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| 1 | Risk factors for small bowel angioectasia:The impact of visceral fat accumulation显示文摘AIM: To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.METHODS: We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding(OGIB) from January 2009 to September 2013. The visceral fat area(VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records.Logistic regression analysis was used to evaluate associations.RESULTS: Capsule endoscopy revealed small bowel angioectasia in 18/198(9.1%) patients with OGIB.Compared to patients without small bowel angioectasia,those with small bowel angioectasia had a significantly higher VFA(96 ± 76.0 cm2 vs 63.4 ±51.5 cm2, P = 0.016) and a higher prevalence of liver cirrhosis(61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia(22% vs 9%,P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio(OR) for each 10-cm2 increment = 1.1; [95% confidence interval(CI):1.02-1.19; P = 0.021] and liver cirrhosis(OR = 6.1,95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.CONCLUSION: VFA is positively associated with theprevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB. | Atsuo Yamada Ryota Niikura Yuka Kobayashi Hirobumi Suzuki Shuntaro Yoshida Hirotsugu Watabe Yutaka Yamaji Yoshihiro Hirata Kazuhiko Koike | 2015 | World Journal of Gastroenterology2015，21，23： | 4 |
| 2 | Impact of fecal occult blood on obscure gastrointestinal bleeding:Observational study显示文摘AIM: To elucidate the association between small bowel diseases(SBDs) and positive fecal occult blood test(FOBT) in patients with obscure gastrointestinal bleeding(OGIB).METHODS: Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy(CE) and FOBT were enrolled(mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBDs was compared between patients with positive and negative FOBT.RESULTS: CE revealed SBDs in 72 patients(36%). FOBT was positive in 100 patients(50%) and negative in 102(50%). The prevalence of SBDs was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBDs was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBDs between positive and negative FOBT group(47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBDs in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evidentam on g patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBDs in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE(P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more days before CE(43% vs 25%, P = 0.20).CONCLUSION: The present study suggests that positive FOBT may be useful for predicting SBDs in patients with occult OGIB. Positive FOBT indicates higher likelihood of ulcers or tumors in patients with occult OGIB. Undergoing CE within a day after FOBT achieved a higher diagnostic yield for patients with occult OGIB. | Yuka Kobayashi Hirotsugu Watabe Atsuo Yamada Hirobumi Suzuki Yoshihiro Hirata Yutaka Yamaji Haruhiko Yoshida Kazuhiko Koike | 2015 | World Journal of Gastroenterology2015，21，1： | 2 |
| 3 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada Takafumi Sugimoto Shintaro Kondo Miki Ohta Hirotsugu Watabe Shin Maeda Goichi Togo Yutaka Yamaji Keiji Ogura Makoto Okamoto Haruhiko Yoshida Takao Kawabe Tateo Kawase Masao Omata | 2008 | Diseases of the Colon & Rectum2008，，1： | 2 |
| 4 | Utility of single and double balloon endoscopy in patients with difficult colonoscopy: A randomized controlled trial显示文摘AIM: To compare the utility of single-balloon colonoscopy (SBC) or double-balloon colonoscopy (DBC) for difficult colonoscopies. METHODS: Between August 2008 and June 2010, patients in whom total colonoscopy failed within 30 min of insertion were assigned randomly to undergo either SBC or DBC. No sedatives were used. After the endoscopy, all patients were asked to evaluate pain during the procedure on a 10-point analog scale (1 = no pain; 10 = worst imaginable pain) with a questionnaire. The study outcomes were the cecal intubation rate and time, endoscopic findings, complications, and pain score. RESULTS: The SBC and DBC groups included 11 and 10 patients, respectively. All but one SBC patient achieved total colonoscopy successfully. The cecal intubation times were 18 min (range: 10-85 min) and 12.8 min (range: 9.5-42 min) in the SBC and DBC groups, respectively (P= 0.17). No difference was observed in the prevalence of colon polyps between the SBC and DBC groups (45% vs 30%, P = 0.66). SBC showed advanced colon cancer in the ascending colon, which was inaccessible using conventional colonoscopy. The respective pain scores were 5 (1-10) [median (range)] and 5 (1-6) in the SBC and DBC groups (P = 0.64). No complications were noted in any patient. CONCLUSION: The utility of singleand double-balloon endoscopy for colonoscopy seems comparable in patients with incomplete colonoscopy using a conventional colonoscope. | Atsuo Yamada Hirotsugu Watabe Noriyuki Takano Goichi Togo Yutaka Yamaji Haruhiko Yoshida Takao Kawabe Masao Omata Kazuhiko Koike | 2013 | World Journal of Gastroenterology2013，19，29： | 1 |
| 5 | Single-balloon versus double-balloon endoscopy for achieving total enteroscopy: a randomized, controlled trial显示文摘 | Noriyuki Takano Atsuo Yamada Hirotsugu Watabe Goichi Togo Yutaka Yamaji Haruhiko Yoshida Takao Kawabe Masao Omata Kazuhiko Koike | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 6 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada M.D. Takafumi Sugimoto M.D. Shintaro Kondo M.D. Miki Ohta M.D. Hirotsugu Watabe M.D. Shin Maeda M.D. Goichi Togo M.D. Yutaka Yamaji M.D. Keiji Ogura M.D. Makoto Okamoto M.D. Haruhiko Yoshida M.D. Takao Kawabe M.D. Tateo Kawase M.D. Masao Omat | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 7 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada M.D. Takafumi Sugimoto M.D. Shintaro Kondo M.D. Miki Ohta M.D. Hirotsugu Watabe M.D. Shin Maeda M.D. Goichi Togo M.D. Yutaka Yamaji M.D. Keiji Ogura M.D. Makoto Okamoto M.D. Haruhiko Yoshida M.D. Takao Kawabe M.D. Tateo Kawase M.D. Masao Omat | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 8 | A New Isolation Method of Caseinoglycopeptide from Sweet Cheese Whey显示文摘 | Tadao Saito Atsuo Yamaji Takatoshi Itoh | 1991 | J Dairy Sci1991，74，9： | 1 |
| 9 | Association between colorectal polyps and hypertension treatment显示文摘 | Yoshitaka Watanabe Yutaka Yamaji Yuka Kobayashi Shuntaro Yoshida Takafumi Sugimoto Atsuo Yamada Hirotsugu Watabe Yoshihiro Hirata Kazuhiko Koike | 2015 | Journal of Digestive Diseases2015，，11： | 1 |
| 10 | Single-balloon versus double-balloon endoscopy for achieving total enteroscopy: a randomized, controlled trial显示文摘 | Noriyuki Takano Atsuo Yamada Hirotsugu Watabe Goichi Togo Yutaka Yamaji Haruhiko Yoshida Takao Kawabe Masao Omata Kazuhiko Koike | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 11 | Single-balloon versus double-balloon endoscopy for achieving total enteroscopy: a randomized, controlled trial显示文摘 | Noriyuki Takano Atsuo Yamada Hirotsugu Watabe Goichi Togo Yutaka Yamaji Haruhiko Yoshida Takao Kawabe Masao Omata Kazuhiko Koike | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 12 | A randomized controlled trial of sodium phosphate tablets and polyethylene glycol solution for polyp detection显示文摘 | Haruka KAMBE Yutaka YAMAJI Takafumi SUGIMOTO Atsuo YAMADA Hirotsugu WATABE Haruhiko YOSHIDA Masao OMATA Kazuhiko KOIKE | 2012 | Journal of Digestive Diseases2012，，7： | 1 |
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