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| 1 | Multidrug resistance associated proteins in multidrug resistance显示文摘Multidrug resistance proteins(MRPs) are members of the C family of a group of proteins named ATP-binding cassette(ABC) transporters.These ABC transporters together form the largest branch of proteins within the human body.The MRP family comprises of 13 members,of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the cell.They are mainly lipophilic anionic transporters and are reported to transport free or conjugates of glutathione(GSH),glucuronate,or sulphate.In addition,MRP1 to MRP3 can transport neutral organic drugs in free form in the presence of free GSH.Collectively,MRPs can transport drugs that differ structurally and mechanistically,including natural anticancer drugs,nucleoside analogs,antimetabolites,and tyrosine kinase inhibitors.Many of these MRPs transport physiologically important anions such as leukotriene C4,bilirubin glucuronide,and cyclic nucleotides.This review focuses mainly on the physiological functions,cellular resistance characteristics,and probable in vivo role of MRP1 to MRP9. | Kamlesh Sodani Atish Patel Rishil J.Kathawala | 2012 | Chinese Journal of Cancer2012，31，2： | 42 |
| 2 | Role of ABC transporters in cancer chemotherapy显示文摘Multidrug resistance(MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality.The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette(ABC) transporters,which can increase efflux of drugs from cancer cells,thereby decreasing intracellular drug concentration.Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs.This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR. | Sun, Yue-Li Patel, Atish Kumar, Priyank Chen, Zhe-Sheng | 2012 | Chinese Journal of Cancer2012，31，2： | 10 |
| 3 | PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR显示文摘Multidrug resistance protein 7(MRP7,ABCC10)is a recently identified member of the ATP-binding cassette(ABC)transporter family,which adequately confers resistance to a diverse group of antineoplastic agents,including taxanes,vinca alkaloids and nucleoside analogs among others.Clinical studies indicate an increased MRP7 expression in non-small cell lung carcinomas(NSCLC)compared to a normal healthy lung tissue.Recent studies revealed increased paclitaxel sensitivity in the Mrp7^(-/-)mouse model compared to their wild-type counterparts.This demonstrates that MRP7 is a key contributor in developing drug resistance.Recently our group reported that PD173074,a specific fibroblast growth factor receptor(FGFR)inhibitor,could significantly reverse P-glycoprotein-mediated MDR.However,whether PD173074 can interact with and inhibit other MRP members is unknown.In the present study,we investigated the ability of PD173074 to reverse MRP7-mediated MDR.We found that PD173074,at non-toxic concentration,could significantly increase the cellular sensitivity to MRP7 substrates.Mechanistic studies indicated that PD173074(1μmol/L)significantly increased the intracellular accumulation and in-turn decreased the efflux of paclitaxel by inhibiting the transport activity without altering expression levels of the MRP7 protein,thereby representing a promising therapeutic agent in the clinical treatment of chemoresistant cancer patients. | Nagaraju Anreddy Atish Patel Kamlesh Sodani Rishil J.Kathawala Eugenie P.Chen John N.D.Wurpel Zhe-Sheng Chen | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 2 |
| 4 | Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in drosophila 显示文摘 | Garrett GG Renny RM Atish G | 2008 | Plos One2008，3，6： | 1 |
| 5 | Neprilysin gene transfer reduces human amypoid pathology in transgenic mice显示文摘 | Robert A Marr Edward Rockenstein Atish Mukherjee | 2003 | J Neuroscience2003，23，6： | 1 |
| 6 | Distribution circuit state estimation using a probabilistic approach 显示文摘 | Atish K Ghosh David L Lubkeman | 1997 | IEEE Transactions on Power Systems1997，12，2： | 1 |
| 7 | The novel 3, 4-dihydropyrimidin-2(lH)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory antibacterial and antifungal activity evaluation显示文摘 | Rajesh H T Atish H R Girish D H | 2011 | Bioorganic & Medicinal Chemistry Letters2011，03，： | 1 |
| 8 | Lycopene protects againstmemory impairment and mito-oxidative damage induced bycolchicinein rats: An evidence of nitric oxide signaling显示文摘 | Atish Prakash Anil Kumar | 2013 | EuropeanJournalofPharmacology2013，721，5： | 1 |
