有关。细菌和真菌功能菌群主要受土壤容重、土壤有机碳、土壤全氮、C∶N比和微生物量碳影响。因此,土壤容重、土壤全氮、土壤有机碳、C∶N比、微生物量碳、矿质氮差异可能是影响不同土地利用方式中微生物群落和功能变化的主要因素。 | 吴希慧 王蕊 高长青 高胜 杜兰兰 KHAN Asif BARMON Milon 郭胜利 | 2021 | 生态学报2021，41，20： | 10 |
| 13 | Effect of graphene nanoplatelets(GNPs)addition on strength and ductility of magnesium-titanium alloys显示文摘Effect of graphene nanoplatelets(GNPs)addition on mechanical properties of magnesium–10wt%Titanium(Mg–10Ti)alloy is investigated in current work.The Mg-(10Ti+0.18GNPs)composite was synthesized using the semi powder metallurgy method followed by hot extrusion.Microstructural characterization results revealed the uniform distribution of reinforcement(Ti+GNPs)particles in the matrix,therefore(Ti+GNPs)particles act as an effective reinforcing filler to prevent the deformation.Room temperature tensile results showed that the addition of Ti+GNPs to monolithic Mg lead to increase in 0.2%yield strength(0.2%YS),ultimate tensile strength(UTS),and failure strain.Scanning Electron Microscopy(SEM),Energy-Dispersive X-ray Spectroscopy(EDS)and X-Ray Diffraction(XRD)were used to investigate the surface morphology,elemental dispersion and phase analysis,respectively. | Muhammad Rashad Fusheng Pan Aitao Tang Yun Lu Muhammad Asif Shahid Hussain Jia She Jun Gou Jianjun Mao | 2013 | Journal of Magnesium and Alloys2013，1，3： | 10 |
| 14 | 术后意外胆囊癌显示文摘目的探讨术后意外胆囊癌的处理对策。方法对78例术后胆囊癌进行回顾性临床病理分析,并就临床分期和预后与非意外胆囊癌组进行比较。结果78例术后意外胆囊癌,术前诊断以各类急、慢性胆囊炎、胆囊结石和胆囊息肉为主。77例行单纯胆囊切除术,1例行胆囊造瘘术。按UICC标准进行TNM分期,0期9例,Ⅰ期27例,Ⅱ期31例,Ⅲ期11例,无ⅣA和ⅣB期病例;意外胆囊癌组的肿瘤分期与非意外组相比,差异有统计学意义(P<0.0001)。意外胆囊癌组的预后也明显好于非意外组(P<0.01)。结论手术医师应提高对胆囊癌的警惕性。术中常规剖视胆囊,对可疑病变行冰冻切片检查。对T2~T4期的术后意外胆囊癌应宜再次剖腹做根治性手术,以改善预后。 | 秦净 王炳生 韩天权 张柏和 沈铭昌 邓杰 Asif Rashid Ann W Hsing 高玉堂 | 2005 | 中华肝胆外科杂志2005，11，9： | 9 |
| 15 | High temperature formability of graphene nanoplatelets-AZ31 composites fabricated by stir-casting method显示文摘Outstanding mechanical properties of graphene nanoplatelets(GNPs)make them ideal reinforcement for mass production of composites.In this research,the composites were fabricated by stir-casting method.GNPs were added in 1.5 and 3.0 wt.%into Mg–3wt.%Al–1wt.%Zn(AZ31)magnesium alloy.As cast ingots were preheated for one hour and extruded at 350℃ with extrusion ratio of 5.2:1.As extruded AZ31-GNPs composites were micro-structurally characterized with X-ray diffraction,optical microscopy and scanning electron microscopy.Vickers microhardness of synthesized materials was investigated both in parallel and perpendicular to extrusion directions.Room temperature