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| 1 | Terlipressin and hepatorenal syndrome: What is important for nephrologists and hepatologists显示文摘Hepatorenal syndrome (HRS) is a reversible form of functional renal failure that occurs with advanced hepatic cirrhosis and liver failure. Despite mounting research in HRS, its etiology and medical therapy has not been resolved. HRS encompasses 2 distinct types. Type 1 is characterized by the rapid development of renal failure that occurs within 2 wk and involves a doubling of initial serum creatinine. Type 2 has a more insidious onset and is often associated with ascites. Animal studies have shown that both forms, in particular type 1 HRS, are often precipitated by bacterial infections and cir-culatory changes. The prognosis for HRS remains very poor. Type 1 and 2 both have an expected survival time of 2 wk and 6 mo, respectively. Progression of liver cir-rhosis and the resultant portal hypertension leads to the pooling of blood in the splanchnic vascular bed. The ensuing hyperdynamic circulation causes an ineffective circulatory volume which subsequently activates neuro-hormonal systems. Primarily the sympathetic nervoussystem and the renin angiotensin system are activated, which, in the early stages of HRS, maintain adequate circulation. Both advanced cirrhosis and prolonged ac-tivation of neurohormonal mechanisms result in fatal complications. Locally produced nitric oxide may have the potential to induce a deleterious vasodilatory effect on the splanchnic circulation. Currently medical therapy is aimed at reducing splanchnic vasodilation to resolve the ineffective circulation and maintain good renal per-fusion pressure. Terlipressin, a vasopressin analogue, has shown potential benefit in the treatment of HRS. It prolongs both survival time and has the ability to re-verse HRS in the majority of patients. In this review we aim to focus on the pathogenesis of HRS and its treatment with terlipressin vs other drugs. | Ahmed A Magan Atif A Khalil Mohamed H Ahmed | 2010 | World Journal of Gastroenterology2010，16，41： | 11 |
| 2 | Surface plasmon polariton at the interface of dielectric and graphene medium using Kerr effect显示文摘We theoretically investigate the control of surface plasmon polariton(SPP) generated at the interface of dielectric and graphene medium under Kerr nonlinearity. The controlled Kerr nonlinear signal of probe light beam in a dielectric medium is used to generate SPPs at the interface of dielectric and graphene medium. The positive, negative absorption, and dispersion properties of SPPs are modified and controlled by the control and Kerr fields. A large amplification(negative absorption) is noted for SPPs under the Kerr nonlinearity. The normal/anomalous slope of dispersion and propagation length of SPPs is modified and controlled with Kerr nonlinearity. This leads to significant variation in slow and fast SPP propagation. The controlled slow and fast SPP propagation may predict significant applications in nano-photonics, optical tweezers, photovoltaic devices, plasmonster, and sensing technology. | Bakhtawar Muhammad Haneef B A Bacha H Khan M Atif | 2018 | Chinese Physics B2018，27，11： | 3 |
| 3 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 4 | Induction, production, repression, and de-repression of exoglucannase systhesis in Aspergillus niger 显示文摘 | Atif H Amber' Y Rojoka M I | 2004 | Bioresouree Technology2004，94，3： | 1 |
| 5 | Hermaphroditic,demas- culinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses显示文摘 | TYRONE B H ATIF C LEE M | 2002 | Proceeding of the National A- cademy of Sciences of the United States of America2002，99，8： | 1 |
| 6 | Induction, production, repression, and de-repression of exoglucannase systhesis in Aspergillus niger 显示文摘 | Atif H Amber Y Rojoka M I | 2004 | Bioresource Technology2004，94，3： | 1 |
| 7 | 3D brain tumor seg-mentation in MRI using fuzzy classification, symmetry analysis and spatially constrained deformable models 显示文摘 | Khotanlou H Colliot O Atif J | 2009 | Fuzzy Sets and Systems2009，160，10： | 1 |
| 8 | Protein proteinase inhibitor genes in combat against insects, pests, and pathogens:natural and engi- neered phytoproteetion显示文摘 | HAQ S K ATIF S M KHAN R H | 2004 | Archives of Biochemistry and Biophysics2004，431，1： | 1 |
| 9 | Protein proteinase inhibitor genes in combat against insects, pests, and pathogens: natural and engineered phytoprotection显示文摘 | HAQ S K ATIF S M KHAN R H | 2004 | Arch Biochem Biophys2004，431，： | 1 |
| 10 | Induction, production, repression, and de -repression of exoglucanase synthesis in Aspergil -lus niger显示文摘 | Atif H A Yasmeen MI | 2004 | Bioresouree Technology2004，94，3： | 1 |
| 11 | Biochemical characterization, stability studies and N-terminal sequence of a Bi-functional inhibitor from Phaseolus ureus Roxb (Mung bean) 显示文摘 | Haq S K Atif S M Khan R H | 2005 | Biochimie2005，87，12： | 1 |
| 12 | Effective Electricity Market Simulators显示文摘 | Atif D Charles H Wu Y C | 2001 | IEEE Computer Applications in Power2001，14，1： | 1 |
| 13 | Heat stress-induced alterations of antioxidants in the freshwater fish Channa punctata Bloch 显示文摘 | Kaur M Atif F Ali M Rehman H Raisuddin S | 2005 | Journal of Fish Biology2005，67，： | 1 |
| 14 | Biological characteristics and host stage preference of mealybug parasitoid Aenasius bambawalei Hayat (Hymenoptera:Encyrtidae)显示文摘 | Zainul-Abdin AM J Gogi MD Muhammad A Fiaz H Abbas SK Hoor S Atif M | | 0，，01： | 1 |
| 15 | Protein proteinase inhibitor genes in combat against insects, pests, and pathogens : natural and engineered phytoprotection 显示文摘 | HAQ S K ATIF S M KHAN R H | 2004 | Archives of Biochemistry and Biophysics2004，431，1： | 1 |
| 16 | Femtosecond light distribution at skin and liver of rats:analysis for use in optical diagnostics显示文摘 | ULLAH H ATIF M FIRDOUS S | 2010 | Laser Physics Letters2010，7，12： | 1 |
| 17 | Production and characterization of a highly active cellobiase from Aspergillus niger grown solid state fermentation 显示文摘 | Muhammad I R Muhammad W A Atif H | 2006 | World Journal of Microbiology and Biotechnology2006，22，9： | 1 |
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