| 9 | Sinha: Comprehending Object and Process Models: An Empirical Study显示文摘 | Prabuddha De and Atish P | 1999 | IEEE Transactions on Software Engineering1999，25，4： | 1 |
| 10 | Protective effect of curcumin (Curcuma longa) against d-galactose-induced senescence in mice显示文摘 | Anil Kumar Atish Prakash Samrita Dogra | 2011 | Journal of Asian Natural Products Research2011，，1： | 1 |
| 11 | Distribution circuit state estimation using a probabilistic approach 显示文摘 | Atish K G David L Lubkem | 1997 | IEEE Transactions on Power Systems1997，12，2： | 1 |
| 12 | Development and Integration of a Data Acquisition System for SST-1 Phase-1 Plasma Diagnostics显示文摘Long pulse(of the order of 1000 s or more) SST-1 tokamak experiments demand a data acquisition system that is capable of acquiring data from various diagnostics channels without losing useful data(and hence physics information) while avoiding unnecessary generation of a large volume data.SST-1 Phase-1 tokamak operation has been envisaged with data acquisition of several essential diagnostics channels.These channels demand data acquisition at a sampling rate ranging from 1 kilo samples per second(KSPS) to 1 mega samples per second(MSPS).Considering the technical characteristics and requirements of the diagnostics,a data acquisition system based on PXI and CAMAC has been developed for SST-1 plasma diagnostics.Both these data acquisition systems are scalable.Present data acquisition needs involving slow plasma diagnostics are catered by the PXI based data acquisition system.On the other hand,CAMAC data acquisition hardware meets all requirements of the SST-1 Phase-1 fast plasma diagnostics channels.A graphical user interface for both data acquisition systems(PXI and CAMAC) has been developed using LabVIEW application development software.The collected data on the local hard disk are directly streaming to the central server through a dedicated network for post-shot data analysis.This paper describes the development and integration of the data acquisition system for SST-1 Phase-1 plasma diagnostics.The integrated testing of the developed data acquisition system has been performed using SST-1 central control and diagnostics signal conditioning units.In the absence of plasma shots,the integrated testing of the data acquisition system for the initial diagnostics of SST-1 Phase-1 operation has been performed with simulated physical signals.The primary engineering objective of this integrated testing is to validate the performance of the developed data acquisition system under simulated conditions close to that of actual tokamak operation.The data acquisition is synchronized with a clock and trigger provided by the central timing system. | Amit K SRIVASTAVA Manika SHARMA Imran MANSURI Atish SHARMA Tushar RAVAL Subrata PRADHAN | 2012 | Plasma Science and Technology2012，14，11： | 1 |
| 13 | Revealing Progesterone’s Role in Uterine and Mammary Gland Biology: Insights from the Mouse显示文摘 | Rodrigo Fernandez-Valdivia Atish Mukherjee Biserka Mulac-Jericevic Orla Conneely Francesco DeMayo Paula Amato John Lydon | 2005 | Semin Reprod Med2005，，01： | 1 |
| 14 | International Capital Mobility amongst the Major Industrialized Countries: Too Little or Too Much? 显示文摘 | Ghosh Atish R | 1995 | Economic Journal1995，，105： | 1 |
| 15 | Distribution circuit state estimation using a probabilistic approach显示文摘 | Atish K Ghosh David L Lubkeman | 1997 | IEEE Transactions on Power Systems1997，12，2： | 1 |
| 16 | Load modeling for distribution circuit state estimation 显示文摘 | Atish K Ghosh David L Lubkeman | 1997 | IEEE Transactions on Power Delivery1997，12，2： | 1 |
| 17 | Toward developing data warehousing process standards:An ontology-based review of existing methodologies 显示文摘 | Arun Sen Atish P Sirtha | 2007 | IEEE Transactions on Systems2007，37，1： | 1 |
| 18 | Liquid chromatography–mass spectrometry-based quantification of steroidal glycoalkaloids from Solanum xanthocarpum and effect of different extraction methods on their content显示文摘 | Atish T. Paul Sanjay Vir K.K. Bhutani | 2008 | Journal of Chromatography A2008，，1： | 1 |
| 19 | International Capital Mobility amongst the Major Industrialized Countries:Too Little or Too Much显示文摘 | Ghosh Atish R | | 0，，105： | 1 |
| 20 | Arsenic trioxide and lead acetate induce apoptosis in adult rat hepatic stem cells 显示文摘 | Soumik A Sonali R Atish R | 2009 | Cell Biol Toxicol2009，25，： | 1 |
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