mechanical testing revealed that with increasing GNP’s content,tensile fracture strain was remarkably increased without significant compromise in tensile strength.Furthermore,as extruded AZ31-3GNPs composites were subjected to tensile testing at temperatures ranging from 75℃ to 300℃ with initial strain rate of 2×10^(−3)s^(−1) to evaluate high temperature formability of composite.It was found that like CNTs,GNPs also have the potential to sustain tensile strength at high temperatures. | Muhammad Rashad Fusheng Pan Yanglu Liu Xianhua Chen Han Lin Rongjian Pan Muhammad Asif Jia She | 2016 | Journal of Magnesium and Alloys2016，4，4： | 9 |
| 16 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 17 | PI3K signaling pathway targeting by using different molecular approaches to treat cancer显示文摘Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment. | Mohammad Rashid Shahid Karim Babar Ali Shamshir Khan Makhmur Ahmad Asif Husain Ravinesh Mishra | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，9： | 7 |
| 18 | 饮食与胆囊癌关系的流行病学研究显示文摘目的探讨饮食因素与胆囊癌发病的关联,为采取预防措施提供科学依据。方法采用全人群病例对照研究,研究对象为1997年6月-2001年5月期间确诊的、年龄在35-74岁的上海市区368例胆囊癌新发病例以及按性别、年龄(5岁一组)频数配对的895例人群对照。采用非条件logistic回归模型分析饮食各因素与胆囊癌的关系。结果女性中,与最低四分位数组相比,葱属类蔬菜年摄入次数最高四分位组的调整OR为0.55(95%CI:0.31-0.97;Ptrend=0.06);与不吃组比较,大蒜头和洋葱最高摄入组的调整OR分别为0.59(95%CI:0.34-0.99;Ptrend=0.03)和0.52(95%CI:0.30-0.91;Ptrend=0.01)。与最低四分位组比较,腌制品摄入其余各组调整OR在女性中依次为1.06、1.88、2.31,Ptrend<0.001;与不吃乳腐组比较,余三组的调整OR依次为1.19、1.47、1.88.Ptrend<0.01。男性结果与女性类似,腌制品和葱属类蔬菜摄入的各组OR都有不显著的升高和降低。结论新鲜蔬菜,尤其是葱属类蔬菜对胆囊癌的保护作用在女性比男性明显,而且以大蒜头、洋葱的保护作用较为显著。而腌制品摄入,尤其是乳腐,可能会增加胆囊癌的发病风险。 | 张学宏 高玉堂 邓杰 程家蓉 刘恩菊 邬恺 孙璐 Asif Rashid Gloria Gridley Ann W Hsing | 2005 | 肿瘤2005，25，4： | 7 |
| 19 | 腹腔镜胆囊切除术与意外胆囊癌显示文摘目的:探讨腹腔镜胆囊切除术后意外发现胆囊癌的处理方法。方法:对1997~2001年14例腹腔镜胆囊切除术中或术后意外发现的胆囊癌进行临床病理分析。结果:14例意外胆囊癌中男2例,女12例。平均年龄66.1岁。术前诊断1例为胆囊息肉,余13例为胆囊炎胆囊结石(92.8%)。有7例中转开腹手术,1例因发现转移仅在腹腔镜下行腹壁肿块活检术,6例完成腹腔镜胆囊切除术。术后病理TNM分期:0期1例,Ⅰ期4例,Ⅱ期3例,Ⅲ期3例,Ⅳb期3例。至随访截止时,已有9人死亡,5人仍存活,存活期超过36个月者有4人,最长者已存活68月。结论:腹腔镜胆囊切除术不适用于胆囊癌病人。提倡腹腔镜术中对可疑病灶进行冰冻切片病理检查。对胆囊癌侵犯深度超过肌层者应中转开腹或术后再次开腹行根治性手术。 | 秦净 王炳生 韩天权 张柏和 沈铭昌 邓杰 Asif Rashid Ann W Hsing 高玉堂 | 2005 | 外科理论与实践2005，10，4： | 6 |
| 20 | 基于OpenSees的火灾下钢结构连续性倒塌分析显示文摘主要研究了火灾下平面钢框架的连续性倒塌模式和机制。应用OpenSees软件,对某5跨8层平面钢框架结构模型进行数值分析,研究了荷载比、梁柱刚度比和火灾场景对结构倒塌模式的影响。结果表明,随着荷载比的增大,结构倒塌模式由侧向倾倒式倒塌变为整体下沉式倒塌;当梁柱刚度比较小时,由于梁的悬链性效应,使结构发生偏向受火开间的侧向位移直至倒塌(弱梁机制),当梁的刚度比较大时,破坏首先发生在框架底层柱,结构呈整体下沉式倒塌(强梁机制);火灾中水平和竖向分布易分别引起结构局部和整体的倒塌。 | 姜健 Asif Usmani 李国强 | 2015 | 防灾减灾工程学报2015，35，1： | 6 |
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